Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) ...tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.
The change of customer behaviors and the fluctuation of spot prices can affect the benefits of electricity retailers. To address this issue, an incentive-based demand response (DR) model involving ...the utility and elasticity of customers is proposed for maximizing the benefits of retailers. The benefits will increase by triggering an incentive price to influence customer behaviors to change their demand consumptions. The optimal reduction of customers is obtained by their own profit optimization model with a certain incentive price. Then, the sensitivity of incentive price on retailers’ benefits is analyzed and the optimal incentive price is obtained according to the DR model. The case study verifies the effectiveness of the proposed model.
•Multi-stage NiO rod-on-sheet nanoarrays on Ni foam was fabricated by a facile hydrothermal treatment strategy.•This catalyst enables superior electrochemical sensing of glucose with lower ...determination limit and higher sensitivity.•This sensor demonstrates high selectivity and sensitivity as well as practicability in human serum for glucose sensing.
Hierarchical nanoarray is an appealing architecture for molecular recognition on account of its larger surface area and easier accessibility for target molecules compared with single-stage nanoarray and traditional nanoparticle. Herein, we demonstrate that surface-engineering of multi-stage nickel oxide rod-on-sheet nanoarrays on Ni foam (NiO NS@NR/Ni foam) exhibits ultra-high catalytic activity toward electro-oxidation of glucose. When used for nonenzymatic sensing of glucose, this NiO NS@NR/Ni foam electrode shows a wide response range of 0.75–3837μM, a low determination limit of 0.75μM, a high sensitivity of 2739.5μAmM−1cm−2, and a fast response time of less than 4s. This proposed sensor also demonstrates high selectivity, good long-term stability and practicability in real human serum samples for glucose detection.
In low-dimensional systems with strong electronic correlations, the application of an ultrashort laser pulse often yields novel phases that are otherwise inaccessible. The central challenge in ...understanding such phenomena is to determine how dimensionality and many-body correlations together govern the pathway of a non-adiabatic transition. To this end, we examine a layered compound, 1T-TiSe
, whose three-dimensional charge-density-wave (3D CDW) state also features exciton condensation due to strong electron-hole interactions. We find that photoexcitation suppresses the equilibrium 3D CDW while creating a nonequilibrium 2D CDW. Remarkably, the dimension reduction does not occur unless bound electron-hole pairs are broken. This relation suggests that excitonic correlations maintain the out-of-plane CDW coherence, settling a long-standing debate over their role in the CDW transition. Our findings demonstrate how optical manipulation of electronic interaction enables one to control the dimensionality of a broken-symmetry order, paving the way for realizing other emergent states in strongly correlated systems.
In January 2020, the subclade 2.3.4.4h of highly pathogenic avian influenza (H5N6) virus infected migratory whooper swans and mute swans in Xinjiang, western China. The virus is lethal to chickens ...and ducks but has low pathogenicity in mice. Antigenically, this subclade is similar to the H5N1 vaccine seed virus Re-11.
In high-temperature superconductivity, the process that leads to the formation of Cooper pairs, the fundamental charge carriers in any superconductor, remains mysterious. We used a femtosecond laser ...pump pulse to perturb superconducting Bi₂Sr₂CaCu₂08+δ and studied subsequent dynamics using time and angle-resolved photoemission and infrared reflectivity probes. Gap and quasiparticle population dynamics revealed marked dependencies on both excitation density and crystal momentum. Close to the d-wave nodes, the superconducting gap was sensitive to the pump intensity, and Cooper pairs recombined slowly. Far from the nodes, pumping affected the gap only weakly, and recombination processes were faster. These results demonstrate a new window into the dynamical processes that govern quasiparticle recombination and gap formation in cuprates.
A modified non‐linear magnetic equivalent circuit (MEC) model is presented for double‐stator single‐rotor axial flux permanent magnet (AFPM) (DSSR‐AFPM) machine considering stator radial‐end ...flux‐leakage, which is severer under a heavier load. Compared to the conventional MEC model for DSSR‐AFPM machine, the proposed model can predict the electromagnetic performance more accurately when the machine operates under a heavy load. The proposed MEC model is verified by the finite element analysis (FEA) on a 24‐slot/20‐pole DSSR‐AFPM machine. The comparison results show that the relative error between the proposed MEC model and FEA is <4% for back electromotive force and <5% for average electromagnetic torque, respectively. Specifically, the relative error of the average torque for the modified MEC model is 4.92% at 28.30 Arms/mm2 slot current density, which is lower than the conventional MEC model, that is, 7.75%.
A modified non‐linear magnetic equivalent circuit model is presented for double‐stator single‐rotor axial flux permanent magnet machine considering stator radial‐end flux‐leakage, which is severer under a heavier load. The relative error between the proposed magnetic equivalent circuit model and finite element analysis is <4% for back electromotive force and <5% for average electromagnetic torque, respectively.
Rescue work after a coal mine accident is fraught with challenges and dangers. Considering the safety of rescue workers and the urgency of a rescue mission, it is necessary to use coal mine rescue ...robots to perform the tasks of environmental detection and rescue. As a key part of the robot sensing system, a visual sensor can provide much information about a scene. Among vision sensor types, binocular vision has the advantages of being noncontact and passive, and it is the key technology for a robot to acquire obstacle information and reconstruct a three-dimensional scene. Therefore, coal mine rescue robots based on binocular vision have become a popular research topic in the field of mine safety. First, the research status of camera calibration and stereo vision matching for binocular vision is systematically introduced in this paper. Second, the latest research progress on coal mine rescue robots based on binocular vision is reviewed from the perspective of technological applications and development. Finally, the technical challenges and future development trends of binocular vision in coal mine rescue robots are described.
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•Angiogenesis impairment caused by GBHs is related to mitochondrial dysfunction.•GBHs have negative impact on placental function.•Maternal GBHs exposure during pregnancy impairs ...postnatal progeny health.•Betaine protects placenta and postnatal progeny against GBHs-induced damage.•The limit level of glyphosate residue by governments needs to be reappraised.
Glyphosate-based herbicides (GBHs) are the most widely used pesticide worldwide and can provoke placental injury. However, whether and how GBHs damage angiogenesis in the placenta is not yet known. This work evaluated the safety of glyphosate on pregnant sows based on the limit level by governments and investigated the effects and mechanism of Low-GBHs (20 mg/kg) and High-GBHs (100 mg/kg) exposure on placental angiogenesis. Results showed that gestational exposure to GBHs decreased placental vessel density and cell multiplication by interfering with the expression of VEGFA, PLGF, VEGFr2 and Hand2 (indicators of angiogenesis), which may be in relation to oxidative stress-induced disorders of mitochondrial fission and fusion as well as the impaired function of the mitochondrial respiratory chain. Additionally, GBHs destroyed barrier function and nutrient transport in the placenta, and was accompanied by jejunum oxidative stress in newborn piglets. However, GBHs exposure had no significant differences on sow reproductive performance. As a natural antioxidant, betaine treatment protected placenta and newborn piglets against GBHs-induced damage. In conclusion, GBHs impaired placental angiogenesis and function and further damaged the health of postnatal progeny, these effects may be linked to mitochondrial dysfunction. Betaine treatment following glyphosate exposure provided modest relief.
The WUSCHEL-related homeobox (WOX) gene family plays a crucial role in regulating embryonic development, organ formation, and stress resistance. Yellowhorn (Xanthoceras sorbifolia Bunge), a ...drought-resistant tree known for its oil production, lacks sufficient information regarding the WOX gene family. To understand the evolutionary mechanisms and potential functions of this gene family in yellowhorn, we conducted a comprehensive investigation on its expression patterns and evolutionary characteristics. Our analysis revealed the presence of nine XsWOX genes in the yellowhorn genome, which could be categorized into three distinct clades through a phylogenetic analysis. A chromosomal localization analysis indicated that these nine XsWOX genes were situated on six out of the fifteen chromosomes. An intra-species collinear analysis revealed only one pair of tandem duplicated genes within the XsWOX family. The promoter regions of the XsWOX family were found to contain responsive cis-acting elements associated with plant growth and development, stress responses, and hormone signaling. Moreover, an analysis of the gene expression profiles in different developmental stages of callus revealed significant expressions of XsWOX1, XsWOX4, and XsWOX5 in embryogenic callus and somatic embryo formation, suggesting that they have special roles in regulating yellowhorn’s somatic embryogenesis. Furthermore, the expression level of XsWOX5 indicated its potential involvement not only in organ formation but also in responding to low temperature, salt, and saline-alkali stresses. Overall, our findings lay a solid foundation for future in-depth studies on the functionality and evolution of XsWOX genes in yellowhorn.
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