•Abnormal facet joint parameters are significantly associated with LDH.•Young adults with higher FT should be paid more attention, to prevent the occurrence of LDH.•At the L4–L5 level, intervertebral ...disk herniation tended to occur ipsilateral to the side with a lower facet joint angle when FT was present.
We aimed to determine whether there is an association, in young adults, between the occurrence of lumbar disk herniation (LDH) at a given segment and the segment’s facet joint parameters facet orientation (FO) and tropism (FT). In addition, associations between facet joint parameters in the corresponding segment and LDH laterality were also investigated.
We retrospectively analyzed data from 529 patients who were between 18 and 35 years old, who had experienced single-level LDH (L4–5 or L5–S1) between June 2017 and December 2019, and with<2 years of clinical history. We included an additional 122 patients with no history of LDH as an age-matched control group. LDH were classified by laterality (left-sided, right-sided, or central herniation). At each level, we investigated the relationship between facet joint parameters and herniation laterality.
FOA values at the L4–L5 level and the L5–S1 level were significantly lower and FT was higher for the LDH group compared with those for the control group. The level at which LDH occurred, FOL, FOR, and FT differed significantly among the three groups. There was a significant association between herniationlaterality and FO at the L4–L5 level but not at the L5–S1 level.
Abnormal facet joint parameters are significantly associated with LDH. Young adults with higher FT should be paid more attention, to prevent the occurrence of LDH. Compared with L5–S1 level, intervertebral disk herniation at the L4–L5 level tended to occur ipsilateral to the side with a lower facet joint angle when FT was present.
While the state-of-the-art network embedding approaches often learn high-quality embeddings for high-degree nodes with abundant structural connectivity, the quality of the embeddings for low-degree ...or tail nodes is often suboptimal due to their limited structural connectivity. While many real-world networks are long-tailed, to date little effort has been devoted to tail node embeddings. In this article, we formulate the goal of learning tail node embeddings as a few-shot regression problem, given the few links on each tail node. In particular, since each node resides in its own local context, we personalize the regression model for each tail node. To reduce overfitting in the personalization, we propose a locality-aware meta-learning framework, called meta-tail2vec , which learns to learn the regression model for the tail nodes at different localities. Moreover, to address the heterogeneity in nodes and edges on heterogeneous information networks (HINs), we further extend the proposed model and formulate meta-tail2vec+ , which is based on a dual-adaptation mechanism to facilitate the locality-aware tail node embeddings on HINs. Finally, we conduct extensive experiments and demonstrate the promising results of both meta-tail2vec and its extension meta-tail2vec+.
Colon cancer is the most common malignant tumor of the gastrointestinal tract, and approximately 80%–90% of colon cancers are colon adenocarcinomas (COADs). This study aimed to screen key microRNAs ...(miRNAs) associated with COAD. Differentially expressed (DE) miRNAs were screened between COAD and adjacent cancer samples based on the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas obtained from datasets. The miRNAs of interest were validated using quantitative real-time polymerase chain reaction. Moreover, the effects of hsa-miR-135b-5p on the biological behavior of COAD cells were observed. To obtain the target genes of hsa-miR-135b-5p, transcriptome sequencing of the SW480 cells was performed, followed by protein-protein interaction (PPI) network and hsa-miR-135b-5p-target gene regulatory network construction and prognostic analysis. Downregulation of hsa-miR-135b-5p significantly inhibited SW480 cell proliferation, migration, and invasion and significantly facilitated apoptosis (P < 0.05). A total of 3384 DEmRNAs were screened, and enrichment analysis showed that the upregulated mRNAs were enriched in 25 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and 326 Gene Ontology Biological Processes (GO-BPs) while the downregulated mRNAs were enriched in 20 KEGG pathways and 276 GO-BPs. A PPI network was then constructed, and H2BC14, H2BC3, and H4C11 had a higher degree. In addition, a total of 352 hsa-miR-135b-5p-gene regulatory relationships were identified. Prognostic analysis showed that FOXN2, NSA2, MYCBP, DIRAS2, DESI1, and RAB33B had prognostic significance (P < 0.05). In addition, the validation analysis results showed that FOXN2, NSA2, and DESI1 were significantly expressed between the miR-135b-5p-inhibitor and negative control groups (P < 0.05). Therefore, downregulation of hsa-miR-135b-5p inhibits cell proliferation, migration, and invasion in COAD, and carcinogenesis may function by targeting FOXN2, NSA2, MYCBP, DIRAS2, DESI1, and RAB33B.
As a crucial link in debris flow disaster control, control engineering can be divided into geotechnical engineering and ecological engineering. Geotechnical engineering is less affected by climate ...and can play an immediate role in the treatment of debris flow in a short time. Ecological engineering has obvious regulating effect on surface runoff and erosion. Furthermore, there are few discussions on comprehensive treatment effect between geotechnical engineering and ecological engineering for debris flow. Therefore, taking the debris flow gullies with control engineering implemented in Wenchuan area of Sichuan Province as the research object, this paper puts forward an evaluation method of treatment effect comprehensively considering the geotechnical engineering and ecological engineering. It is mainly based on the impact of engineering on the formation conditions of debris flow and the damage of projects. The comprehensive treatment effect of geotechnical and ecological engineering for debris flow is analyzed. The corresponding evaluation indexes are extracted, including 5 first-class evaluation indexes such as landform factor and water source factor, as well as 11 s-class evaluation indexes such as the peak flow reduction rate, the sediment retention ratio and the LAI ratio. The Fuzzy-AHP method is used to establish the evaluation model of treatment effect. The evaluation results are graded. It is considered that the treatment effect of other debris flow gullies is medium or above except that two gullies are poor. The evaluation results are consistent with the actual investigation, which provides a reference for the control of debris flow in this area.
The aim of this study was to summarize oncological and functional results and to investigate surgical treatment methods and efficacies by conducting a retrospective study of patients with fibrous ...dysplasia (FD) in the proximal femur. A total of 15 patients with FD in the proximal femur were selected. Among them, 12 cases were monostotic and 3 cases were polyostotic. In addition, 2 cases were accompanied by shepherd's crook deformity. All cases received internal fixation following focus curettage and impaction grafting. Among them, valgus osteotomy was conducted for 2 cases of shepherd's crook deformity. All patients were followed up for 12-32 months. For 2 patients with shepherd's crook deformity in the proximal femur, the collodiaphysial angle was recovered after an orthopedic procedure following osteotomy. In addition, no patient presented with postoperative recurrent lesions. At 3 months following surgery, local bone resorption was visible in the bone grafting area. Between 8 and 12 months after surgery, the bones in the bone grafting area had healed, pain had disappeared and gaits were nearly normal. An effective internal fixation following thorough focus curettage and allograft bone transplantation is an effective method of treating FD in the proximal femur. For patients with shepherd's crook deformity, it is also necessary to perform valgus osteotomy to recover hip joint function.
•There has been a strong climate transition change from warm-dry to warm-wet.•Drought still was limiting factor for radial growth of two dominant conifer trees.•Siberian larch had divergent response ...with first increase and then decrease trend.•Schrenk spruce had stable responses showing continuously decreasing growth trend.•Water management should be adjusted according to trees response characteristics.
As global climate warming intensified in the latter half of the 20th century, the radial growth of trees exhibited unstable climate responses and growth trends, thereby reducing the accuracy of growth-climate ecological relationship and the scientificity of forest management based on tree rings. We assessed the temporal stability of radial growth responses and determined the growth patterns of two dominant co-occurring conifer tree species, Siberian larch (Larix sibirica) and Schrenk spruce (Picea schrenkiana), in the Tianshan Mountains of northwest China under a climate that shifted from warm-dry to warm-wet. The primary conclusions were as follows: (1) drought in the growing season was the main limiting factor of radial growth of the two tree species in recent decades through the analysis of the dynamic relationships between tree radial growth and climate factors; (2) Siberian larch had divergent responses to mean temperature in summer of the previous year, while Schrenk spruce had relatively stable responses to the mean temperature, total precipitation and monthly standardized precipitation-evapotranspiration index (SPEI) in spring of the current year by comparing the response variations before and after the abrupt increases in temperature and the moving correlation function; and (3) Siberian larch showed first increasing and then decreasing trends, while Schrenk spruce showed continuously decreasing trends based on calculating the basal area increment (BAI). The study results confirmed that forests in arid and semiarid environments would be subjected to more serious drought impacts, resulting in radial growth decline, tree mortality and community degradation with climate warming in the future. Therefore, it is important to adopt effective management measures for different species according to their response characteristics to climate change.
In current study, curcumin-loaded bioactive nanocomplexes (Cur NCs) (2 %, 5 %, 8 %, and 11 %) were used to prepare corn starch (CS)-based composite films (CS-Cur NCs). Fourier-transform infrared ...spectroscopy, X-ray diffraction and scanning electron microscopy revealed that Cur NCs were uniformly dispersed in the polymer matrix via physical interaction. Moreover, the mechanical, gas barrier, hydrophobicity, optical, and thermal properties and the antioxidant activity of composite films were potentially improved with the addition of Cur NCs. Subsequently, CS-based film with 11 % Cur NCs exhibited high antioxidant activity (the scavenging rates of DPPH and ABTS are 50.07 % ± 0.82 % and 65.26 % ± 1.60 %, respectively) and was used for packaging blueberries. Compared with the control, the CS-Cur NCs packaging treatment effectively improved the appearance and nutrition of blueberries, and maintained the high activity of several antioxidant enzymes. Furthermore, CS-Cur NCs packaging treatment significantly improved the ascorbic acid (AsA) and glutathione (GSH) levels, thus regulating the AsA-GSH cycle system and suppressing the accumulation of reactive oxygen species (ROS). In summary, the CS-Cur NCs packaging could effectively conserve the postharvest quality of blueberries by improving antioxidant enzyme activity and suppressing excessive accumulation of ROS, which contributes to the development of bioactive packaging and provides novel insights into the preservation of blueberries. This work demonstrates that the development of active packaging is promising to absorb the oxidative radicals from food, and protect the food from inherent and external factors, thus enhancing the quality, security, and shelf-life of the food during storage.
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•Starch-based film embedded with curcumin-loaded nanocomplexes was prepared.•Physical property, antioxidant activity of starch-based films was improved.•Bioactive film packaging improved the postharvest quality of blueberry.•Bioactive film packaging alleviated the accumulation of ROS in blueberry.•Antioxidant enzyme activities, AsA-GSH cycle of blueberry were regulated.
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•Sulfonated and ordered mesoporous silica superacids (OMS-SO3H-xs) were developed.•The OMS-SO3H-xs were designed from an enhanced solvent-free assembly route.•OMS-SO3H-xs have high ...density of acid sites with superacidity and enhanced accessibility.•OMS-SO3H-xs show superior performance for NH3 selective adsorption and separation..•OMS-SO3H-xs show extremely high-precision on selective elimination of ppm level of NH3.
NH3 reversible adsorption and separation show great significance during its production and utilization, traditional adsorbents show either complex synthetic procedures or unsatisfied separation precision. We report here a class of sulfonic group functionalized and ordered mesoporous silica superacids (OMS-SO3H-xs) via enhanced host–guest assembly between copolymer templates and silica precursors without additional solvent. The OMS-SO3H-xs have large surface areas (463.7–910.5 m2/g), abundant micropores tandem well-ordered mesopores, high concentration of –SO3H (2.5 mmol/g) with extremely-high acid strength. Consequently, the OMS-SO3H-xs exhibit ultra-high precision for NH3 reversible adsorption and separation, giving high NH3 capacity (9.0 & 7.6 mmol/g at 25 & 50 °C and 1.0 bar) with extraordinary NH3/N2 (0.1/0.9) Ideal Adsorption Solution Theory (IAST) selectivities (1200 & 2235). The room temperature saturated breakthrough NH3 capacities of OMS-SO3H-xs were up to 3.38 mmol/g (3.0v%NH3/24.75v%N2/72.25v%H2), which can be well-maintained after 8th cycling without attenuation. The above features found in the OMS-SO3H-xs were resulted from their high density of –SO3H superacid sites those were homogeneously anchored into the ordered mesoporosity, which not only enhances their interaction with NH3, but also achieves the controllable NH3 interaction and transportation inside the mesochannels.
A biocatalytic system comprising fungal laccase and mediators can generate phenol radicals and efficiently eliminate various triarylmethane dyes. This study systematically explores the kinetic impact ...of dissolved organic matter (DOM), represented by humic substance (HS consisting of 90% fulvic acid, from lignite), on the decolorization of seven typical triarylmethane dyes by Trametes versicolor laccase and twenty natural mediators. Among these, 4-hydroxybenzyl alcohol (4-HA) and methyl violet (MV) undergo in-depth investigation regarding degradation products, pathways, and reaction mechanisms. In instances where HS hampers laccase-alone decolorization, such as malachite green, Coomassie brilliant blue, bromophenol blue, and acid magenta, this inhibition may persist despite mediator introduction. Conversely, in cases where HS facilitates decolorization, such as crystalline violet and ethyl violet, most laccase-mediator systems (LMSs) can still benefit. For MV decolorization by laccase and 4-HA, HS's kinetic effect is controlled by concentration and reaction time. A 5 mg/L HS increased the decolorization rate from 50% to 67% within the first hour, whereas 10 mg/L HS only achieved 45%. After 16 h of reaction, HS's impact on decolorization rate diminishes. Furthermore, the addition of HS enhances precipitation production, probably due to its involvement in polymerization with MV and mediator. Computational simulations and spectral monitoring reveal that low HS concentrations accelerate laccase-mediated demethylation by disrupting the chromophores bound to MV, thus promoting the decolorization of MV. Conversely, inhibition by high HS concentrations stems from the competitive binding of the enzyme pocket to the mediator, and the reduction of phenol free radicals in the system. Molecular docking and kinetic simulations revealed that laccase forms complexes with both the mediator and MV. Interestingly, the decolorization of MV occurred through a non-radical mechanism in the presence of HS. This work provided a reference for screening of high catalytic performance mediators to remove triarylmethane dyes in the actual water environment.
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•Dissolved HS had a trade-off effect on laccase-mediator (LMS) biocatalysis system.•The impact on dye removal by HS depends on its concentration and reaction time.•Competitive inhibition and radical quenching by HS lead to reduced removal rate.•Dye decolorization occurred through non-radical mechanism with HS around.
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