A rectangular filtering dielectric resonator antenna (FDRA) with low profile, wide bandwidth, and high gain is first investigated in this communication. It is fed by a microstrip-coupled slot from ...bottom, with open stub of the microstrip feedline elaborately designed to provide two radiation nulls at band edges for a filtering function. A separation is introduced in the slot to provide a good suppression level in lower stopband, while two parasitic strips are parallelly added to the microstrip feedline to offer good suppression in the upper stopband, and consequently, a compact FDRA with a quasi-elliptic bandpass response is obtained without involving specific filtering circuits. Based on the design, a modified DRA fed by a pair of separated slots is proposed to further enhance the gain by ~4 dB. A prototype operating at 5 GHz has been fabricated and measured for demonstration. The reflection coefficient, the radiation pattern, and the antenna gain are studied, and reasonable agreement between the measured and simulated results is observed. The prototype has a 10-dB impedance bandwidth of 20.3%, an average gain of 9.05 dBi within passband, and an out-of-band suppression level of more than 25 dB within a wide stopband.
A bstract Using e + e − collision datasets corresponding to a total integrated luminosity of 21.7 fb − 1 collected with the BESIII detector at the BEPCII collider at center-of-mass energies ranging ...from 4.009 GeV to 4.951 GeV, the energy-dependent cross sections of $$ {e}^{+}{e}^{-}\to p{K}^{-}\overline{\Lambda}+c.c. $$ e + e − → p K − Λ ¯ + c . c . are measured for the first time. By fitting these energy-dependent cross sections, we search for the excited ψ states ψ (4160) and ψ (4415), and the vector charmonium-like states ψ (4230), ψ (4360), and ψ (4660). No evidence for these is observed and the upper limits on the branching fractions of these states decaying into $$ p{K}^{-}\overline{\Lambda}+c.c. $$ p K − Λ ¯ + c . c . are set at the 90% confidence level.
Statistical analysis of air mass back trajectories combined with long-term ambient air pollution measurements are useful tools for source identification. Using these methods, the geographic ...information system (GIS) based software, TrajStat, was developed to view, query, and cluster the trajectories and compute the potential source contribution function (PSCF) and concentration weighted trajectory (CWT) analyses when measurement data are included.
The glycolysis of poly(ethylene terephthalate) (PET) was studied using several ionic liquids and basic ionic liquids as catalysts. The basic ionic liquid, 1-butyl-3-methylimidazolium hydroxyl ...(BmimOH), exhibits higher catalytic activity for the glycolysis of PET, compared with 1-butyl-3-methylimidazolium bicarbonate (BmimHCO3), 1-butyl-3-methylimidazolium chloride (BmimCl) and 1-butyl-3-methylimidazolium bromide (BmimBr). FT-IR, 1H NMR and DSC were used to confirm the main product of glycolysis was bis(2-hydroxyethyl) terephthalate (BHET) monomer. The influences of experimental parameters, such as the amount of catalyst, glycolysis time, reaction temperature, and dosages of ethylene glycol on the conversion of PET, yield of BHET were investigated. The results showed a strong influence of the mixture evolution of temperature and reaction time on depolymerization of PET. Under the optimum conditions of m(PET):m(EG): 1:10, dosage of BmimOH at 0.1g (5wt%), reaction temperature 190°C and time 2h, the conversion of PET and the yield of BHET were 100% and 71.2% respectively. Balance between the polymerization of BHET and depolymerization of PET could be changed when the reaction time was more than 2h and contents of catalyst and EG were changed.
Using a sample of 106 million ψ(3686) decays, ψ(3686) → γχcJ (J = 0, 1, 2) and ψ (3686) → γχcJ, χcJ → γJ/ψ (J = 1, 2) events are utilized to study inclusive χcJ → anything, χcJ → hadrons , and J/ψ → ...anything distributions, including distributions of the number of charged tracks, electromagnetic calorimeter showers, and π0s, and to compare them with distributions obtained from the BESIII Monte Carlo simulation. Information from each Monte Carlo simulated decay event is used to construct matrices connecting the detected distributions to the input predetection "produced" distributions. Assuming these matrices also apply to data, they are used to predict the analogous produced distributions of the decay events. Using these, the charged particle multiplicities are compared with results from MARK I. Further, comparison of the distributions of the number of photons in data with those in Monte Carlo simulation indicates that G-parity conservation should be taken into consideration in the simulation.
Inositol polyphosphate 4-phosphatase type II (INPP4B) negatively regulates phosphatidylinositol 3-kinase signaling and is a tumor suppressor in some types of cancers. However, we have found that it ...is frequently upregulated in human colon cancer cells. Here we show that silencing of INPP4B blocks activation of Akt and serum- and glucocorticoid-regulated kinase 3 (SGK3), inhibits colon cancer cell proliferation and retards colon cancer xenograft growth. Conversely, overexpression of INPP4B increases proliferation and triggers anchorage-independent growth of normal colon epithelial cells. Moreover, we demonstrate that the effect of INPP4B on Akt and SGK3 is associated with inactivation of phosphate and tensin homolog through its protein phosphatase activity and that the increase in INPP4B is due to Ets-1-mediated transcriptional upregulation in colon cancer cells. Collectively, these results suggest that INPP4B may function as an oncogenic driver in colon cancer, with potential implications for targeting INPP4B as a novel approach to treat this disease.
This meta-analytic review aimed to examine the pooled prevalence rates of Internet addiction and gaming disorders in Southeast Asia. Several databases including PubMed, MEDLINE, PsycINFO, Web of ...Science, Embase, and Cochrane Central were searched and a total of 24 studies were included in this study. The selection of studies was conducted in accordance to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Two meta-analyses were conducted to examine data on Internet addiction and gaming disorders separately. A random-effects model was employed to derive the pooled prevalence rate. Mixed-effects meta-regression and subgroup analyses were performed to examine the moderators of the between-study heterogeneity. Publication bias was tested using the Egger's regression test and funnel plot. Only seven out of the 11 Southeast Asian countries were represented in the literature. All except for two of the included studies were cross-sectional in nature. The findings revealed a pooled prevalence rate of 20.0% (95% confidence interval: 14.5%-27.0%) and 10.1% (95% confidence interval: 7.3%-13.8%) for Internet addiction and gaming disorders respectively. Mean age and study population were significant moderators of the between-study heterogeneity in the prevalence rates of gaming disorders such that samples involving older participants showed higher prevalence rate than those involving younger individuals. Country of study was found to be significant moderator of the between-heterogeneity for both Internet addiction and gaming disorders, however the findings should be interpreted with caution due to the small and unbalanced sample sizes. There was no significant publication bias. Such epidemiology research should be extended to the Southeast Asian countries that have not been studied or are under-studied. Given that the prevalence rates appear to be higher in Southeast Asia than in other world regions, future research should also explore the factors behind these inter-regional differences. Further longitudinal studies should also be conducted to examine the trajectories of such disorders.
The amplified in breast cancer 1 (AIB1) gene has been considered to play an oncogenic role in human cancers, but its clinical/prognostic significance in non-small-cell lung cancer (NSCLC) is still ...unclear.
The methods of immunohistochemistry and FISH were utilized to examine protein expression and amplification of AIB1 in 230 informative surgically resected NSCLCs and in 30 samples of normal lung tissues.
Overexpression and amplification of AIB1 were found in 48.3% and 8.2% of NSCLCs, respectively. AIB1 overexpression was associated with AIB1 gene amplification and cell proliferation but not related to estrogen receptor (ER)-α, ER-β, progesterone receptor or androgen receptor status. A positive correlation between AIB1 overexpression and an ascending pathologic node stage in lung adenocarcinoma (ADC) was observed (P = 0.043). Univariate survival analysis demonstrated a significant association of AIB1 overexpression with shortened patient survival, especially for those with stage III disease (P < 0.001). Importantly, AIB1 expression was evaluated as the most significant predictor for survival in multivariate analysis (hazards ratio = 2.069, P < 0.001).
Overexpression of AIB1 might provide a selective advantage for lymph node metastasis of lung ADC and serve as a useful biomarker for poor prognosis for NSCLC patients.
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•Cu–Ti intermetallics was systematically investigated by first principles.•CuTi phase presents the best stability, highest hardness but a higher brittleness.•Cu–Ti intermetallics is a ...mixture of covalent, ionic and metallic nature.•CuTi particles dispersed on a ductile Cu4Ti3 matrix should be designed for surface coating.
To design a high-performance Cu–Ti intermetallic coating, first-principles calculation is conducted to systematically investigate the phase stability, mechanical and electronic properties of the Cu–Ti binary intermetallics. The phase stability and mechanical properties are studied by calculating the formation enthalpy and independent elastic constants, respectively. The calculated formation enthalpy indicates that β-Cu4Ti, CuTi and CuTi2 are stable phases at 0K, while α-Cu4Ti, Cu3Ti, Cu3Ti2, and Cu4Ti3 are metastable phases. In addition, the mechanical properties of Cu–Ti intermetallics present a positive correlation with their formation enthalpy. The electronic structures of the Cu–Ti intermetallics are evaluated by analyzing the bonds character to reveal the bonding characteristics, which is crucial to the phase stability and mechanical properties. Among the Cu–Ti intermetallics studied, CuTi phase exhibits the highest stability, hardness and a higher brittleness among all Cu–Ti intermetallics, while other Cu–Ti intermetallics show good toughness. Based on the calculated results, a high strength Cu–Ti intermetallic coating consisting of hard CuTi particles on a ductile Cu4Ti3 matrix is proposed.
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