High-energy cosmic-ray electrons and positrons (CREs), which lose energy quickly during their propagation, provide a probe of Galactic high-energy processes and may enable the observation of ...phenomena such as dark-matter particle annihilation or decay. The CRE spectrum has been measured directly up to approximately 2 teraelectronvolts in previous balloon- or space-borne experiments, and indirectly up to approximately 5 teraelectronvolts using ground-based Cherenkov γ-ray telescope arrays. Evidence for a spectral break in the teraelectronvolt energy range has been provided by indirect measurements, although the results were qualified by sizeable systematic uncertainties. Here we report a direct measurement of CREs in the energy range 25 gigaelectronvolts to 4.6 teraelectronvolts by the Dark Matter Particle Explorer (DAMPE) with unprecedentedly high energy resolution and low background. The largest part of the spectrum can be well fitted by a 'smoothly broken power-law' model rather than a single power-law model. The direct detection of a spectral break at about 0.9 teraelectronvolts confirms the evidence found by previous indirect measurements, clarifies the behaviour of the CRE spectrum at energies above 1 teraelectronvolt and sheds light on the physical origin of the sub-teraelectronvolt CREs.
Based on in situ and ground‐based observations, a new type of “polar cap hot patch” has been identified that is different from the classical polar cap enhanced density structure (cold patches). ...Comparing with the classical polar cap patches, which are transported from the dayside sunlit region with dense and cold plasma, the polar cap hot patches are associated with particle precipitations (therefore field‐aligned currents), ion upflows, and flow shears. The hot patches may have the same order of density enhancement as classical patches in the topside ionosphere, suggesting that the hot patches may be produced by transported photoionization plasma into flow channels. Within the flow channels, the hot patches have low‐energy particle precipitation and/or ion upflows associated with field‐aligned currents and flow shears. Corresponding Global Navigation Satellite System (GNSS) signal scintillation measurements indicate that hot patches may produce slightly stronger radio signal scintillation in the polar cap region than classical patches. A new type of polar cap patches, “polar cap hot patches,” is identified to differentiate enhanced density structures from classical patches. Hot patches are associated with particle precipitations, ion upflows, field‐aligned currents, and shear flows in the polar cap. Hot patches may lead to slightly stronger ionospheric scintillations of GNSS signals in the polar cap region than classical patches.
Key Points
A new type of polar cap patches, “polar cap hot patches,” is identified to differentiate enhanced density structures from classical patches
Hot patches are associated with particle precipitations, ion upflows, field‐aligned currents, and shear flows in the polar cap
Hot patches may lead to slightly stronger ionospheric scintillations of GNSS signals in the polar cap region than classical patches
ABSTRACT
MicroRNAs (miRNAs) play a crucial role in the growth, development, morphogenesis, signal transduction, and stress response in plants. The ICE (Inducer of CBF expression)‐CBF (C‐repeat ...binding factor)‐COR (Cold‐regulated gene) regulatory cascade is an important signalling pathway in plant response to low temperature stress, and it remains unknown whether this pathway is regulated by miRNAs.
In this study, high‐throughput sequencing was employed for predicting and identifying the miRNAs that were likely to target the ICE‐CBF‐COR pathway in Eucalyptus camaldulensis. A novel ICE1‐targeting miRNA, eca‐novel‐miR‐259‐5p (nov‐miR259), was further analysed.
A total of 392 conserved miRNAs and 97 novel miRNAs were predicted, including 80 differentially expressed miRNAs. Of these, 30 miRNAs were predicted to be associated with the ICE‐CBF‐COR pathway. The full‐length of mature nov‐miR259 was 22 bp and its precursor gene was 60 bp in length, with a typical hairpin structure. The RNA ligase‐mediated 5′ amplification of cDNA ends (5′‐RLM‐RACE) and Agrobacterium‐mediated tobacco transient expression assays demonstrated that nov‐miR259 could cleave EcaICE1 in vivo. Moreover, qRT‐PCR and Pearson's correlation analysis further revealed that the expression levels of nov‐miR259 were almost significantly negatively correlated with those of its target gene, EcaICE1, and the other genes in the ICE‐CBF‐COR pathway.
We first identified the nov‐miR259 as a novel ICE1‐targeting miRNA, and the nov‐miR259‐ICE1 module may be involved in regulating the cold stress response in E. camaldulensis.
We identified a novel miRNA nov‐miR259 in Eucalyptus sp. that could cleave ICE1 and respond to cold stress via the CBF signalling pathway.
Abstract
We present the second release of value-added catalogues of the LAMOST Spectroscopic Survey of the Galactic Anticentre (LSS-GAC DR2). The catalogues present values of radial velocity Vr, ...atmospheric parameters – effective temperature Teff, surface gravity log g, metallicity Fe/H, α-element to iron (metal) abundance ratio α/Fe (α/M), elemental abundances C/H and N/H and absolute magnitudes MV and $M_{K_{\rm s}}$ deduced from 1.8 million spectra of 1.4 million unique stars targeted by the LSS-GAC since 2011 September until 2014 June. The catalogues also give values of interstellar reddening, distance and orbital parameters determined with a variety of techniques, as well as proper motions and multiband photometry from the far-UV to the mid-IR collected from the literature and various surveys. Accuracies of radial velocities reach 5 km s−1 for the late-type stars, and those of distance estimates range between 10 and 30 per cent, depending on the spectral signal-to-noise ratios. Precisions of Fe/H, C/H and N/H estimates reach 0.1 dex, and those of α/Fe and α/M reach 0.05 dex. The large number of stars, the contiguous sky coverage, the simple yet non-trivial target selection function and the robust estimates of stellar radial velocities and atmospheric parameters, distances and elemental abundances make the catalogues a valuable data set to study the structure and evolution of the Galaxy, especially the solar-neighbourhood and the outer disc.
With the aim of gathering temporal trends on bacterial epidemiology and resistance from multiple laboratories in China, the CHINET surveillance system was organized in 2005. Antimicrobial ...susceptibility testing was carried out according to a unified protocol using the Kirby-Bauer method or automated systems. Results were analyzed according to Clinical and Laboratory Standards Institute (CLSI) 2014 definitions. Between 2005 and 2014, the number of bacterial isolates ranged between 22 774 and 84 572 annually. Rates of extended-spectrum β-lactamase production among Escherichia coli isolates were stable, between 51.7 and 55.8%. Resistance of E. coli and Klebsiella pneumoniae to amikacin, ciprofloxacin, piperacillin/tazobactam and cefoperazone/sulbactam decreased with time. Carbapenem resistance among K. pneumoniae isolates increased from 2.4 to 13.4%. Resistance of Pseudomonas aeruginosa strains against all of antimicrobial agents tested including imipenem and meropenem decreased with time. On the contrary, resistance of Acinetobacter baumannii strains to carbapenems increased from 31 to 66.7%. A marked decrease of methicillin resistance from 69% in 2005 to 44.6% in 2014 was observed for Staphylococcus aureus. Carbapenem resistance rates in K. pneumoniae and A. baumannii in China are high. Our results indicate the importance of bacterial surveillance studies.
A comparison tool has been developed by mapping the global GPS total electron content (TEC) and large coverage of ionospheric scintillations together on the geomagnetic latitude/magnetic local time ...coordinates. Using this tool, a comparison between large‐scale ionospheric irregularities and scintillations is pursued during a geomagnetic storm. Irregularities, such as storm enhanced density, middle‐latitude trough, and polar cap patches, are clearly identified from the TEC maps. At the edges of these irregularities, clear scintillations appeared but their behaviors were different. Phase scintillations (σφ) were almost always larger than amplitude scintillations (S4) at the edges of these irregularities, associated with bursty flows or flow reversals with large density gradients. An unexpected scintillation feature appeared inside the modeled auroral oval where S4 were much larger than σφ, most likely caused by particle precipitations around the exiting polar cap patches.
Key Points
A comparison tool has been developed by mapping global GPS TEC and large coverage of scintillations together on MLAT/MLT coordinates
σφ were larger than S4 at the edges of the irregularities associated with bursty flows or flow reversals with large density gradients
S4 were much larger than σφ in the auroral oval, most likely caused by particle precipitations around the exiting polar cap patches
The measurement of the energy spectrum of cosmic ray helium nuclei from 70 GeV to 80 TeV using 4.5 years of data recorded by the Dark Matter Particle Explorer (DAMPE) is reported in this work. A ...hardening of the spectrum is observed at an energy of about 1.3 TeV, similar to previous observations. In addition, a spectral softening at about 34 TeV is revealed for the first time with large statistics and well controlled systematic uncertainties, with an overall significance of 4.3σ. The DAMPE spectral measurements of both cosmic protons and helium nuclei suggest a particle charge dependent softening energy, although with current uncertainties a dependence on the number of nucleons cannot be ruled out.
To explore the characteristics of Helicobacter pylori resistance in China and the association between antibiotic resistance and several clinical factors.
H. pylori strains were collected from ...patients in 13 provinces or cities in China between 2010 and 2016. Demographic data including type of disease, geographic area, age, gender and isolation year were collected to analyse their association with antibiotic resistance. Antibiotic resistance was detected using the Etest test and the Kirby-Bauer disc diffusion method.
H. pylori were successfully cultured from 1117 patients. The prevalence of metronidazole, clarithromycin (CLA), azithromycin, levofloxacin (LEV), moxifloxacin, amoxicillin (AMO), tetracycline and rifampicin resistance was 78.2, 22.1, 23.3, 19.2, 17.2, 3.4, 1.9 and 1.5%, respectively. No resistance to furazolidone was observed. The resistance rates to LEV and moxifloxacin were higher in strains isolated from patients with gastritis compared to those with duodenal ulcer and among women. Compared to patients ≥40 years old, younger patients exhibited lower resistance rates to CLA, azithromycin, LEV and moxifloxacin. The resistance rates to CLA and AMO were higher in strains isolated more recently, and we also found that the prevalence of resistance to metronidazole, CLA, azithromycin and AMO were significantly different among different regions of China.
The resistance rates to metronidazole, CLA and LEV were high in China. Patient age, gender, disease and location were associated with the resistance of H. pylori to some antibiotics. Furazolidone, AMO and tetracycline are better choices for H. pylori treatment in China.
First experimental proof of a clear and strong dependence of the standard phase scintillation index (σφ) derived using Global Positioning System measurements on the ionospheric plasma flow around the ...noon sector of polar ionosphere is presented. σφ shows a strong linear dependence on the plasma drift speed measured by the Super Dual Auroral Radar Network radars, whereas the amplitude scintillation index (S4) does not. This observed dependence can be explained as a consequence of Fresnel frequency dependence of the relative drift and the used constant cutoff frequency (0.1 Hz) to detrend the data for obtaining standard σφ. The lack of dependence of S4 on the drift speed possibly eliminates the plasma instability mechanism(s) involved as a cause of the dependence. These observations further confirm that the standard phase scintillation index is much more sensitive to plasma flow; therefore, utmost care must be taken when identifying phase scintillation (diffractive phase variations) from refractive (deterministic) phase variations, especially in the polar region where the ionospheric plasma drift is much larger than in equatorial and midlatitude regions.
Key Points
A clear strong linear dependence of phase scintillation index on the plasma drift speed around noon sector of the polar ionosphere is presented
Observed dependence can be very possibly explained by the dependence of the shifted Fresnel frequency from the relative drift
Amplifies the importance of using dynamic cutoff frequency in detrending the phase of GPS signal in the polar region
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