Metal halide perovskites and derivatives exhibit a high sensitivity and low detection limit as direct X‐ray detectors. Inorganic 2D bismuth halide perovskites are promising for X‐ray detections, but ...have not been reported. Moreover, the quantitative relationship between the structural dimensionality of A3B2X9 perovskites and their compositions has never been investigated, and the underlying mechanism is unclear. Here, the key structural descriptors for 2D A3B2X9 perovskite derivatives are reported: i) octahedral factor μ, 0.377 < μ < 0895; ii) tolerance factor t, 0.8 < t < 1.06; iii) (rA‐0.55)/t < 1.48 Å. Accordingly, a new 2D A3B2X9 perovskite derivative, Rb3Bi2I9, with high X‐ray attenuation coefficients is found. The assembled X‐ray detector exhibits a high μτ product of 2.51 × 10−3 cm2 V−1, good sensitivity for 159.7 μC Gyair−1 cm−2, and a record low detection limit of 8.32 nGyair s−1 among all direct and indirect perovskite X‐ray detectors. The device also exhibits good stability toward external bias and continuous gamma ray radiations (480 000 Gy). This work provides crystal structural insights to rationally design 2D perovskites for new types of radiation detectors.
The key structural descriptors are reported for 2D A3B2X9 perovskite derivatives. By following the above designing rules, Rb3Bi2I9 is assembled into an X‐ray detector, exhibiting a low detection limit of 8.32 nGyair s−1 and suppressed ions migration. The inorganic composition also guarantees excellent stability toward continuous radiation from the 60Co source.
Long non-coding RNAs (lncRNAs) are tumor-associated biological molecules and have been found to be implicated in the progression of colorectal cancer (CRC). This study aims to examine the effects of ...lncRNA RP11-468E2.5 and its target genes (STAT5 and STAT6) on the biological activities of CRC cells via the Janus kinase-signal transducer and activator of transcription (JAK/STAT) signaling pathway.
We initially screened the GEO database for differentially expressed lncRNAs related to CRC and then made a prediction of the implicated target genes. Then we collected CRC tissues and adjacent normal tissues from 169 CRC patients. Human CRC HCT116 and SW480 cells were treated with small interference RNA (siRNA) against RP11-468E2.5, AG490 (an inhibitor of the JAK/STAT signaling pathway), or both in combination. Next, we measured the effects of RP11-468E2.5 treatment on cellular activities such as cell viability, cycle distribution and cell apoptosis, and studied interactions among RP11-468E2.5, STAT5/STAT6, and the JAK/STAT signaling pathway. Finally, an in vivo tumor formation assay was performed to observe the effect of RP11-468E2.5 on tumor growth.
The CRC-related gene microarray data showed low expression of RP11-468E2.5 in CRC surgical specimens. However, RP11-468E2.5 was confirmed to target STAT5 and STAT6, which participate in the JAK/STAT signaling pathway. CRC tissues showed lower expression of RP11-468E2.5, higher expression of STAT5, STAT6 and of the cell cycle marker Cyclin D1 (CCND1), compared to the findings in adjacent normal tissues. The treatment of siRNA against RP11-468E2.5 increased expression of JAK2, STAT3, STAT5, STAT6, CCND1 and Bcl-2 along with the extent of STAT3, STAT5 and STAT6 phosphorylation, while lowering expression of P21 and P27. Treatment with AG490 exhibited approximately opposite effects, whereas siRNA against RP11-468E2.5 treatment stimulated CRC cell proliferation and reduced cell apoptosis, while promoting cell cycle entry; AG490 treatment reversed these results.
Altogether, we conclude that up-regulation of RP11-468E2.5 inhibits the JAK/STAT signaling pathway by targeting STAT5 and STAT6, thereby suppressing cell proliferation and promoting cell apoptosis in CRC.
Non-intubated anesthesia (NIA) has been proposed for video-assisted thoracoscopic surgery (VATS), although how the benefit-to-risk of NIA compares to that of intubated general anesthesia (IGA) for ...certain types of patients remains unclear. Therefore, the aim of the present meta-analysis was to understand whether NIA or IGA may be more beneficial for patients undergoing VATS.
A systematic search of Cochrane Library, Pubmed and Embase databases from 1968 to April 2019 was performed using predefined criteria. Studies comparing the effects of NIA or IGA for adult VATS patients were considered. The primary outcome measure was hospital stay. Pooled data were meta-analyzed using a random-effects model to determine the standard mean difference (SMD) with 95% confidence intervals (CI).
Twenty-eight studies with 2929 patients were included. The median age of participants was 56.8 years (range 21.9-76.4) and 1802 (61.5%) were male. Compared to IGA, NIA was associated with shorter hospital stay (SMD -0.57 days, 95%CI -0.78 to -0.36), lower estimated cost for hospitalization (SMD -2.83 US, 95% CI -4.33 to -1.34), shorter chest tube duration (SMD -0.32 days, 95% CI -0.47 to -0.17), and shorter postoperative fasting time (SMD, -2.76 days; 95% CI -2.98 to -2.54). NIA patients showed higher levels of total lymphocytes and natural killer cells and higher T helper/T suppressor cell ratio, but lower levels of interleukin (IL)-6, IL-8 and C-reactive protein (CRP). Moreover, NIA patients showed lower levels of fibrinogen, cortisol, procalcitonin and epinephrine.
NIA enhances the recovery from VATS through attenuation of stress and inflammatory responses and stimulation of cellular immune function.
Using Jansky Very Large Array data obtained from high-resolution observations at 5.5 GHz at multiple epochs in 2014 and 2019, we have detected a population of radio variables and transients in the ...radio-bright zone at the Galactic center. With observations covering a sky area of 180 arcmin2 at an angular resolution of 0 4, we report new detections of 110 Galactic center compact radio (GCCR) sources with a size of <1″. The flux densities of GCCR sources exceed 70 Jy, with at least 10 significance. Among these sources, 82 are variable or transient and 28 are nonvariable. About 10% of them are expected to be extragalactic background sources. We discuss the possible astrophysical nature of the detected sources. As compared to the Galactic disk (GD) population of normal pulsars (NPs) and millisecond pulsars (MSPs), a majority (80%) of the GCCR sources appear to fall within the high flux density tail of the pulsar distribution, as extrapolated from a sample of NPs in the GD. However, MSPs extrapolated from the GD population are too weak to have contributed significantly to the GCCR population that has been detected. We also cross-correlated the GCCR sources with X-ray sources in Chandra X-ray catalogs and found that 42 GCCR sources have candidate X-ray counterparts. Most of the GCCR sources having X-ray counterparts are likely to be associated with unresolved or slightly resolved radio jets launched from X-ray binaries with a compact object, either a black hole or a neutron star.
Accumulating evidence links colorectal cancer (CRC) with the intestinal microbiota. However, the disturbance of intestinal microbiota and the role of Fusobacterium nucleatum during the colorectal ...adenoma-carcinoma sequence have not yet been evaluated.
454 FLX pyrosequencing was used to evaluate the disturbance of intestinal microbiota during the adenoma-carcinoma sequence pathway of CRC. Intestinal microbiota and mucosa tumor-immune cytokines were detected in mice after introducing 1,2-dimethylhydrazine (DMH), F. nucleatum or Berberine (BBR), using pyrosequencing and Bio-Plex Pro™ cytokine assays, respectively. Protein expressions were detected by western blotting.
The levels of opportunistic pathogens, such as Fusobacterium, Streptococcus and Enterococcus spp. gradually increased during the colorectal adenoma-carcinoma sequence in human fecal and mucosal samples. F. nucleatum treatment significantly altered lumen microbial structures, with increased Tenericutes and Verrucomicrobia (opportunistic pathogens) (P < 0.05 = in wild-type C57BL/6 and mice with DMH treatment). BBR intervention reversed the F. nucleatum-mediated increase in opportunistic pathogens, and the secretion of IL-21/22/31, CD40L and the expression of p-STAT3, p-STAT5 and p-ERK1/2 in mice, compared with mice fed with F. nucleatum alone.
F. nucleatum colonization in the intestine may prompt colorectal tumorigenesis. BBR could rescue F. nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment and blocking the activation of tumorigenesis-related pathways.
Blastocystis is a common protist that can infect domestic and wild animals worldwide. Yak (Bos grunniens), an ancient species which can survive in alpine regions, has supplied necessities to local ...residents in plateau areas for generations. However, the infections with Blastocystis in yaks has been ignored for a long time. In the present study, the infections and genotypes of Blastocystis spp. in domestic yaks from Qinghai Province (northwestern China) were explored.
Of 1027 faecal samples collected from yaks in seven regions of Qinghai Province, northwestern China, the total prevalence of Blastocystis was 27.07% (278/1027) targeting the small subunit ribosome rRNA (SSU rRNA) gene. This protist was detected in yaks within each examined age group, geographical origin and season. Significant difference in prevalence was found in yaks from different geographical origins. The highest prevalence (48.94%) was observed in animals from Haixi county. Sequence analysis revealed three animal-specific subtypes (ST10, ST12 and ST14) of Blastocystis spp. in these yaks, with ST10 being the predominant subtype widely distributed in all investigated regions, seasons and age groups. Interestingly, this is the first report about subtype ST12 infecting yaks.
To our knowledge, this is the first systematic report on Blastocystis prevalence in yaks from China, and the findings provide fundamental data for establishing effective control measures for this protist in yaks as well as other animals in China.
1 Introduction Major and profound changes have taken place in China over the past 30 years. An epidemic of cardiovascular diseases （CVD） in China is emerging as a result of lifestyle changes, ...urbanization, and the accelerated process of aging. The incidence of CVD is continuously increasing and will remain an upward trend in the next decade. Since 2005,
Solar-driven water splitting to produce hydrogen may be an ideal solution for global energy and environment issues. Among the various photocatalytic systems, platinum has been widely used to ...co-catalyse the reduction of protons in water for hydrogen evolution. However, the undesirable hydrogen oxidation reaction can also be readily catalysed by metallic platinum, which limits the solar energy conversion efficiency in artificial photosynthesis. Here we report that the unidirectional suppression of hydrogen oxidation in photocatalytic water splitting can be fulfilled by controlling the valence state of platinum; this platinum-based cocatalyst in a higher oxidation state can act as an efficient hydrogen evolution site while suppressing the undesirable hydrogen back-oxidation. The findings in this work may pave the way for developing other high-efficientcy platinum-based catalysts for photocatalysis, photoelectrochemistry, fuel cells and water-gas shift reactions.
We present observations of CO(3-2) and 13CO(3-2) emission near the supernebula in the dwarf galaxy NGC 5253, which contains one of the best examples of a potential globular cluster in formation. The ...0 3 resolution images reveal an unusual molecular cloud, "Cloud D1," that is coincident with the radio-infrared supernebula. The ∼6 pc diameter cloud has a linewidth, Δ v = 21.7 , that reflects only the gravitational potential of the star cluster residing within it. The corresponding virial mass is 2.5 × 105 . The cluster appears to have a top-heavy initial mass function, with M* 1-2 . Cloud D1 is optically thin in CO(3-2), probably because the gas is hot. Molecular gas mass is very uncertain but constitutes <35% of the dynamical mass within the cloud boundaries. In spite of the presence of an estimated ∼1500-2000 O stars within the small cloud, the CO appears relatively undisturbed. We propose that Cloud D1 consists of molecular clumps or cores, possibly star-forming, orbiting with more evolved stars in the core of the giant cluster.
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