Alterations of brain functional connectivity in patients with type 2 diabetes mellitus (T2DM) have been reported by resting-state functional magnetic resonance imaging studies, but the underlying ...precise neuropathological mechanism remains unclear. This study is aimed at investigating the implicit alterations of functional connections in T2DM by integrating functional connectivity strength (FCS) and Granger causality analysis (GCA) and further exploring their associations with clinical characteristics. Sixty T2DM patients and thirty-three sex-, age-, and education-matched healthy controls (HC) were recruited. Global FCS analysis of resting-state functional magnetic resonance imaging was performed to explore seed regions with significant differences between the two groups; then, GCA was applied to detect directional effective connectivity (EC) between the seeds and other brain regions. Correlations of EC with clinical variables were further explored in T2DM patients. Compared with HC, T2DM patients showed lower FCS in the bilateral fusiform gyrus, right superior frontal gyrus (SFG), and right postcentral gyrus, but higher FCS in the right supplementary motor area (SMA). Moreover, altered directional EC was found between the left fusiform gyrus and bilateral lingual gyrus and right medial frontal gyrus (MFG), as well as between the right SFG and bilateral frontal regions. In addition, triglyceride, insulin, and plasma glucose levels were correlated with the abnormal EC of the left fusiform, while disease duration and cognitive function were associated with the abnormal EC of the right SFG in T2DM patients. These results suggest that T2DM patients show aberrant brain function connectivity strength and effective connectivity which is associated with the diabetes-related metabolic characteristics, disease duration, and cognitive function, providing further insights into the complex neural basis of diabetes.
Measurement device-independent quantum key distribution (MDI-QKD) protocols are immune to all possible attacks on the photon detectors during quantum communication, but their key generation rates are ...low compared with those of other QKD schemes. Increasing each individual photon’s channel capacity is an efficient way to increase the key generation rate, and high-dimensional (HD) encoding is a powerful tool for increasing the channel capacity of photons. In this paper, we propose an HD MDI-QKD protocol with qudits hyper-encoded in spatial mode and polarization degrees of freedom (DOFs). In the proposed protocol, keys can be generated using the spatial mode and polarization DOFs simultaneously. The proposed protocol is unconditionally secure, even for weak coherent pulses with decoy states. The proposed MDI-QKD protocol may be useful for future quantum secure communication applications.
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Security in communication is vital in modern life. At present, security is realized by an encryption process in cryptography. It is unbelievable if a secure communication is ...achievable without encryption. In quantum cryptography, there is a unique form of quantum communication, quantum secure direct communication, where secret information is transmitted directly over a quantum channel. Quantum secure direct communication is drastically distinct from our conventional concept of secure communication, because it does not require key distribution, key storage and ciphertext transmission, and eliminates the encryption procedure completely. Hence it avoids in principle all the security loopholes associated with key and ciphertext in traditional secure communications. For practical implementation, defects always exist in real devices and it may downgrade the security. Among the various device imperfections, those with the measurement devices are the most prominent and serious ones. Here we report a measurement-device-independent quantum secure direct communication protocol using Einstein-Podolsky-Rosen pairs. This protocol eradicates the security vulnerabilities associated with the measurement device, and greatly enhances the practical security of quantum secure direct communication. In addition to the security advantage, this protocol has an extended communication distance, and a high communication capacity.
We report a single-electrode-based sliding-mode triboelectric nanogenerator (TENG) that not only can harvest mechanical energy but also is a self-powered displacement vector sensor system for ...touching pad technology. By utilizing the relative sliding between an electrodeless polytetrafluoroethylene (PTFE) patch with surface-etched nanoparticles and an Al electrode that is grounded, the fabricated TENG can produce an open-circuit voltage up to 1100 V, a short-circuit current density of 6 mA/m2, and a maximum power density of 350 mW/m2 on a load of 100 MΩ, which can be used to instantaneously drive 100 green-light-emitting diodes (LEDs). The working mechanism of the TENG is based on the charge transfer between the Al electrode and the ground by modulating the relative sliding distance between the tribo-charged PTFE patch and the Al plate. Grating of linear rows on the Al electrode enables the detection of the sliding speed of the PTFE patch along one direction. Moreover, we demonstrated that 16 Al electrode channels arranged along four directions were used to monitor the displacement (the direction and the location) of the PTFE patch at the center, where the output voltage signals in the 16 channels were recorded in real-time to form a mapping figure. The advantage of this design is that it only requires the bottom Al electrode to be grounded and the top PTFE patch needs no electrical contact, which is beneficial for energy harvesting in automobile rotation mode and touch pad applications.
The Miocene Lincang leaf assemblage is used in this paper as proxy data to reconstruct the palaeoclimate of southwestern Yunnan (SW China) and the evolution of monsoon intensity. Three quantitative ...methods were chosen for this reconstruction, i.e. Leaf Margin Analysis (LMA), Climate Leaf Analysis Multivariate Program (CLAMP), and the Coexistence Approach (CA). These methods, however, yield inconsistent results, particularly for the precipitation, as also shown in European and other East Asian Cenozoic floras. The wide range of the reconstructed climatic parameters includes the Mean Annual Temperature (MAT) of 18.5–24.7
°C and the Mean Annual Precipitation (MAP) of 1213–3711
mm. Compared with the modern Lincang climate (MAT, 17.3
°C; MAP, 1178.7
mm), the Miocene climate is slightly warmer, wetter and has a higher temperature seasonality. A detailed comparison on the palaeoclimatic variables with the coeval Late Miocene Xiaolongtan flora from the eastern part of Yunnan allows us to investigate the development and interactions of both South Asian and East Asian monsoons during the Late Miocene in southwest China, now under strong influence of these monsoon systems. Our results suggest that the monsoon climate has already been established in southwest Yunnan during the Late Miocene. Furthermore, our results support that both Southeast Asian and East Asian monsoons co-occurred in Yunnan during the Late Miocene.
Self‐powered nanosensors and nanosystems have attracted significant attention in the past decades and have gradually become the most desirable and promising prototype for environmental ...protection/detection because no battery is needed to power the device. Therefore, in this paper a design is proposed for a self‐powered photodetector based on triboelectric nanogenerator (TENG) configuration. 3D dendritic TiO2 nanostructures are synthesized as the built‐in UV photodetector as well as the contact material of the TENG. The cost‐effective, robust, and easily fabricated TENG‐based photodetector presents superior photoresponse characteristics, which include an excellent responsivity over 280 A W−1, rapid rise time (18 ms) and decay time (31 ms), and a wide detection range of light intensity from 20 μW cm−2 to 7 mW cm−2. In the last part of the paper, a stand‐alone and self‐powered environmental sensing device is developed by applying poly(methyl methacrylate) (PMMA) substrates and springs to assemble the TENG‐based photodetector. These results indicate that the new prototype sensing device based on the TENG configuration shows great potential as a self‐powered photodetector.
A fully integrated and active UV photodetector based on a triboelectric nanogenerator configuration is successfully demonstrated. Dendritic TiO2 nanostructures are designed as a built‐in photodetector and contact material of the triboelectric nanogenerator. With the advantages of easy fabrication, low cost, rapid response time, and excellent responsivity, this self‐powered active UV photodetector presents a new approach for building functional devices.
The sodium-glucose transporter 2 (SGLT2) inhibitors Canagliflozin and Dapagliflozin are recently approved medications for type 2 diabetes. Recent studies indicate the potential ability of SGLT2 ...inhibitors to attenuate cancer growth of SGLT2-expressing cancer cells, but there is little known about the effects of SGLT2 inhibitors on breast cancer. The goal in this research was to assess the anticancer activity of SGLT2 inhibitors in breast cancerin vitro and in vivo.
We test the SGLT2 expression in breast cancer using immunohistochemistry and immunoblot assay. MTT cytotoxicity assay, colony formation assay and human breast cancer cells nude mice xenograft model were performed to detect the effects of SGLT2 inhibitors on cancer cell proliferation and growth. Flow Cytometry assay was performed to determine if the SGLT2 inhibitors induced cell cycle arrest and apoptosis.
We proved that SGLT2 expresses in breast cancer cell lines and human breast tumor tissue samples. SGLT2 inhibitors Dapagliflozin and Canagliflozin exhibited a potent anti-proliferative effect in breast cancer cells as demonstrated by MTT, clonogenic survival assay in vitro and xenograft growth model in vivo. Furthermore, we found that SGLT2 inhibitors arrested cell cycle in G1/G0 phase and induced cell apoptosis. Western blot analysis demonstrated that treatment with SGLT2 inhibitors increased the phosphorylation of Amp-activated protein kinase (AMPK) and decreased the phosphorylation of 70 kDa ribosomal protein S6 kinase 1 (p70S6K1) in breast cancer cells.
These findings indicate that SGLT2 inhibitor-therapy induced AMPK-mediated cell cycle arrest and apoptosis, which is a potential novel strategy for the treatment of breast cancer.
Entanglement purification plays a fundamental role in long-distance quantum communication. In the paper, we put forward the first polarization entanglement purification protocol (EPP) for one type of ...nonlocal logic-qubit entanglement, i.e., concatenated Greenberger–Horne–Zeilinger (C-GHZ) state, resorting to the photon–atom interaction in low-quality (Q) cavity. In contrast to existing EPPs, this protocol can purify the bit-flip error and phase-flip error in both physic and logic level. Instead of measuring the photons directly, this protocol only requires to measure the atom states to judge whether the protocol is successful. In this way, the purified logic entangled states can be preserved for further application. Moreover, it makes this EPP repeatable so as to obtain a higher fidelity of logic entangled states. As the logic-qubit entanglement utilizes the quantum error correction (QEC) codes, which has an inherent stability against noise and decoherence, this EPP combined with the QEC codes may provide a double protection for the entanglement from the channel noise and may have potential applications in long-distance quantum communication.
•This protocol is the first polarization entanglement purification protocol for concatenated Greenberger–Horne–Zeilinger state in optical system with low-quality cavity.•This protocol can purify the bit-flip and phase-flip error in both physic and logic level.•The purified entangled state can be remained for future application and the protocol can also be repeated to obtain a higher fidelity.
Autotrophic iron-dependent denitrification (AIDD) is arising as a promising process for nitrogen removal from wastewater with a low carbon to nitrogen ratio. However, there is still a debate about ...the existence of such a process in activated sludge systems. This work provides evidence and elucidated the feasibility of autotrophic Fe(II)-oxidizing nitrate-reducing culture for nitrogen removal by long-term reactor operation, batch experimental verification, unstructured kinetic modeling and microbial community analyses. A relatively stable nitrate removal rate was achieved coupled with the oxidation of ferrous ions in 3-month operation of reactor. The kinetic modeling suggests that the iron oxidation was a growth-associated process in AIDD. Utilization of extracellular polymeric substances (and/or soluble microbial products) as electron donor for denitrification by heterotrophic denitrifiers was not mainly responsible for nitrogen removal in the reactor. After long-term operation of the reactor with activated sludge as inoculum, the enrichment culture KS-like consortium, dominated by Fe(II) oxidizer, Gallionellaceae, was successfully acclimated for autotrophic Fe(II)-oxidizing nitrate reduction. This work extents our understanding about the existence of such an autotrophic Fe(II)-oxidizing nitrate-reducing culture in both natural and engineered systems, and opens a door for its potential application in wastewater treatment.
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•Exclusive iron-dependent denitrification seeded with activated sludge was confirmed.•An average NRR of 0.33 kg-N m−3d−1 and FeOR of 6.46 kg-Fe m−3d−1 were achieved.•Batch tests and kinetic modeling validated autotrophic Fe-oxidizing nitrate reduction.•The enrichment consortium was dominated by Gallionellaceae.
Heterogeneous peroxymonosulfate (PMS)-based advanced oxidation processes (AOPs) have shown a great potential for pollutant degradation, but their feasibility for large-scale water treatment ...application has not been demonstrated. Herein, we develop a facile coprecipitation method for the scalable production (∼10 kg) of the Cu-Fe-Mn spinel oxide (CuFeMnO). Such a catalyst has rich oxygen vacancies and symmetry-breaking sites, which endorse it with a superior PMS-catalytic capacity. We find that the working reactive species and their contributions are highly dependent on the properties of target organic pollutants. For the organics with electron-donating group (e.g., -OH), high-valent metal species are mainly responsible for the pollutant degradation, whereas for the organics with electron-withdrawing group (e.g., -COOH and -NO
), hydroxyl radical (•OH) as the secondary oxidant also plays an important role. We demonstrate that the CuFeMnO-PMS system is able to achieve efficient and stable removal of the pollutants in the secondary effluent from a municipal wastewater plant at both bench and pilot scales. Moreover, we explore the application prospect of this PMS-based AOP process for large-scale wastewater treatment. This work describes an opportunity to scalably prepare robust spinel oxide catalysts for water purification and is beneficial to the practical applications of the heterogeneous PMS-AOPs.
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