A finite element method (FEM)-based simulation approach to predict the tunability in composite materials was developed and tested with analytical data. These tests showed good prediction capabilities ...of the simulation for the test data. The simulation model was then used to predict the tunability of a network-structured composite, where the dielectric phase formed clusters in a paraelectric network. This was achieved by simulating a reciprocal core-shell unit cell of said network. The simulation showed a high tunability for this network model, exceeding the tunability of the analytically evaluated layered, columnar, and particulate model. The simulation results were experimentally verified with a Ba
Sr
TiO
/Mg
B
O
(BST/MBO) composite, where core-shell granulates were made with a two-step granulation process. These structured samples showed higher tunability and dielectric loss than the unstructured samples made for comparison. Overall, the structured samples showed higher tunability to loss ratios, indicating their potential for use in tunable radio frequency applications, since they may combine high performance with little energy loss.
The Leading Group for Deepening Reform Comprehensively has been set up on the decision of the CPC Central Committee to be in charge of the overall planning of reform, taking a balanced and ...coordinated approach, advancing reform as a whole and supervising its implementation. This means that change management has become an important item on the agenda. Systematically reviewing and examining the course of the seven rounds of institutional reform introduced by the State Council since 1978 from the perspective of change management, we find that the reforms have advanced gradually and steadily, with functional transformation as the core feature and key to each round of reform. The transformation of government functions exhibits a marked two-phase character. The first phase focuses on change in government functions relating to economic management, while the second focuses on enhancing and improving macro-control systems to strengthen social management and public service functions. However, in terms of program design, the goals and measures of the past 10 years' functional transformation have clearly not been specific enough to establish a clear relationship between the three rounds of institutional reform programs and the concrete measures and their effects. Therefore, the question of whether institutional reform itself needs reform has become a new proposition for practice, one that needs to be reviewed in terms of strategic orientation, mode of implementation, public responsibilities and overall design.
Preparing concrete with unpurified sea sand and seawater is of great significance for the construction in coastal areas short of river sand and pure water. However, unpurified sea sand and seawater ...contain a lot of chloride ions which may cause steel corrosion problems. In this paper, unpurified sea sand and seawater are used to prepare ultra-high performance concrete (UHPC), and the potential differences between the steel bars with protective layer thickness of 5mm and 15mm and the Cu/CuSO
4
reference electrode under two types of dry-wet cycle and the chloride ion concentrations at different depths from UHPC specimen surface after 40 dry-wet cycles are tested, the UHPC specimens are broken to observe corrosion of embedded steel bars. The results show that UHPC prepared with unpurified sea sand and seawater has good ability to protect embedded steel reinforcement against corrosion under dry-wet cycle conditions in lab.
This experiment was performed to investigate the effects of acclimated sewage sludge (ASS) and sterilized ASS on the fates of chlorpyrifos (CP) in soil with or without cadmium (Cd), as well as the ...improvement of soil biochemical properties. Results showed that both ASS and sterilized ASS could significantly promote CP dissipation, and the groups with ASS had the highest efficiency on CP removal, whose degradation rates reached 71.3%–85.9% at the 30th day (40.4%–50.2% higher than non-sludge groups). Besides, the degradation rate of CP was not severely influenced by the existence of Cd, and the population of soil microorganism dramatically increased after adding sludge. The soil enzyme activities (dehydrogenase, acid phosphatase and FDA hydrolase activities) ranked from high to low were as follows: groups with sterilized ASS>groups with ASS>groups without sludge. Simultaneously, 16S rRNA gene sequencing revealed that ASS changed bacterial community structure and diversity in soil. In addition, alkali-hydrolyzable nitrogen and Olsen- phosphorus increased after application of sludge, indicating that the addition of ASS (or sterilized ASS) could effectively improve soil fertility.
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•Acclimated sewage sludge efficiently enhanced the dissipation of chlorpyrifos in soil.•The degradation efficiency of chlorpyrifos was not significantly affected by Cd.•The application of ASS greatly influenced the bacterial community structure in soil.•The presence of acclimated sewage sludge enhanced the soil biochemical quality.•The soil fertility improved after remediation.
BACKGROUND AND AIMSHyperuricemia has become a vital public health problem affecting the health of residents. The visceral fat area (VFA) is closely related to many chronic diseases. However, the ...association between VFA and hyperuricemia within the Chinese adult population remains nebulous. The aim of the research is to assess the relationship between VFA and serum uric acid levels.METHODS AND RESULTSFrom June 2020 to June 2021, a total of 340 Chinese adults (240 in the control group and 100 in the hyperuricemia group) were recruited from the physical examination center of Hongqi Hospital Affiliated to Mudanjiang Medical University. General demographic characteristics were collected by questionnaire. VFA was measured by a body composition analyzer, and serum biochemical indices were detected by clinical laboratory. VFA in the hyperuricemia group was higher than in the control group (P＜0.05). Further, VFA demonstrated a positive correlation with serum uric acid level (rs = 0.370, P＜0.001). To further explore this relationship, we divided the VFA into quartiles (＜P25, P25-P50, P50-P75, ≥P75). Upon comparison with the ＜P25 group, we found the VFA in the P25-P50, P50-P75, and ≥P75 groups to be associated with a substantially escalated risk of hyperuricemia, even after adjusting for age, gender, body weight, fasting plasma glucose, calcium, alanine transaminase, urea, alkaline phosphatase, and γ-glutamyltransferase. The OR and 95% CI were 2.547 (1.023, 6.341), 3.788 (1.409, 10.187) and 3.723 (1.308, 10.595), respectively (P＜0.05).CONCLUSIONVFA has a positive correlation with serum uric acid levels and may serve as a crucial predictive marker for hyperuricemia.
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•The fundamentals of DNA sensor was introduced.•The characteristics, preparation methods and influencing factors of LDHs were described.•Application progress of LDHs-based DNA sensors ...for analytical detection was summarized.
DNA sensors achieve qualitative or quantitative detection of analyte by recognizing DNA probes that bind to the target analyte and convert them into various signals. Layered double hydroxides (LDHs) have been widely used for the construction of DNA sensors due to their large specific surface area, good electrocatalytic activity and anion adsorption, and structural ease of adjustability, which in turn enable the analyte of a wide range of substances, such as DNA, RNA, and pharmaceuticals. In recent years, LDHs-based sensors have attracted widespread attention of researchers and have been used to detect various analytes. Therefore, this paper reviews the preparation and influencing factors of LDHs as well as the characteristics and types of DNA sensors, with a focus on summarizing the application of LDHs-based DNA sensors in the field of analytical detection.
The relationship between noncoding RNAs and the prognosis of bladder cancer (BC) is still controversial. The purpose of this study is to evaluate the relationship between noncoding RNAs and prognosis ...by meta-analysis.
Comprehensive retrieval of PubMed, Embase, the Cochrane Library, the Web of Science, CNKI, and WanFang databases is related to the correlation between noncoding RNAs and the prognosis of BC. Data were extracted, and the literature quality was evaluated. STATA16.0 served for the meta-analysis.
1. CircRNAs: High circ-ZFR expression led to poor overall survival (OS) of BC. 2. LncRNAs: Low lnc-GAS5 expression predicted poor OS of BC, high lnc-TUG1 expression predicted poor OS of BC. 3. MiRNAs: High miR-21 expression predicted poor OS of BC, high miR-222 expression led to poor OS of BC, high miR-155 expression predicted poor progression-free survival (PFS) of BC, high miR-143 expression caused poor PFS of BC, low miR-214 expression could result in poor recurrence-free survival (RFS) of BC.
High circ-ZFR, lnc-TUG1, miR-222, and miR-21 expressions were correlated with poor OS of BC; high miR-155 and miR-143 expression predicted poor PFS of BC; low lnc-GAS5 expression predicted poor OS of BC; low miR-214 expression predicted poor RFS of BC.
A soil bacterium designated strain JQ-41, capable of growth on fenpropathrin as the sole carbon source and energy source, was isolated from a long-term pyrethroid insecticide-treated orchard. Based ...on the morphology, physio-biochemical characteristics, and 16S rDNA gene analysis, as well as the G+C content of the genomic DNA, the strain JQ-41 was identified as Pseudomonas aeruginosa. Up to 92.3 % of 50 mg l⁻¹ fenpropathrin was degraded by P. aeruginosa strain at 30 °C and pH 7 within 7 days. The kinetic parameters q ₘₐₓ, K ₛ, and K ᵢ were established to be 1.14 day⁻¹, 38.41 mg l⁻¹, and 137.67 mg l⁻¹, respectively, and the critical inhibitor concentration was determined to be 72.72 mg l⁻¹. Cell surface hydrophobicity of P. aeruginosa strain was enhanced during growth on fenpropathrin. Three metabolites from fenpropathrin degradation were identified by gas chromatography mass spectrometry, and then a possible degradation pathway was proposed. In addition, this isolate was also able to degrade a wide range of synthetic pyrethroid insecticides including cypermethrin, deltamethrin, bifenthrin, and cyhalothrin with the degradation process following the first-order kinetic model. Taken together, our results provide insights into the kinetics and mechanism of fenpropathrin degradation by P. aeruginosa strain and also highlight its promising potential in bioremediation of pyrethroid-contaminated environment.
The bioremediation of soil co-contaminated with heavy metal and organic pollutants has attracted considerable attention in recent years.
Clitocybe maxima
(
C. maxima
), a species of mushroom ...producing the ligninolytic enzyme, was introduced into this study to evaluate the interaction of copper and 2,4,5-trichlorophenol (2,4,5-TCP) on the bioremediation potential and biochemical properties in co-contaminated soil by pot experiments. The results indicated that
C. maxima
could be considered as a candidate for the bioremediation of soil co-contaminated with copper and 2,4,5-TCP. Copper was accumulated in the fruiting body of
C. maxima
and showed a positive correlation with the initial copper concentration in the soil. A significant enhancement was found on the dissipation of 2,4,5-TCP incubated with
C. maxima
, and the removal ratios varied from 82.6 to 90.9% with the level of the co-contaminants, which were associated with the production of manganese peroxidase and dehydrogenase. Invertase, urease and dehydrogenase activities in rhizosphere declined, varying with the pollutants levels before the bioremediation, but recovered to a certain level after the bioremediation process, which demonstrated that the soil enzyme activity could be an accessible indicator for reflecting remediation effects.
The bioremediation of soil co-contaminated with heavy metal and organic pollutants has attracted considerable attention in recent years.
•Survivin as an effective diagnostic marker of bladder cancer was confirmed.•Sensitivity of survivin mRNA was higher than that of survivin protein.•Immunohistochemical detection of survivin is more ...effective for diagnosis.
Early detection, diagnosis, and treatment take on critical significance in preventing and treating bladder cancer. As indicated by numerous studies, survivin can serve as a biomarker of bladder cancer, whereas the results of a wide variety of studies have been controversial. This paper is to assess the accuracy of survivin in the diagnosis of bladder cancer by a meta-analysis. The studies regarding the diagnosis of bladder cancer using survivin were systematically retrieved from the CNKI, WanFang, CBM, VIP, Web of science, cochrane library and pubmed were extracted, and the literature quality was assessed. Meta-analysis was conducted using STATA 16.0 MP. 2,082 relevant studies were searched, and 40 studies were finally covered for meta-analysis. The pooled specificity and pooled sensitivity of survivin mRNA was 0.95 (95%CI: 0.91, 0.97) and 0.94 (95%CI: 0.88, 0.97). The pooled specificity and pooled sensitivity of survivin protein reached 0.95 (95%CI: 0.90, 0.97) and 0.87 (95%CI: 0.78, 0.92). The pooled positive likelihood ratio, pooled negative likelihood ratio, the area under the curve, and diagnostic odds ratio for survivin mRNA reached 17.7 (95%CI: 10.3, 30.6), 0.07 (95%CI: 0.04, 0.12), 0.98 (95%CI: 0.97, 0.99) and 266 (95%CI: 114, 621), respectively. For survivin protein was 16.4 (95%CI: 7.9, 33.9), 0.14 (95%CI: 0.08, 0.24), 0.97 (95%CI: 0.95, 0.98) and 117 (95%CI: 38, 357), respectively. Survivin takes on great significance in diagnosing bladder cancer. However, due to some limitations in the number and quality of covered studies, this conclusion should be validated through additional higher quality clinical studies.
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