Theoretical predictions of the ideal strength of materials range from E/30 to E/10 (E is Young's modulus). However, despite intense interest over the last decade, the value of the ideal strength ...achievable through experiments for metals remains a mystery. This study showcases the remarkable spall strength of Cu
Zr
amorphous alloy that exceeds the E/10 limit at strain rates greater than 10
s
through laser-induced shock experiments. The material exhibits a spall strength of 11.5 GPa, approximately E/6 or 1/13 of its P-wave modulus, which sets a record for the elastic limit of metals. Electron microscopy and large-scale molecular dynamics simulations reveal that the primary failure mechanism at extreme strain rates is void nucleation and growth, rather than shear-banding. The rate dependence of material strength is explained by a void kinetic model controlled by surface energy. These findings help advance our understanding on the mechanical behavior of amorphous alloys under extreme strain rates.
The disparity between human and machine perception of spatial information presents a challenge for machines to accurately sense their surroundings and improve target detection performance. ...Cross-modal data fusion emerges as a potential solution to enhance the perceptual capabilities of systems. This article introduces a novel spatial perception method that integrates dual-modality feature fusion and coupled attention mechanisms to validate the improvement in detection performance through cross-modal information fusion. The proposed approach incorporates cross-modal feature extraction through a multi-scale feature extraction structure employing a dual-flow architecture. Additionally, a transformer is integrated for feature fusion, while the information perception of the detection system is optimized through the utilization of a linear combination of loss functions. Experimental results demonstrate the superiority of our algorithm over single-modality target detection using visible images, exhibiting an average accuracy improvement of 30.4%. Furthermore, our algorithm outperforms single-modality infrared image detection by 3.0% and comparative multimodal target detection algorithms by 3.5%. These results validate the effectiveness of our proposed algorithm in fusing dual-band features, significantly enhancing target detection accuracy. The adaptability and robustness of our approach are showcased through these results.
Cryo-electron microscopy (cryo-EM) visualizes the atomic structure of macromolecules that are embedded in vitrified thin ice at their close-to-native state. However, the homogeneity of ice thickness, ...a key factor to ensure high image quality, is poorly controlled during specimen preparation and has become one of the main challenges for high-resolution cryo-EM. Here we found that the uniformity of thin ice relies on the surface flatness of the supporting film, and developed a method to use ultraflat graphene (UFG) as the support for cryo-EM specimen preparation to achieve better control of vitreous ice thickness. We show that the uniform thin ice on UFG improves the image quality of vitrified specimens. Using such a method we successfully determined the three-dimensional structures of hemoglobin (64 kDa), α-fetoprotein (67 kDa) with no symmetry, and streptavidin (52 kDa) at a resolution of 3.5 Å, 2.6 Å and 2.2 Å, respectively. Furthermore, our results demonstrate the potential of UFG for the fields of cryo-electron tomography and structure-based drug discovery.
Abstract
One-pot synthesis of heterocyclic aromatics with good optical properties from phenolic β-O-4 lignin segments is of high importance to meet high value added biorefinery demands. However, ...executing this process remains a huge challenge due to the incompatible reaction conditions of the depolymerization of lignin β-O-4 segments containing γ-OH functionalities and bioresource-based aggregation-induced emission luminogens (BioAIEgens) formation with the desired properties. In this work, benzannulation reactions starting from lignin β-O-4 moieties with 3-alkenylated indoles catalyzed by vanadium-based complexes have been successfully developed, affording a wide range of functionalized carbazoles with up to 92% yield. Experiments and density functional theory calculations suggest that the reaction pathway involves the selective cleavage of double C-O bonds/Diels-Alder cycloaddition/dehydrogenative aromatization. Photophysical investigations show that these carbazole products represent a class of BioAIEgens with twisted intramolecular charge transfer. Distinctions of emission behavior were revealed based on unique acceptor-donor-acceptor-type molecular conformations as well as molecular packings. This work features lignin β-O-4 motifs with γ-OH functionalities as renewable substrates, without the need to apply external oxidant/reductant systems. Here, we show a concise and sustainable route to functional carbazoles with AIE properties, building a bridge between lignin and BioAIE materials.
Most of malignant external otitis (MEO) cases reported in the literature are attributed to
. Fungal infections in MEO are also likely but extremely rare. And conventional microbiology tests is ...difficult to diagnose.
Two patients were diagnosed with Fungal malignant external otitis (FMEO) due to
by metagenomic Next-Generation Sequencing (mNGS) and recovered after comprehensive treatment including operation and voriconazole. The antifungal treatment was delayed due to repeated cultures of secretions being negative and pathological examination showed granulation tissue proliferation with extensive neutrophil infiltration.
mNGS might be helpful for patients suspected with FMEO, especially when conventional microbiology tests were negative.
Near-infrared dyes were developed to be contrast agents due to their ability to improve the productivity of photoacoustic (PA) imaging and photothermal therapy (PTT) treatments. During the article, ...we described in detail the PA and PT effects of a category of organic molecules. F
-TCNQ could potentially cause a red-shift in the peak PA intensity. The results show that the PTT intensity of the near-infrared dyes with phenyl groups were higher than near-infrared dyes with thiophene groups. We also investigated the photodynamic treatment effect of C1b to demonstrate that these dyes are highly desirable in biochemistry. The high photoacoustic intensity of the organic molecules and the good yield of reactive oxygen species could indicate that these dyes have good potential for a wide range of imaging applications. Finally, we embedded the dye (C1b) in a liposomal hydrophobic phospholipid bilayer (C1b⊂L) to facilitate the application of hydrophobic dyes in biomedical applications, which can be absorbed by cells with good compatible and high stability for the imaging of cellular PA.
The molecular structure, luminescence behavior, and electronic energy level of an organic optoelectronic materials are important parameters for its synthesis. The electro-optical properties can be ...changed by modifying the structure of the molecule to make the electronic energy level adjustable. In this article, a series of organic conjugated micro-molecules are successfully synthesized by linking small compound units. This metal-free 2 + 2 click chemistry process generates donor-acceptor chromophore substances with high yield, high solubility, and adjustable energy levels, which can be widely used for sensors and nonlinear optics in different fields. A-TCNE, A-TCNQ, and A-F4-TCNQ molecules are characterized comprehensively via UV-Vis-NIR spectra,
H NMR spectra, infrared spectroscopy, and mass spectrometry. The unique nonlinear optical phenomena and powerful intra-molecular charge-transfer interactions of these new materials give them fascinating potential for application as optoelectronic materials.
Intercellular communication is essential for almost all physiological and pathological processes. Endothelial cell (EC)-derived exosomes, working as mediators for intercellular information exchange, ...are involved in the pathophysiological mechanisms of atherosclerosis. However, the effect of inflamed endothelial exosomes on the function of macrophages (Mϕ) is poorly defined. This study aims to unravel how exosomes derived from tumor necrosis factor-α (TNF-α)-stimulated ECs (exo-T) affect Mϕ
.
Exosomes derived from untreated ECs (exo) and exo-T were identified by using TEM, NTA, and western blot, and we observed that PKH67-labeled exo/exo-T were taken up by Mϕ. Exposure to exo-T for 24 h not only skewed Mϕ to the M1 subtype and exacerbated lipid deposition, but also promoted Mϕ apoptosis, while it did not significantly affect Mϕ migration, as detected by RT-qPCR, Dil-ox-LDL uptake assay, flow cytometry, wound healing assay, and transwell assay, respectively. In addition, exo/exo-T-related microRNA-Seq revealed 104 significantly differentially expressed microRNAs (DE-miRNAs). The target genes of DE-miRNAs were mainly enriched functionally in metabolic pathways, MAPK signaling pathway, etc., as determined using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. We further demonstrated by immunoblotting that exo-T intervention improves the phosphorylation of MAPK/NF-κB-related proteins.
Collectively, this study reveals that inflamed endothelial exosomes (TNF-α-stimulated EC-derived exosomes) work as a functional mediator to affect Mϕ function and may activate Mϕ through MAPK/NF-κB signaling pathways.
Jiangsu coastal wetland has the largest area of the invasive plant, Spartina alterniflora (S. alterniflora), in China. S. alterniflora has been present in the wetland for nearly 40 years and poses a ...substantial threat to the safety of coastal wetland ecosystems. There is an urgent need to control the distribution of S. alterniflora. The biological characteristics of the invasion process of S. alterniflora contribute to its multi-scale distribution. However, the current classification methods do not deal successfully with multi-scale problems, and it is also difficult to perform high-precision land cover classification on multi-temporal remote sensing images. In this study, based on Landsat data from 1990 to 2020, a new deep learning multi-scale residual convolutional neural network (MRCNN) model was developed to identify S. alterniflora. In this method, features at different scales are extracted and concatenated to obtain multi-scale information, and residual connections are introduced to ensure gradient propagation. A multi-year data unified training method was adopted to improve the temporal scalability of the MRCNN. The MRCNN model was able to identify the annual S. alterniflora distribution more accurately, overcame the disadvantage that traditional CNNs can only extract feature information at a single scale, and offered significant advantages in spatial characterization. A thematic map of S. alterniflora distribution was obtained. Since it was introduced in 1982, the distribution of S. alterniflora has expanded to approximately 17,400 ha. In Jiangsu, the expansion process of S. alterniflora over time was divided into three stages: the growth period (1982–1994), the outbreak period (1995–2004), and the plateau period (2005–2020). The spatial expansion direction was mainly parallel and perpendicular to the coastline. The hydrodynamic conditions and tidal flat environment on the coast of Jiangsu Province are suitable for the growth of S. alterniflora. Reclamation of tidal flats is the main factor affecting the expansion of S. alterniflora.
Bilayer graphene (BLG) is intriguing for its unique properties and potential applications in electronics, photonics, and mechanics. However, the chemical vapor deposition synthesis of large-area ...high-quality bilayer graphene on Cu is suffering from a low growth rate and limited bilayer coverage. Herein, we demonstrate the fast synthesis of meter-sized bilayer graphene film on commercial polycrystalline Cu foils by introducing trace CO
during high-temperature growth. Continuous bilayer graphene with a high ratio of AB-stacking structure can be obtained within 20 min, which exhibits enhanced mechanical strength, uniform transmittance, and low sheet resistance in large area. Moreover, 96 and 100% AB-stacking structures were achieved in bilayer graphene grown on single-crystal Cu(111) foil and ultraflat single-crystal Cu(111)/sapphire substrates, respectively. The AB-stacking bilayer graphene exhibits tunable bandgap and performs well in photodetection. This work provides important insights into the growth mechanism and the mass production of large-area high-quality BLG on Cu.
