Die Postmoderne ist zu Ende! Seit drei Dekaden hallt diese Diagnose durch den geisteswissenschaftlichen Diskursraum. Doch was kommt jetzt? Die Beiträger*innen des Bandes schlagen kein neues ...Epochenkonzept vor, sondern widmen sich den Phänomenen Postironie, Pop III, Heimat und Posthumanismus. Mit Hilfe kulturwissenschaftlichen Rüstzeugs klopfen sie zeitgenössische Filme, Serien und Romane auf ihr gegenwartsspezifisches Potenzial ab. Grimes, David Bowie und Olivia Wenzel werden dabei ebenso behandelt wie Donna Haraway, Andreas Gabalier und Leif Randt.
Background and purpose
Acute ischemic stroke has increasingly become a procedural disease following the demonstrated benefit of mechanical thrombectomy (MT) for emergent large vessel occlusion (ELVO) ...on clinical outcomes and tissue salvage in randomized trials. Given these data and anecdotal experience of decreased numbers of decompressive hemicraniectomies (DHCs) performed for malignant cerebral edema, we sought to correlate the numbers of strokes, thrombectomies, and DHCs performed over the timeline of the 2013 failed thrombolysis/thrombectomy trials, to the 2015 modern randomized MT trials, to post-DAWN and DEFUSE 3.
Materials and methods
This is a multicenter retrospective compilation of patients who presented with ELVO in 11 US high-volume comprehensive stroke centers. Rates of tissue plasminogen activator (tPA), thrombectomy, and DHC were determined by current procedural terminology code, and specificity to acute ischemic stroke confirmed by each institution. Endpoints included the incidence of stroke, thrombectomy, and DHC and rates of change over time.
Results
Between 2013 and 2018, there were 55,247 stroke admissions across 11 participating centers. Of these, 6145 received tPA, 4122 underwent thrombectomy, and 662 patients underwent hemicraniectomy. The trajectories of procedure rates over time were modeled and there was a significant change in MT rate (p = 0.002) without a concomitant change in the total number of stroke admissions, tPA administration rate, or rate of DHC.
Conclusions
This real-world study confirms an increase in thrombectomy performed for ELVO while demonstrating stable rates of stroke admission, tPA administration and DHC. Unlike prior studies, increasing thrombectomy rates were not associated with decreased utilization of hemicraniectomy.
The use of shear to control the microstructure in the lyotropic lamellar region of a ternary isothermal poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (Pluronic ...P123)/water/butanol system was investigated by means of small angle neutron and light scattering (SANS, SALS), birefringence, and rheology. A transition from parallel to perpendicular alignment of lamellae, with a corresponding decrease in the viscosity, was found with increasing shear rate at high block copolymer concentrations. At low polymer content, however, the samples were shear thickening, and a shear-induced formation of multilamellar vesicles (“onions”) was observed for the first time in block copolymer systems.
Reduced weathering rates due to the lack of liquid water and significantly greater typical surface ages should result in a higher density of meteorites on the surface of Mars compared to Earth. ...Several meteorites were identified among the rocks investigated during Opportunity's traverse across the sandy Meridiani plains. Heat Shield Rock is a IAB iron meteorite and has been officially recognized as “Meridiani Planum.” Barberton is olivine‐rich and contains metallic Fe in the form of kamacite, suggesting a meteoritic origin. It is chemically most consistent with a mesosiderite silicate clast. Santa Catarina is a brecciated rock with a chemical and mineralogical composition similar to Barberton. Barberton, Santa Catarina, and cobbles adjacent to Santa Catarina may be part of a strewn field. Spirit observed two probable iron meteorites from its Winter Haven location in the Columbia Hills in Gusev Crater. Chondrites have not been identified to date, which may be a result of their lower strengths and probability to survive impact at current atmospheric pressures. Impact craters directly associated with Heat Shield Rock, Barberton, or Santa Catarina have not been observed, but such craters could have been erased by eolian‐driven erosion.
Fully stereodivergent dual‐catalytic α‐allylation of protected α‐amino‐ and α‐hydroxyacetaldehydes is achieved through iridium‐ and amine‐catalyzed substitution of racemic allylic alcohols with ...chiral enamines generated in situ. The operationally simple method furnishes useful aldehyde building blocks in good yields, more than 99 % ee, and with d.r. values greater than 20:1 in some cases. Additionally, the γ,δ‐unsaturated products can be further functionalized in a stereodivergent fashion with high selectivity and with preservation of stereochemical integrity at the Cα position.
Die Ir‐katalysierte allylische Substitution racemischer Allylalkohole mit in situ erzeugten chiralen Enaminen ermöglicht die komplett stereodivergente Titelreaktion. α‐N/O‐substituierte γ,δ‐ungesättigte Aldehyde werden hoch enantioselektiv in guten Ausbeuten erhalten. Phth=Phthalimid; cod=1,5‐Cyclooctadien; Ts=p‐Toluolsulfonyl; DCE=1,2‐Dichlorethan.
In this Letter, an incorrect version of the Supplementary Information file was inadvertently used, which contained several errors. The details of references 59-65 were missing from the end of the ...Supplementary Discussion section on page 4. In addition, the section 'Text 3. Y2H on ICD interactions' incorrectly referred to 'Extended Data Fig. 4d' instead of 'Extended Data Fig. 3d' on page 3. Finally, the section 'Text 4. Interaction network analysis' incorrectly referred to 'Fig. 1b and Extended Data Fig. 6' instead of 'Fig. 2b and Extended Data Fig. 7' on page 3. These errors have all been corrected in the Supplementary Information.
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