A modular approach for the synthesis of highly ordered porous and chiral auxiliary (Evans auxiliary) decorated metal-organic frameworks is developed. Our synthesis strategy, which uses known porous ...structures as model materials for incorporation of chirality via linker modification, can provide access to a wide range of porous materials suitable for enantioselective separation and catalysis. Chiral analogues of UMCM-1 have been synthesized and investigated for the enantioseparation of chiral compounds in the liquid phase and first promising results are reported.
Low-cost, portable RGB-D cameras with integrated body tracking functionality enable easy-to-use 3D motion analysis without requiring expensive facilities and specialized personnel. However, the ...accuracy of existing systems is insufficient for most clinical applications. In this study, we investigated the concurrent validity of our custom tracking method based on RGB-D images with respect to a gold-standard marker-based system. Additionally, we analyzed the validity of the publicly available Microsoft Azure Kinect Body Tracking (K4ABT). We recorded 23 typically developing children and healthy young adults (aged 5 to 29 years) performing five different movement tasks using a Microsoft Azure Kinect RGB-D camera and a marker-based multi-camera Vicon system simultaneously. Our method achieved a mean per joint position error over all joints of 11.7 mm compared to the Vicon system, and 98.4% of the estimated joint positions had an error of less than 50 mm. Pearson's correlation coefficients r ranged from strong ( r =0.64) to almost perfect ( r >0.99). K4ABT demonstrated satisfactory accuracy most of the time but showed short periods of tracking failures in nearly two-thirds of all sequences limiting its use for clinical motion analysis. In conclusion, our tracking method highly agrees with the gold standard system. It paves the way towards a low-cost, easy-to-use, portable 3D motion analysis system for children and young adults.
ABSTRACT
Compact Galactic Binary Systems with orbital periods of a few hours are expected to be detected in gravitational waves (GW) by Laser Interferometer Space Antenna (LISA) or a similar mission. ...At present, these so-called verification binaries provide predictions for GW frequency and amplitude. A full polarization prediction would provide a new method to calibrate LISA and other GW observatories, but requires resolving the orientation of the binary on the sky, which is not currently possible. We suggest a method to determine the elusive binary orientation and hence predict the GW polarization, using km-scale optical intensity interferometry. The most promising candidate is CD–30° 11223, consisting of a hot helium subdwarf with mB = 12 and a much fainter white dwarf companion, in a nearly edge-on orbit with period 70.5 min. We estimate that the brighter star is tidally stretched by 6 per cent. Resolving the tidal stretching would provide the binary orientation. The resolution needed is far beyond any current instrument, but not beyond current technology. We consider scenarios where an array of telescopes with km-scale baselines and/or the Very Large Telescope (VLT) and Extremely Large Telescope (ELT) are equipped with recently developed kilopixel sub-ns single-photon counters and used for intensity interferometry. We estimate that a team-up of the VLT and ELT could measure the orientation to ±1° at 2σ confidence in 24 h of observation.
Equinus deformity with or without concomitant drop foot is a common finding in children with unilateral spastic cerebral palsy and spastic hemiplegia of other causes. Hypothetically, these ...deformities may lead to pelvic retraction and hip internal rotation during gait. Orthoses are used to reduce pes equinus during gait and to restore hindfoot first contact.
We aimed to investigate whether the use of orthotic equinus correction reduces rotational hip and pelvic asymmetries.
In a retrospective study, 34 children with unilateral spastic cerebral palsy or spastic hemiplegia of other causes underwent standardized instrumented 3D gait analysis with and without orthotic equinus management. We analyzed the differences in the torsional profile during barefoot walking and while wearing orthoses, as well as investigated the influence of ankle dorsiflexion and femoral anteversion on pelvic and hip kinematics and hip kinetics.
Wearing orthoses corrected pes equinus and pelvic internal rotation at the end of the stance phase and in the swing phase compared to barefoot walking. Hip rotation and the rotational moment did not significantly change with orthoses. Orthotic management or femoral anteversion did not correlate to pelvic and hip asymmetry.
The findings indicate that the correction of the equinus by using orthoses had a variable effect on the asymmetry of the hip and pelvis and internal rotation; both appear to have a multifactorial cause that is not primarily driven by the equinus component.
The Andago is a rehabilitation robot that allows training walking over-ground while providing bodyweight unloading (BWU). We investigated the practicability, acceptability, and appropriateness of the ...device in children with gait impairments undergoing neurorehabilitation. Concerning appropriateness, we investigated whether (i) stride-to-stride variability of the stride time and inter-joint coordination was higher when walking over-ground in Andago versus treadmill walking, and (ii) activation of antigravity leg muscles decreased with higher levels of BWU.
Eighteen children and adolescents with gait impairments participated in three sessions. Practicability was assessed by determining the time needed to get a patient in and out of Andago, the accuracy of the BWU system, and other aspects. Acceptability was assessed by patients responding to questions, while six therapists filled out the System Usability Scale. To determine appropriateness, the participants were equipped with surface electromyography (sEMG) electrodes, electrogoniometers and accelerometers. Various parameters were compared between walking over-ground and on a treadmill, and between walking with three different levels of BWU (median: 20%, 35% and 50% of the bodyweight) over-ground.
Practicability: the average time needed to get in and out of Andago amounted to 60 s and 16 s, respectively. The BWU system seemed accurate, especially at higher levels. We experienced no technical difficulties and Andago prevented 12 falls. However, participants had difficulties walking through a door without bumping into it. Acceptability: after the second session, nine participants felt safer walking in Andago compared to normal walking, 15 preferred walking in Andago compared to treadmill walking, and all wanted to train again with Andago. Therapists rated the usability of the Andago as excellent. Appropriateness: stride-to-stride variability of stride duration and inter-joint coordination was higher in Andago compared to treadmill walking. sEMG activity was not largely influenced by the levels of BWU investigated in this study, except for a reduced M. Gluteus Medius activity at the highest level of BWU tested.
The Andago is a practical and well-accepted device to train walking over-ground with BWU in children and adolescents with gait impairments safely. The system allows individual stride-to-stride variability of temporospatial gait parameters without affecting antigravity muscle activity strongly.
ClinicalTrials.gov Identifier: NCT03787199.
Local antimicrobial susceptibility surveys are crucial for optimal empirical therapy guidelines and for aiding in antibiotic stewardship and treatment decisions. For many laboratories, a ...comprehensive overview of local antimicrobial susceptibility patterns of anaerobic bacteria is still lacking due to the long incubation time and effort involved. The present study investigates the antimicrobial susceptibility patterns and related clinical and demographic data of 2856 clinical isolates of anaerobic bacteria that were submitted for analysis to the Institute for Medical Microbiology and Hygiene of the Freiburg University Medical Center (a tertiary university medical center in Southern Germany) between 2015 and 2019. Antimicrobial susceptibility testing has been carried out according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guideline. Minimum inhibitory concentration (MIC)50 and MIC90 for penicillin, metronidazole, moxifloxacin, and clindamycin were established for Gram-positive anaerobes and for ampicillin-sulbactam, meropenem, metronidazole, moxifloxacin, and clindamycin for Gram-negative anaerobes. The distribution of MIC-values for various antibiotics against anaerobic bacteria was also established, especially for those having no specific breakpoints according to EUCAST guidelines. Most clinically relevant anaerobic bacteria originated from general surgery, neurological, and orthopedic wards. A high proportion of isolates were resistant to moxifloxacin and clindamycin indicating the importance of their susceptibility testing before administration. Based on our study metronidazole and other β-lactam/β-lactamase inhibitor combinations such as ampicillin-sulbactam remain suitable for empirical treatment of infections with anaerobic bacteria.
The standard theoretical description Θ(n^) of the observed cosmic microwave background (CMB) temperature anisotropies is gauge dependent. It is, however, well known that the gauge mode is limited to ...the monopole and that the higher angular multipoles Θl (l≥1) are gauge invariant. Several attempts have been made in the past to properly define the monopole fluctuation, but the resulting values of the monopole power C0 are infinite due to the infrared divergences. The infrared divergences arise from the contribution of the uniform gravitational potential to the monopole fluctuation, in violation of the equivalence principle. Here we present the gauge-invariant theoretical description of the observed CMB temperature anisotropies and compute the monopole power C0=1.66×10−9 in a ΛCDM model. While the gauge dependence in the standard calculations originates from the ambiguity in defining the hypersurface for the background CMB temperature T¯ today, it is in fact well defined and one of the fundamental cosmological parameters. We argue that once the cosmological parameters are chosen, the monopole fluctuation can be unambiguously inferred from the angle average of the observed CMB temperature, making it a model-dependent "observable." Adopting simple approximations for the anisotropy formation, we derive a gauge-invariant analytical expression for the observed CMB temperature anisotropies to study the CMB monopole fluctuation and the cancellation of the uniform gravitational potential contributions on large scales.
Background: The simultaneous occurrence of cerebellopontine angle (CPA) meningioma and vestibular schwannoma (VS) in the absence of neurofibromatosis type 2 or history of irradiation is very rare. We ...report a case with coexistent CPA meningioma and VS, which were radiologically not distinguishable in preoperative imaging. Case Description: A 46-year-old female presented with acute hearing loss, tinnitus and gait ataxia. Otorhinolaryngological diagnostic workup and imaging studies showed an intra- and extrameatal homogenous contrast enhancing lesion. The neuroradiological diagnosis was VS. The patient was operated via the retrosigmoid approach. Intraoperatively two distinct tumors were found: a small, mainly intrameatally located VS and a larger meningioma originating from the dura of the petrous bone. Both tumors were completely microsurgically removed. The patient experienced no new neurological deficit after surgery; particularly facial nerve function was completely preserved. Histopathological examination revealed a fibromatous meningioma and a VS, respectively. Conclusions: The coincidental occurrence of CPA meningioma and VS is very rare. Careful interpretation of imaging studies before surgery is crucial. Even such rare cases should be kept in mind when discussing the therapeutic options with the patient. More studies are needed for a better understanding of mechanisms leading to multiple tumor growth.
Recent analysis of the Planck measurements opened a possibility that we live in a non-flat universe. Given the renewed interest in non-zero spatial curvature, here we re-visit the light propagation ...in a non-flat universe and provide the gauge-invariant expressions for the cosmological probes: the luminosity distance, galaxy clustering, weak gravitational lensing, and cosmic microwave background anisotropies. With the positional dependence of the spatial metric, the light propagation in a non-flat universe is much more complicated than in a flat universe. Accounting for all the relativistic effects and including the vector and tensor contributions, we derive the expressions for the cosmological probes and explicitly verify their gauge invariance. We compare our results to previous work in a non-flat universe, if present, but this work represents the first comprehensive investigation of the cosmological probes in a non-flat universe. Our theoretical formalism in a non-flat universe will play a crucial role in constraining the spatial curvature in the upcoming large-scale surveys.
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