Interstitial granulomatous drug reaction (IGDR) is a distinct inflammatory process that often presents as annular, violaceous plaques distributed on the extremities, proximal trunk, and ...intertriginous areas. The list of drugs implicated for inciting IGDR is growing, but most prominently includes ACE inhibitors, antihistamines, beta-blockers, antidepressants, and anticonvulsants. Ustekinumab is a human monoclonal antibody that targets inflammatory cytokines IL-12 and IL-23 and has been have shown to be effective in treating IGDR. However, we present a case that suggests ustekinumab can also act as an inciting agent for IGDR.
The considerably improved facilities for determining crystal structures, making use of electronic computers, has resulted in a large number of structure analyses of minerals in the last six years. ...Many new structures have been determined, and previously known structures have been re-determined with greater accuracy. Although the new structures are largely of less common minerals, important new principles of structure building have been discovered for chain silicates and for zeolites. The finer details of the structures of the layered silicates and of the feldspars are important aids to the understanding of polymorphism, solid solution, thermal relationships and paragenesis.
Shingles, also known as herpes zoster, is a common disease in the elderly population that is caused by reactivation of latent varicella zoster virus. Its manifestations and complications can lead to ...significant short- and long-term morbidity. In 2006, the United States Food and Drug Administration approved Zoster Vaccine Live (Zostavax) for the prevention of herpes zoster in immunocompetent adults age 60 and over. The approval was based on the results ofa large, multi-center clinical trial, the Shingles Prevention Study. This study showed that vaccination significantly decreased shingles incidence, burden of illness due to disease, and the development of, and severity of postherpetic neuralgia. This review offers an overview of varicella zoster virus infection and complications, a summary of the Shingles Prevention Study, and a critical analysis designed to aid the practicing physician who has questions about vaccine administration.
Medicine and Mineralogy [and Discussion] Gilson, J. C.; Tait, Nancy; Zussman, J. ...
Philosophical transactions of the Royal Society of London. Series A: Mathematical and physical sciences,
09/1977, Letnik:
286, Številka:
1336
Journal Article
Recenzirano
The article deals with the health hazards caused by mineral dusts, and by asbestos fibres in the induction of cancers in particular. Mineral dusts cause damage by inhalation, rarely by ingestion or ...ingress into the skin. In the lung, bronchitis, fibrosis (pneumoconiosis), and cancers may result. Few mineral dusts cause cancers, and asbestos is unique in causing two separate types within the lung. Epidemiological and other studies of groups of asbestos workers have shown important differences in risk with the type of fibre and the type of job. All types of asbestos cause fibrosis and an excess of bronchial cancers which are, however, also closely cigarette related. Crocidolite is especially related to cancers of the surface of the lung (mesotheliomas). Mining and milling of chrysotile, the most used type of asbestos, have caused few mesotheliomas, despite heavy dust exposures in the past. The diseases induced by asbestos are dose-related. Where it has been possible to divide the groups of asbestos workers into those with different levels of past exposure, the least exposed groups have shown small or no excess of asbestos-related diseases despite their exposures having been considerably higher than that likely to have been encountered by the general public. Present evidence indicates that the general public have not been at risk of asbestos-related diseases, but more evidence is required about the proportion of all mesotheliomas which are related to asbestos. The new techniques of mineralogy when applied at a micro level to the dust in tissues, and particularly in the lung, may be of great help in answering this important problem. Some comparisons of the mortality from occupationally related cancers, accidents, smoking habits, and general diseases are given. Current research into the biomedical effects of natural fibrous mineral dusts is likely to be of great value in ensuring that the new man made mineral fibres now being developed are manufactured and used under circumstances which will cause no ill effects to health.
Mineral dusts are pollutants in air, drinking water, foodstuffs and even some drugs. Inhalation of the asbestos minerals amosite, anthophyllite, chrysotile, crocidolite and tremolite occurs not only ...in areas adjacent to industrial and mining activities and in the households of those industrially exposed to these minerals, but also by the general public due both to airborne dusts from industrial areas, mines and mine dumps and to the household use of asbestos-containing commodities such as talcum-powders and do-it-yourself plasters, fillers and insulation material. Inorganic particles are also inhaled in cigarette and cigar smoke. These include cristobalite - a known fibrogen - and result from use, during manufacture, of clay minerals, diatomaceous earth, glass fibre and other additives. Ingestion of asbestos minerals has resulted from the dumping of the gangue of taconite ores into water supplies. Both talc and asbestos are ingested from toiletries and other household commodities as well as in foods such as rice coated with mineral dust. With some of the mineral dusts in the environment being known carcinogens, or associated with other diseases, their identification and the determination of their sources are important aspects of environmental health.
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