A review of Gaston Franssen, Rick Honings (eds.), Idolizing Authorship: Literary Celebrity and the Construction of Identity, 1800 to the Present, Amsterdam University Press, Amsterdam, 2017, 282 pp. ...€ 89.
Zinc homeostasis is crucial for bacterial cells, since imbalances affect viability. However, in mycobacteria, knowledge of zinc metabolism is incomplete.
(MSMEG) is an environmental, nonpathogenic
...that is widely used as a model organism to study mycobacterial metabolism and pathogenicity. How MSMEG maintains zinc homeostasis is largely unknown. SmtB and Zur are important regulators of bacterial zinc metabolism. In mycobacteria, these regulators are encoded by an operon, whereas in other bacterial species, SmtB and Zur are encoded on separate loci. Here, we show that the
-
operon is consistently present within the genus
but otherwise found only in
,
, and
By RNA deep sequencing, we determined the Zur and SmtB regulons of MSMEG and compared them with transcriptional responses after zinc starvation or excess. We found an exceptional genomic clustering of genes whose expression was strongly induced by
deletion and zinc starvation. These genes encoded zinc importers such as ZnuABC and three additional putative zinc transporters, including the porin MspD, as well as alternative ribosomal proteins. In contrast, only a few genes were affected by deletion of
and zinc excess. The zinc exporter ZitA was most prominently regulated by SmtB. Moreover, transcriptional analyses in combination with promoter and chromatin immunoprecipitation assays revealed a special regulation of the
-
operon itself: an apparently zinc-independent, constitutive expression of
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resulted from sensitive coregulation by both SmtB and Zur. Overall, our data revealed yet unknown peculiarities of mycobacterial zinc homeostasis.
Zinc is crucial for many biological processes, as it is an essential cofactor of enzymes and a structural component of regulatory and DNA binding proteins. Hence, all living cells require zinc to maintain constant intracellular levels. However, in excess, zinc is toxic. Therefore, cellular zinc homeostasis needs to be tightly controlled. In bacteria, this is achieved by transcriptional regulators whose activity is mediated via zinc-dependent conformational changes promoting or preventing their binding to DNA. SmtB and Zur are important antagonistically acting bacterial regulators in mycobacteria. They sense changes in zinc concentrations in the femtomolar range and regulate transcription of genes for zinc acquisition, storage, and export. Here, we analyzed the role of SmtB and Zur in zinc homeostasis in
Our results revealed novel insights into the transcriptional processes of zinc homeostasis in mycobacteria and their regulation.
1984 m. lapkričio 13 d. LTSR MA Filosofijos, sociologijos ir teisės institute KMI Filosofijos ir mokslinio komunizmo katedros vyr. dėstytoja Zita Liubarskienė apgynė filosofijos mokslų kandidato ...disertaciją „Dorovės ir religijos santykio problema Lietuvos filosofinės minties istorijoje (1945–1980)“. Disertacijos moksliniai vadovai – prof. J. Barzdaitis ir doc. V. Žemaitis, oficialieji oponentai: prof. J. Minkevičius ir doc. N. Juršėnas.
The Lay Saint Doyno, Mary Harvey
2019, 2019-10-15
eBook
In The Lay Saint, Mary Harvey Doyno investigates the phenomenon of saintly cults that formed around pious merchants, artisans, midwives, domestic servants, and others in the medieval communes of ...northern and central Italy. Drawing on a wide array of sources— vitae documenting their saintly lives and legends, miracle books, religious art, and communal records—Doyno uses the rise of and tensions surrounding these civic cults to explore medieval notions of lay religiosity, charismatic power, civic identity, and the church's authority in this period. Although claims about laymen's and laywomen's miraculous abilities challenged the church's expanding political and spiritual dominion, both papal and civic authorities, Doyno finds, vigorously promoted their cults. She shows that this support was neither a simple reflection of the extraordinary lay religious zeal that marked late medieval urban life nor of the Church's recognition of that enthusiasm. Rather, the history of lay saints' cults powerfully illustrates the extent to which lay Christians embraced the vita apostolic —the ideal way of life as modeled by the Apostles—and of the church's efforts to restrain and manage such claims.
Provider: - Institution: - Data provided by Europeana Collections- Zita Gaier- Zita Gaier- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 ...Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- Zita Gaier in "Sunburned" (2019)- Zita Gaier in "Sunburned" (2019)- All metadata published by Europeana are available free of ...restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- Filmplakat von "Sunburned" (2019)- German movie poster of "Sunburned" (2019)- All metadata published by Europeana are available free ...of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Este artigo se concentra em um tipo particular de narrativa sobre servos,¹ as Vidas de servos sagrados. Em particular, foca a vida de uma santa medieval, Zita de Lucca, que viveu no século XIV. ...Mostra como sua imagem foi modificada com o objetivo de transformá-la em um modelo a ser imitado, especialmente pelos servos, entre os séculos XVI e XVIII. Descreve a estratégia elaborada pela Igreja Católica, nos séculos XVI e XVII, para impedir a disseminação da Reforma Protestante, dando atenção particular ao papel dado à hagiografia. Aponta como a história de Zita pode se ajustar à política de restauração moral e religiosa buscada pela Igreja Católica entre os séculos XIX e XX. Analisa como a mesma história foi contada de várias maneiras em diversos contextos culturais e sociais e por autores com objetivos diferentes. Nesse sentido, após analisar a "história das histórias de Zita", o artigo chama a atenção para as transformações socioeconômicas por que passaram os serviços domésticos, particularmente no que diz respeito ao aumento das taxas de feminilidade entre os mesmos, tentando entender as implicações e conseqüências mais gerais desse aumento à luz da História Social e de Gênero.This article aims to discuss on a particular type of narrative about servants, the Lifes of holy servants. In particular it will focus on the Lives of a medieval saint, Zita of Lucca, that lived in the 14th century. It will show how her image was modified in order to transform it into a model to be imitated, special by servants, between the 16th and the 18th centuries. It will also describe the strategy elaborated by the Catholic Church in the 16th and the 17th centuries in order to reform its body and in order to arrest the spreading of the Protestant Reformation, paying particular attention to the role attributed to hagiography. Zita's story could suit the police of moral and religious restoration pursued by the Catholic Church in the 19th and part of the 20th centuries. It will analyze how the same story has been told differently in different cultural and social contexts and by authors who were pursuing different aims. After analyze the "story of Zita's stories", it will discuss the socio-economic transformations of domestic service, in particular on its feminization, trying to understand the more general implications and consequences of feminization with regard to social and gender history.
Provider: - Institution: - Data provided by Europeana Collections- Zita Gaier, Gedion Oduor Wekesa in "Sunburned" (2019)- Zita Gaier, Gedion Oduor Wekesa in "Sunburned" (2019)- All metadata published ...by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- Gedion Oduor Wekesa, Zita Gaier in "Sunburned" (2019)- Gedion Oduor Wekesa, Zita Gaier in "Sunburned" (2019)- All metadata published ...by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
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