As the lipidomics field continues to advance, self-evaluation within the community is critical. Here, we performed an interlaboratory comparison exercise for lipidomics using Standard Reference ...Material (SRM) 1950–Metabolites in Frozen Human Plasma, a commercially available reference material. The interlaboratory study comprised 31 diverse laboratories, with each laboratory using a different lipidomics workflow. A total of 1,527 unique lipids were measured across all laboratories and consensus location estimates and associated uncertainties were determined for 339 of these lipids measured at the sum composition level by five or more participating laboratories. These evaluated lipids detected in SRM 1950 serve as community-wide benchmarks for intra- and interlaboratory quality control and method validation. These analyses were performed using nonstandardized laboratory-independent workflows. The consensus locations were also compared with a previous examination of SRM 1950 by the LIPID MAPS consortium. While the central theme of the interlaboratory study was to provide values to help harmonize lipids, lipid mediators, and precursor measurements across the community, it was also initiated to stimulate a discussion regarding areas in need of improvement.
My Neighbor Totoro is a long-standing international icon of Japanese pop culture that grew out of the partnership between the legendary animator Miyazaki Hayao and the world-renowned composer Joe ...Hisaishi. A crucial step in the two artists' collaboration was the creation of the album, My Neighbor Totoro: Image Song Collection, with lyrics penned by Miyazaki and Nakagawa Rieko, a famed children's book author, and music composed by Hisaishi. The album, released in 1987 prior to the opening of the film, served not only as a promotional product, but also provided Miyazaki with concrete ideas about the characters and the themes of the film. This book investigates the extent to which Hisaishi's music shaped Miyazaki's vision by examining the relationship between the images created by Miyazaki and the music composed by Hisaishi, with special emphasis on their approaches to nostalgia, one of the central themes of the film.
Dieses Buch würdigt Robert Schuman (1886-1963), den fast vergessenen „Vater Europas“. Nach dem Zweiten Weltkrieg kämpfte er für eine europäische Zukunft ohne Krieg, Hass, Flucht und Armut.
Als ...französischer Außenminister bereitete er den Weg zur Schaffung eines gemeinsamen europäischen Wirtschaftsraums. Als französischer Ministerpräsident und Präsident des Europäischen Parlaments war er einer der Mitbegründer der Europäischen Union. In Luxemburg geboren und in Lothringen beheimatet, galt Schumans besonderer Einsatz der deutsch-französischen Versöhnung und der internationalen Jugendarbeit, stets getragen von seinem tiefen katholischen Glauben.
Manfred Kontz hat erstmals Zeitzeugenberichte und Zeitzeugnisse zum Leben Robert Schumans in einer dokumentarischen Biografie zusammengetragen. Es gilt, einen europäischen Politiker wiederzuentdecken, dessen Handeln im Einklang mit seinen Werten stand, der Versöhnung und Verständnis statt Spaltung und Polemik suchte.
In one of the most important publications on the European Convention and Court of Human Rights in recent years, a wide range of fundamental practical and theoretical problems of crucial importance ...are addressed in an original and critical way bringing a fresh, coherent and innovative order into well-known battle zones. The analysis revolves around the Court's fair balance-test and comprises in-depth analyses of e.g. methods of interpretation, proportionality, the least onerous means-test, the notion of absolute rights, subsidiarity, formal and substantive principles, evidentiary standards, proceduralisation of substantive rights etc. The author coins the term of "primarity" in order to clarify the obligation of the Contracting Parties to implement the Convention in domestic law.
Planning Labour: Time and the Foundations of Industrial Socialism in Romania. By Alina-Sandra Cucu. International Studies in Social History 32. New York, Oxford: Berghahn Books, 2019. 266 pp.
The existence of postinfection irritable bowel syndrome (PI-IBS) has been substantiated by epidemiology studies conducted in diverse geographic and clinical settings. However, the available evidence ...has not been well summarized, and there is little guidance for diagnosis and treatment of PI-IBS. The ROME Foundation has produced a working team report to summarize the available evidence on the pathophysiology of PI-IBS and provide guidance for diagnosis and treatment, based on findings reported in the literature and clinical experience.
The working team conducted an evidence-based review of publication databases for articles describing the clinical features (diagnosis), pathophysiology (intestinal sensorimotor function, microbiota, immune dysregulation, barrier dysfunction, enteroendocrine pathways, and genetics), and animal models of PI-IBS. We used a Delphi-based consensus system to create guidelines for management of PI-IBS and a developed treatment algorithm based on published findings and experiences of team members.
PI-IBS develops in about 10% of patients with infectious enteritis. Risk factors include female sex, younger age, psychological distress during or before acute gastroenteritis, and severity of the acute episode. The pathogenesis of PI-PBS appears to involve changes in the intestinal microbiome as well as epithelial, serotonergic, and immune system factors. However, these mechanisms are incompletely understood. There are no evidence-based, effective pharmacologic strategies for treatment of PI-IBS. We provide a consensus-based treatment algorithm, based on clinical presentation and potential disease mechanisms.
Based on a systematic review of the literature and team experience, we summarize the clinical features, pathophysiology (from animal models and human studies), and progression of PI-IBS. Based on these findings, we present an algorithm for diagnosis and treatment of PI-IBS based on team consensus. We also propose areas for future investigation.
Abstract
This article suggests that themes in Williams’ (2023) analysis of attention and contemplation resonate powerfully with current thinking in cognitive science. By changing how we pay ...attention, we can change the shape, or underlying configuration, of the heart‐mind. This is the core process in mindfulness and contemplation. The Interacting Cognitive Subsystems (ICS) analysis suggests this involves a shift in the balance between conceptual knowing and holistic‐intuitive knowing.
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