In this book, the author presents an interpretation of four thinkers: Nietzsche, Heidegger, Foucault, and Derrida. In an attempt to place these thinkers within the wider context of the ...crisis-oriented modernism and postmodernism that have been the source of much of what is most original and creative in twentieth-century art and thought.
This book examines the protection against refoulement under the European Convention on Human Rights and the UN Convention against Torture. It provides a comprehensive and comparative analysis of the ...non-refoulement case-law of both the European Court of Human Rights and the UN Committee against Torture.
O presente artigo apresenta uma contextualização do cenário brasileiro de 2020, em meio a mais grave pandemia dos últimos 100 anos, à luz da obra distópica 1984 de George Orwell, ficção sobre um ...futuro totalitário e opressor, publicada em 1949. Buscou-se elencar elementos da obra que apontam similaridades com o caso brasileiro, como a evocação de uma narrativa de ódio a opositores, gestão executiva destoando de sua missão institucional, uso deliberado de inverdades colocadas a público. As peças de acusação Dois Minutos de Ódio; Os Anti-ministérios e o Falseamento da verdade, extraídas de 1984, buscam expor tais similaridades.
In 2014, 30 years after the anti-Sikh pogrom (Chauraasi) instigated by the Hindu Right destroyed Sikh lives in New Delhi, I listened to the survivors and witnesses of the 1984 pogrom chat casually ...about their memories of the violence. Several visited their former homes at the original site of the violence and undertook 'walks' to remember what they had experienced. As they did so, they talked, creating a record of where their autobiographical re-tellings of those events created communal memory. While sociological scholarship attends to the trauma of 1984 (Saluja 2015; Das 2006), there is yet to emerge a reckoning with the performance iterations of such event-narratives as the memory walks. Using frameworks of witnessing, describing, and walking, thinking with how a walk can 'hear-tell' memory, I ask in this article: how does one re-tell testimonies of trauma and rumour that the survivors of Chauraasi remembered to and with a non-survivor? In what ways does rumour operate officially and informally? How does the telling, description, and undertaking of the memory walk reproduce a crisis of witnessing, and how does the aural and embodied performance of the walk respond to this crisis? How does the aporia between the descriptions emerging on memory walks and the ineffability of traumatic memory conjure the epistemic limits of narration?
The diagnosis of Alzheimer's disease can be improved by the use of biological measures. Biomarkers of functional impairment, neuronal loss, and protein deposition that can be assessed by neuroimaging ...(ie, MRI and PET) or CSF analysis are increasingly being used to diagnose Alzheimer's disease in research studies and specialist clinical settings. However, the validation of the clinical usefulness of these biomarkers is incomplete, and that is hampering reimbursement for these tests by health insurance providers, their widespread clinical implementation, and improvements in quality of health care. We have developed a strategic five-phase roadmap to foster the clinical validation of biomarkers in Alzheimer's disease, adapted from the approach for cancer biomarkers. Sufficient evidence of analytical validity (phase 1 of a structured framework adapted from oncology) is available for all biomarkers, but their clinical validity (phases 2 and 3) and clinical utility (phases 4 and 5) are incomplete. To complete these phases, research priorities include the standardisation of the readout of these assays and thresholds for normality, the evaluation of their performance in detecting early disease, the development of diagnostic algorithms comprising combinations of biomarkers, and the development of clinical guidelines for the use of biomarkers in qualified memory clinics.
O presente artigo se propõe a analisar a constituição e estrutura da Autoridade Nacional de Proteção de Dados a fim de discutir os riscos da interferência política na atuação da ANPD brasileira, em ...meio ao contexto de vigilância na sociedade de informação e em paralelo com a obra literária 1984, de George Orwell. Utilizando esse horizonte distópico como pano de fundo para demonstrar o impacto da atuação política do Estado no exercício da vigilância, recorreu-se a uma abordagem qualitativa, elaborada a partir de pesquisa bibliográfica e documental, para, ao final, concluir que, a ingerência política permitida pela estrutura institucional da ANPD brasileira é prejudicial à sua autonomia funcional, comprometendo a eficácia da Lei Geral de Proteção de Dados e possibilitando a existência de uma sociedade vigiada, comparável à narrativa distópica em cotejo.
We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and ...cerebrospinal fluid tau on disease duration.
We performed multistate modeling in a combined sample of 6 cohorts (n = 3268) with death as the end stage and estimated the preclinical, prodromal, and dementia stage duration.
The overall AD duration varied between 24 years (age 60) and 15 years (age 80). For individuals presenting with preclinical AD, age 70, the estimated preclinical AD duration was 10 years, prodromal AD 4 years, and dementia 6 years. Male sex, clinical setting, APOE ε4 allele carriership, and abnormal cerebrospinal fluid tau were associated with a shorter duration, and these effects depended on disease stage.
Estimates of AD disease duration become more accurate if age, sex, setting, APOE, and cerebrospinal fluid tau are taken into account. This will be relevant for clinical practice and trial design.
•First age-specific estimates of the duration of AD, including predementia stages.•Overall AD duration ranged from 24 years at age 60 to 15 years at age 80.•Preclinical AD stage was much shorter in a clinical setting than a research setting.•Females had a longer dementia duration.•APOE ɛ4 and CSF tau abnormality shortened the preclinical and prodromal AD stages.
The gut microbiota has emerged as an environmental factor that modulates the host's energy balance. It increases the host's ability to harvest energy from the digested food, and produces metabolites ...and microbial products such as short-chain fatty acids, secondary bile acids, and lipopolysaccharides. These metabolites and microbial products act as signaling molecules that modulate appetite, gut motility, energy uptake and storage, and energy expenditure. Several findings suggest that the gut microbiota can affect the development of obesity. Germ-free mice are leaner than conventionally raised mice and they are protected against diet-induced obesity. Furthermore, obese humans and rodents have an altered gut microbiota composition with less phylogeneic diversity compared to lean controls, and transplantation of the gut microbiota from obese subjects to germ-free mice can transfer the obese phenotype. Taken together, these findings indicate a role for the gut microbiota in obesity and suggest that the gut microbiota could be targeted to improve metabolic diseases like obesity. This review focuses on the role of the gut microbiota in energy balance regulation and its potential role in obesity.
Given its multifaceted relevance, Orwell’s 1984 has enjoyed a plethora of theoretical and artistic interpretations. However, I have not come across any such interpretation concerned with the ...ontological temporality of the novel, i.e. not its narrative development, but its use of temporality as the basic horizon of self-awareness, both existentially and politically. Considering this to be a key feature of both Orwell’s novel and totalitarian systems in general, I have taken upon myself the task of loosely exploring such an approach. As it will become apparent, I rely strongly on Heidegger’s account of existential and historical time (especially his concept of Being—towards-death). Basically, I will try to provide an existential account of totalitarianism as the resulting systemic product of the flight from the Beingtowards-death in particular, respectively an attempt at subduing temporality, in general. In addition, I will make, when deemed necessary, several contextual references to other thinkers such as Foucault, Nietzsche, Freud, Plato and Gadamer.
PDF
