Tremor is a common side effect of treatment with lithium. Its characteristics can vary and when less rhythmical, distinction from myoclonus can be difficult.
We identified 8 patients on long-term ...treatment with lithium that developed upper limb tremor. All patients were assessed clinically and electrophysiologically, with jerk-locked averaging (JLA) and cross-correlation (CC) analysis, and five of them underwent brain MRI examination including spectroscopy (MRS) of the cerebellum.
Seven patients (6 female) had action and postural myoclonus and one a regular postural and kinetic tremor that persisted at rest. Mean age at presentation was 58 years (range 42-77) after lengthy exposure to lithium (range 7-40 years). During routine monitoring all patients had lithium levels within the recommended therapeutic range (0.4-1 mmol/l). There was clinical and/or radiological evidence (on cerebellar MRS) of cerebellar dysfunction in 6 patients. JLA and/or CC suggested a cortical generator of the myoclonus in seven patients. All seven were on antidepressants and three additionally on neuroleptics, four of them had gluten sensitivity and two reported alcohol abuse.
A synergistic effect of different factors appears to be contributing to the development of cortical myoclonus after chronic exposure to lithium. We hypothesise that the cerebellum is involved in the generation of cortical myoclonus in these cases and factors aetiologically linked to cerebellar pathology like gluten sensitivity and alcohol abuse may play a role in the development of myoclonus. Despite the very limited evidence in the literature, lithium induced cortical myoclonus may not be so rare.
The biogeographic pattern of chloroplast DNA (cpDNA) haplotypes in Eucalyptus on the island of Tasmania is consistent with reticulate evolution, involving at least 12 Tasmanian species from the ...subgenus Symphyomyrtus. Intraspecific cpDNA polymorphism in 14 of 17 species is coupled with extensive sharing of identical haplotypes across populations of different species in the same geographic area. Haplotype diversity is lowest in central regions of Tasmania formerly occupied by alpine vegetation during glacial intervals and in northern regions that were periodically linked to continental Australia by land bridges. The observed distribution of several cpDNA haplotypes unique to Tasmania coincides with modeled locations of glacial refugia in coastal areas of Tasmania and shows the power of cpDNA in unraveling the complex history of past distributions of Eucalyptus. The results suggest that the model of evolution of the eucalypts should be reassessed to allow for the anastomosing effects of interspecific hybridization and introgression. Corresponding Editor: O. Savolainen
La enfermedad celiaca es un síndrome de malabsorción caracterizado por intolerancia a las proteínas del gluten en individuos genéticamente predispuestos con los alelos HLA-DQ2/DQ8. Su causa es ...multifactorial y los factores dietéticos, ambientales y genéticos tienen una significación importante en su aparición. El diagnóstico temprano posibilita prevenir complicaciones como la osteopenia, las enfermedades malignas y la infertilidad. El objetivo de este estudio fue compilar información actualizada sobre la base genética de esta enfermedad y su papel en el diagnóstico.The celiac disease is syndrome of malabsorption characterized by intolerance fo gluten proteins in subjects with genetic predisposition with the HLA-DQ2/DQ8 alleles. Its cause is multifactor and the dietetic, environmental and genetic factors have a great significance in its appearance. The early diagnosis allows the prevention of complications including osteopenia, malignant diseases and infertility. The aim of present paper was to collect updated information on the genetic base of this disease and its role in the diagnosis.
La enfermedad celiaca es un síndrome de malabsorción caracterizado por intolerancia a las proteínas del gluten en individuos genéticamente predispuestos con los alelos HLA-DQ2/DQ8. Su causa es ...multifactorial y los factores dietéticos, ambientales y genéticos tienen una significación importante en su aparición. El diagnóstico temprano posibilita prevenir complicaciones como la osteopenia, las enfermedades malignas y la infertilidad. El objetivo de este estudio fue compilar información actualizada sobre la base genética de esta enfermedad y su papel en el diagnóstico.
The objective of this study was to demonstrate the bactericidal, fungicidal, and sporicidal efficacy of the in-use concentration of ozone in solution generated continuously by the JLA Limited OTEX ...validated ozone laundering system against a range of typical microorganisms associated with laundering applications. The study used the JLA HC 100 laundering machine as the containment vessel. Test microbial suspensions were introduced directly into the drum of the laundering machine containing a known level of water in the presence of soluble ozone. Using standard microbiological techniques, the numbers of surviving bacteria, mold spores or bacterial spores were determined, and reductions in viable counts were calculated. The following test organisms were employed: Pseudomonas aeruginosa, Methicillin-Resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, E. coli, Acinetobacter baumannii, Aspergillus niger (spores), and Clostridium difficile (spores). All tests used multiple contact times of 0, 1, 3, 5, 7, 11 and 15 minutes at 20 °C±2 °C. Levels of ≤0.25 mg/L of dissolved ozone had minimal effect on the bacteria. Levels of >0.45 mg/L ozone showed good biocidal activity, except against Acinetobacter baumannii, which showed strong resistance to ozone. Against fungal spores, dissolved ozone levels of >1.2 mg/L were required to obtain a 2.8 log reduction. For Clostridium difficile spores, a dissolved ozone level between 0.90 and 1.20 mg/L gave >1.6 log reduction with no discernable spore recovery. In every instance, the control tests (no ozone) recovered levels of microorganisms that proved that the action of the laundering machine has no antimicrobial activity, and that the log reductions obtained are solely due to the effects of dissolved ozone.
"Cabrera JLA obtuvo premios en congresos internacionales por el desarrollo de nuevos metodos utilizando tecnologia de la mas avanzada en el mundo", asegura Roberto Sandrini, titular de la firma. En ...2011, Argentina exporto 530 mil toneladas de mani, generando ingresos por 743 millones de dolares, a lo que se suman mas de 60 mil toneladas de productos derivados como pasta de mani, manteca, aceite, harina y pellets. "En los ultimos anos, la globalizacion hizo que los compradores se acerquen a los vendedores y le compren directamente, eludiendo a los brokers. Esto requiere que el comprador este seguro de la calidad; pero aun cuando el producto sea bueno, a veces no alcanza, hay que demostrarlo y certificarlo", advierte Sandrini. (c) 2012 NoticiasFinancieras - La Voz del Interior - All rights reserved
This paper describes a cooperative research project by the Japan Library Association (JLA) and the National Diet Library (NDL) to create Linked Data for the Nippon Decimal Classification (NDC). The ...NDC is a Japanese standard classification system that is edited and published by the JLA. This project was carried out from April 2015 to March 2016, during which time the 8th and 9th editions of the NDC were converted on a trial basis from Machine Readable Data Format (MRDF) to the Linked Data format. The authors first established a conversion policy based on the anticipated needs of patrons to utilize the data in an information system and then developed a hierarchical structure model for NDC classes, a metadata schema for NDC semantics, and a label with contexts. In addition, the authors also synthesized the classes with auxiliary tables and generated classes automatically from a relative index and other resources. NDC Linked Data also references National Diet Library Subject Headings as external data. After evaluating the outcome of this project, the JLA will conduct further research into the provision and use of NDC Linked Data.
To characterize juvenile idiopathic arthritis (JIA) patients from multicase families.
The study series comprised 80 affected siblings belonging to 37 families. Comparisons were made with a ...population-based series of JIA patients from Finland and with a sibling series from the United States.
The distribution of cases according to onset type was similar in the sibling and population-based series. The age at diagnosis was significantly lower in the sibling series (4.8 years vs 7.4 years; p < 0.001). There was more intra-pair similarity in onset and course types in the United States series compared to the Finnish series and the proportion of girls was higher in the former.
The only significant difference between familial and sporadic cases with JIA is an earlier onset of disease in familial cases. There is no essential difference in clinical features of the disease between patients in the multicase and sporadic groups. Differences between the Finnish and US series may be due to selection bias in the latter.
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