Centrifugal pumps operated in reverse mode (popularly called pump as turbines (PATs)) are well-established as green energy converters, mainly used in microhydro applications due to their lower ...capital cost. However, the appropriate selection of the pump for reverse-mode application is a critical issue due to the unavailability of its characteristic curve in turbine mode. Therefore, various researchers have proposed models to predict PAT parameters from pump characteristics based on diverse approaches. Still, researchers are striving to develop a prediction model, which can predict the head and flow rates for the PAT with less than ±20 % deviation for both. This work proposed a novel approach to predict the characteristics of PAT with the integration of ensemble regression modelling for Best Efficiency Point (BEP) and from it, by polynomial equations complete characteristics curve. The data from in-house experiments and open literature are used to develop the proposed model excluding the data of four pumps, which are typically used for validation of it. The predicted parameters of PAT from pump characteristics show good agreement for four selected PATs with <10 % maximum deviation. Compared to the literature prediction models, it shows a lower deviation for the same four PATs. A case study based on the field data is carried out to justify the applicability of the proposed model. By using this model selected pump when operated in PAT will produce higher power and generate more revenue compared to literature models, resulting in the economical utilization of resources and improving sustainability. Though the savings are lower, it will be significant for a large number of PAT applications.
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•Performed experimental investigation of 43.7 rpm PAT on in-house test facility.•Developed a novel prediction model for complete characteristics based on machine learning ensemble regression model of PAT.•Proposed model tested on a wide range of PAT from low to medium specific speed with ±20 % maximum deviation.•Comparison with literature models shows superior results of the proposed model.•The proposed model-based case study shows higher power and revenue than literature, indicating an improved sustainability.
CsxWO3 nanorods coated with polyelectrolyte multilayers are developed as “four‐in‐one” multifunctional nanomaterials with significant potential for computed tomography/photoacoustic tomography ...bimodal imaging‐guided photothermal/photodynamic cancer treatment.
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•A DNA walking machine-based labeled aptasensor is developed.•Ultrasensitive detection of Patulin by reliable electrochemical.•Zr-MOFs load with a large number of methylene blue ...probes.•Pt@AuNRs/Fe-MOFs/PEI-rGO facilitate signal amplification.•The sensor exhibits high specificity and satisfactory long-term stability.
A Nb.BbvCI powered DNA walking machine as signal enhancer, gold-platinum core-shell nanorods/iron-based metal-organic frameworks/polyethyleneimine-reduced graphene oxide composites (Pt@AuNRs/Fe-MOFs/PEI-rGO) as electrode modification material and Zr-based metal-organic frameworks-labeled oligonucleotides load with methylene blue (MB@Zr-MOFs-cDNA) as signal probes has been fabricated to obtain a sensitive electrochemical aptasensor for patulin (PAT) detection. In the DNA walking machine, PAT takes the aptamer away from the DNA walking chain (wDNA), and wDNA can repeatedly dissociate the MB@Zr-MOFs-cDNA under the Nb.BbvCI power to amplify the detection signal. In addition, Pt@AuNRs/Fe-MOFs/PEI-rGO modified gold electrode provides high stability (60 scans without significant change), catalytic performance (compared to bare gold electrode signal enhancement 250%), and high conductivity (calculated apparent electron transfer rate constant is 1.64 s−1). With such design, the as- prepared aptasensor exhibits good sensitivity from 5.0 × 10−5 ng·mL−1 to 5.0 × 10−1 ng·mL−1 with a detection limit of 4.14 × 10−5 ng·mL−1. This aptasensor construction mode can supply one efficient approach to improve signal amplification, which also open an avenue for sensitivity enhancement in detection of analytes.
The energy efficiency of water supply systems is usually very low. They are affected by a high rate of water leakage with a significant loss in terms of the energy that is embedded in the lost water ...flow. Furthermore, the strategy to reduce the water loss frequently involves pressure reduction with a further decrease in energy efficiency. Several solutions have been proposed in the literature to reduce the pressure in the water distribution networks and recover the hydraulic energy, such as special turbines or pumps as turbines (PATs). Despite the positive aspects related to the use of such devices, the high installation costs, together with the limited hydraulic control capacity and the small power availability, limited the diffusion of such devices among the water utilities. A new device is proposed herein, which consists of two submersible PATs inserted into a booster cylinder. The high control capacity, together with the small production and installation costs, makes this technology very promising. The device has been installed in the Hydro Energy Lab of the CeSMA of the University of Naples and the first experimental results on its behavior are presented herein. A slight difference arises between the performance booster curves and the bare curves provided by the manufacturer due to measurement errors as well as to the presence of head loss within the system. Nevertheless, the energy efficiency of the plant results will be preserved, making this design a promising solution to overcome most of the limitations of the present technologies when low energy is available and large discharge variation occurs.
•A review of pharmaceutical utilization of machine vision.•A brief introduction to machine vision and digital image analysis is given.•PSD measurements during crystallization, granulation, fluid bed ...coating.•Analysis of properties of tablet cores and film coated tablets.•RTD measurements using colored tracer materials.
The goal of this paper is to give an introduction to analysis of images acquired by a digital camera with visible illumination and to review its applications as a Process Analytical Technology (PAT) which has great potential in pharmaceutical manufacturing. By utilizing in-line analytical techniques, it is possible to monitor the quality of all the material leaving a processing unit and to create models capable to predict product quality attributes, which are otherwise measured by cumbersome off-line techniques. The rapidly developing machine vision has proven its versatility in numerous applications and it has great potential as an in-line analytical tool. The ongoing conversion of the pharmaceutical industry from batch to continuous manufacturing accelerated the development of digital image analysis methods in the last decade. Among numerous other benefits, continuous technologies, equipped with digital image analysis, enable detecting disturbances in the material flow, and analyzing the products comprehensively. The purpose of this work is to give an insight into the currently available image analysis methods in the characterization of powders, crystallization, granulation, milling, mixing, tableting, film coating, in vitro dissolution testing, and residence time distribution measurements by highlighting some of the most relevant examples of application.
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Lethal small molecules are useful probes to discover and characterize novel cell death pathways and biochemical mechanisms. Here we report that the synthetic oxime-containing small molecule ...caspase-independent lethal 56 (CIL56) induces an unconventional form of nonapoptotic cell death distinct from necroptosis, ferroptosis, and other pathways. CIL56-induced cell death requires a catalytically active protein S-acyltransferase complex comprising the enzyme ZDHHC5 and an accessory subunit GOLGA7. The ZDHHC5-GOLGA7 complex is mutually stabilizing and localizes to the plasma membrane. CIL56 inhibits anterograde protein transport from the Golgi apparatus, which may be lethal in the context of ongoing ZDHHC5-GOLGA7 complex-dependent retrograde protein trafficking from the plasma membrane to internal sites. Other oxime-containing small molecules, structurally distinct from CIL56, may trigger cell death through the same pathway. These results define an unconventional form of nonapoptotic cell death regulated by protein S-acylation.
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•CIL56 triggers an unconventional form of nonapoptotic cell death•Cell death requires protein acylation by a ZDHHC5-GOLGA7 complex•CIL56 alters the structure of the Golgi apparatus and other organelles•CIL56 and the ZDHHC5-GOLGA7 complex regulate membrane trafficking
CIL56 is a synthetic oxime that can trigger a form of nonapoptotic cell death that is distinct from apoptosis, necroptosis, ferroptosis, and classic necrosis. This unconventional form of cell death is promoted by a plasma membrane protein acyltransferase complex comprising ZDHHC5 and GOLGA7.
This article is concerned with the problem of fixed-time (FXT) and preassigned-time (PAT) synchronization for discontinuous dynamic networks by improving FXT stability and developing simple control ...schemes. First, some more relaxed conditions for FXT stability are established and several more accurate estimates for the settling time (ST) are obtained by means of some special functions. Based on the improved FXT stability, FXT synchronization for discontinuous networks is discussed by designing a simple controller without a linear feedback term. Besides, the PAT synchronization is also explored by developing several nontrivial control protocols with finite control gains, where the synchronized time can be prespecified according to actual needs and is irrelevant with any initial value and any parameter. Finally, the improved FXT stability and the synchronization for complex networks are confirmed by two numerical examples.
Soy el Hijo del Sol Cristobal Pat Chable, Jesus
Maya America,
02/2021, Letnik:
3, Številka:
1
Journal Article
Recenzirano
Odprti dostop
En 2009 inicio su carrera de rapero como solista, promoviendo su primer rap en lengua maya. Eligió su nombre artístico Pat Boy, ya que “Pat” significa darle forma a algo o crear algo nuevo, una ...palabra en la lengua de sus ancestros mayas (como Jacinto Pat) que fueron luchadores de a guerra social maya. Su trabajo se enfoca en el fortalecimiento de la lengua maya y con sus canciones la difunde más allá de las fronteras para los jóvenes y personas de todas las edades. Si objetivo es llegar a nuevos horizontes, marcando su propio estilo. Sus temas hablan sobre la vida cotidiana de un maya: tradiciones, costumbres, educación, el amor, reflexiones de la vida y la lucha social. Fusiona su Rap con otros géneros musicales como el Reggae, Pop, y Reggaetón.
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