Drawing upon conservation of resources theory, we develop and test a theoretical model that specifies how and when employee humor toward leaders affects leader abusive supervision. We propose that ...employee humor is negatively associated with leader abusive supervision via leader relational energy. Furthermore, the negative indirect relationship between employee humor and leader abusive supervision via leader relational energy is stronger for female leaders than for male leaders. An experiment and a multi-wave, multi-source field study provide substantial support for our hypotheses. Our findings contribute to the abusive supervision literature by identifying employee humor as a safe and effective bottom-up approach to prevent leader abusive supervision.
Each day for two weeks participants described how often they had used four types of humor that day: affiliative, self-enhancing, aggressive, and self-defeating humor. Each day, participants also ...described the events that occurred in their lives (positive and negative crossed with social and achievement), and they provided measures of their well-being. Multilevel analyses (days nested within persons) found that the daily use of affiliative and self-enhancing humor was positively related to daily positive events (social and achievement) and was negatively related to daily negative events (social and achievement). In contrast, the use of self-defeating humor was positively related to the occurrence of all types of events. Affiliative and self-enhancing humor was positively related to positively valent measures of well-being (e.g., self-esteem), and were negatively related to negatively valent measures of well-being (e.g., rumination). In contrast, relationships between well-being and the use of self-defeating humor were the mirror image of these relationships. The use of aggressive humor was unrelated to well-being. These results suggest that the use of humor is cued by the events that occur in people’s daily lives, social and achievement and good and bad, and that the use of humor is related to well-being, both positively and negatively.
This qualitative study aims to investigate the competencies and effectiveness of humor use in workplace leadership. By exploring the elements underlying successful and unsuccessful humor use, this ...research offers insights into the competencies required for leaders to leverage humor effectively. Adopting a qualitative inductive approach, fifteen individual semi-structured interviews were conducted, generating a dataset of 51 critical incidents of humor use. Reflexive thematic analysis was employed to identify key themes, resulting in the identification of five central elements: Reading the context, Intention and motivation, Judgement and decision, Skillful delivery, and Understanding reactions. These elements provide a comprehensive framework for understanding humor use in the context of workplace leadership, emphasizing the importance of cognitive and emotional intelligence / competencies. The study proposes a theoretical framework based on these findings, providing the foundation of a new paradigm for understanding and measuring humor use. This research contributes to a deeper understanding of the competencies and complexities involved in using humor as a leadership tool and provides practical implications for leaders aiming to enhance their leadership effectiveness through humor.
Glaucoma is one of the major causes of blindness, affecting together with age-related macular degeneration > 70 million people worldwide. One of the therapeutic options for its management is based on ...the inhibition of the metalloenyme carbonic anhydrase (CA, EC 4.2.1.1). CA inhibitors (CAIs) diminish intraocular pressure (IOP) by reducing the rate of bicarbonate formation and thus secretion of the aqueous humor.
The main classes of clinically used antiglaucoma CAIs are the sulfonamides with systemic (acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide) and topical (dorzolamide and brinzolamide) action. A patent literature review covering the period 2007 - 2013 is presented.
This review presents an overview of the patent literature in the CAI antiglaucoma drug design field during the past 6 years. Most of the patents deal with sulfonamide/sulfamide/sulfamate CAIs, sulfonamides incorporating NO-donating moieties, as well as hybrids incorporating sulfonamide and prostaglandin (PG) analogs, were also reported. There is an urgent need for new antiglaucoma CAIs/approaches to treat and diagnose this disease in the very near future, as the last drug which has been discovered in the field (latanoprost) dates back > 10 years ago.
The present study empirically tests a bimodal model of humor appreciation. In this model, individual differences in evaluating jokes and cartoons are attributed to their contents (sexual and ...aggressive) and structures (incongruity-resolution and nonsense). A total of 225 participants (64% women, Mage = 32.37 years) rated 50 jokes and cartoons on funniness, offensiveness, and boringness. They also completed a standard humor appreciation measure (the 3 WD). Using structural equation modeling, the bimodal model was found to be superior to alternative models. Regressions predicting the 3 WD categories supported the convergent and discriminant validity of the content and structure factors. In line with previous research, gender differences were found for the content factors, but not for the structure factors. Overall, this study is the first to show the viability of bimodal models of humor appreciation. They allow capturing the sources of individual differences in humor appreciation more adequately than previous models, thus providing a basis for future theories, research, and applications.
This book addresses the fact that Americans tend to live under a considerable amount of stress, tension, and anxiety, and suggests that humor can be helpful in alleviating their distress. It posits ...that humor is a useful placebo in this regard; cites studies that show that humor moderates life stress; considers the relationship of religion and humor, especially as means to alleviate anxiety; proposes that Jesus had a sense of humor; suggests that his parable of the Laborers in the Vineyard has humorous implications for the relief of occupational stress; explores the relationship of gossip and humor; and suggests that Jesus and his disciples were a joking community. It concludes that Jesus viewed the kingdom of God as a worry-free existence.
Laughter is the best medicine Slop, FRCS
Bulletin of the Royal College of Surgeons of England,
03/2021, Letnik:
103, Številka:
2
Journal Article
Odprti dostop
Messages urging him to invest in bitcoins as well as deals on life insurance and Ryanair flights almost submerged the nondescript note from The Bulletin’s chief honcho. Perhaps some of the research ...he had dug up for his talk on The History of Humour in Medicine might interest his readers? Josh Case. https://joshcase.dev/articles/reasons-doctors-and-medical-students-should-learn-to-code (cited February 2021).
Trabecular meshwork (TM) pigmentation is not correlated with angiographically determined aqueous humor outflow (AHO) in an ex vivo perfusion model using human eyes.
To evaluate whether segmental TM ...pigmentation is correlated to segmental AHO in human eyes.
Postmortem human eyes were acquired, and anterior segments were dissected. TM pigmentation was photographed 360-degrees around the eye. The anterior segments were then mounted onto a perfusion apparatus and perfused with Dulbecco's phosphate buffered saline (DPBS) until a stabile baseline outflow facility was achieved. Aqueous angiography (AHO angiography) was performed using fluorescein (2%), and segmental AHO was documented around the limbus using an angiographic camera (Spectralis HRA+OCT). Circumferential and nasal TM pigmentation were compared with respective angiographic outflow imaging using a Pearson correlation analysis.
Segmental TM pigment distribution and segmental AHO were seen. TM pigment was statistically greatest in the inferior quadrant. AHO angiographic outflow was numerically greatest in the nasal quadrant, but this was not statistically significant. No statistically significant correlation was observed (r=-0.083, P =0.06) between segmental TM pigmentation and segmental AHO angiographic signal. Analyzing just the nasal quadrant, a significant weak negative correlation was found (r=-0.296, P =0.001).
Segmental TM pigmentation circumferentially around the eye is not a good proxy for segmental AHO circumferentially around the eye and should not be used to guide trabecular minimally invasive glaucoma surgeries.
Corneal endothelial decompensation (CED) is the major cause of the long-term graft failure, but the underlying mechanisms remain unclear. The purpose of this study was to characterize the proteomic ...profile in CED aqueous humor (AH) after penetrating keratoplasty (PKP). We collected AH samples (n = 6/group) from CED patients underwent PKP and cataract patients, respectively. The label-free quantitative proteomic analysis was performed to identify the differentially-expressed proteins (DEPs). The biological functions of DEPs were evaluated using Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genome (KEGG) analysis. The protein-protein interaction (PPI) network construction was employed to distinguish the hub proteins of DEPs, and the selected proteins were validated by parallel reaction monitoring (PRM). The human peripheral blood mononuclear cells (PBMCs) were adopted to investigate the effect of biglycan (BGN) on inflammatory response, and the subsequent outcomes of inflammation on human corneal endothelial cells (HCECs). A total of 174 DEPs were identified in CED AH of patients underwent PKP, including 102 up-regulated proteins and 72 down-regulated proteins. Bioinformatics analysis revealed the significant enrichment of cytokine-mediated signaling pathway and extracellular matrix (ECM) organization in the up-regulated proteins, as well as the alterations of cellular components, including the increase of collagen and complement component C1 complex, and reduction in extracellular exosomes. A hub protein cluster of 15 proteins was determined by Molecular Complex Detection (MCODE), including FN1, BGN, COMP, COL11A1, COLA3A1, and COL1A1. Moreover, BGN promoted pro-inflammatory cytokine (such as TNF-α, IL-1β and IL-6) production in PBMCs through NF-κB signaling pathway, which subsequently resulted in HCECs death. These findings provided a systemic protein profile of AH in CED patients after corneal transplantation, with the alterations implicated in cytokine-mediated signaling, ECM, complement system, and exsomes. The identified proteins and signaling pathways probably paved the novel insight into understanding the pathogenesis of the disease.
•The protein profile of aqueous humor in CED was quite different from cataract group.•The up-regulated proteins are functionally associated with inflammatory response.•Atypical enrichment of ECM and C1 complex in the up-regulated proteins of CED.•The extrinsic component of (plasma) membrane, and exosomes were remarkably reduced.
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