If you have an employee who habitually has the Monday morning "flu" or one who works sporatic in spurts of activity that may last a day or one who takes long lunch hours, then you might have a ...problem. These could be "red flags" of warning of a potential chemical dependency -- alcohol or drug abuse. Gloria Heatherington, community relations director for the new Horizon Recovery Center at Raleigh Hills Hospital, said that there are behavior patterns that employers should not ignore. Raleigh Hills is Anchorage's newest alcohol and drug abuse treatment hospital. When it opened on Bragaw Street last week, it became the 19th in the Raleigh Hills chain. There are similar facilities in Oregon as well as other parts of the Lower 48. The treatment facility was begun in the early 1940s, the first of its type in the country. (excerpt)
Last summer, Mr NEMIR KIRDAR was revealed as the secretive millionaire businessman who played host to Prince Charles and Camilla Parker Bowles at his private hideaway on the French Riviera. His ...fondness for privacy has inspired a series of sensational, if inaccurate, stories over the years. One was that he escaped Iraq during the 1950s coup that toppled the country's ruling Hashemite royal family by wrapping himself in a Persian carpet. In the book-lined study of his Mayfair offices, Mr Kirdar says the road to Investcorp began in 1958. He was studying in Istanbul when he heard news that King Faysal had been deposed. Everyone expected the king to fly to Istanbul. Instead, he was executed. "I was at Istanbul airport, awaiting the arrival of King Faysal, whom I knew," he recalls, dispelling stories that he had fled during the uprising. "But, of course, the plane never came." Mr Kirdar left Chase and set up Investcorp in 1982. In the intervening years, the company has been associated with some glamorous names: Tiffany, Gucci and, of course, Saks. But the company has also invested in less familiar names: Burnham, a logistics company; CSK Auto, a car parts company; and Carvel, an ice cream manufacturer.
Last summer, Mr NEMIR KIRDAR was revealed as the secretive millionaire businessman who played host to Prince Charles and Camilla Parker Bowles at his private hideaway on the French Riviera. His ...fondness for privacy has inspired a series of sensational, if inaccurate, stories over the years. One was that he escaped Iraq during the 1950s coup that toppled the country's ruling Hashemite royal family by wrapping himself in a Persian carpet. In the book-lined study of his Mayfair offices, Mr Kirdar says the road to Investcorp began in 1958. He was studying in Istanbul when he heard news that King Faysal had been deposed. Everyone expected the king to fly to Istanbul. Instead, he was executed. "I was at Istanbul airport, awaiting the arrival of King Faysal, whom I knew," he recalls, dispelling stories that he had fled during the uprising. "But, of course, the plane never came." Mr Kirdar left Chase and set up Investcorp in 1982. In the intervening years, the company has been associated with some glamorous names: Tiffany, Gucci and, of course, Saks. But the company has also invested in less familiar names: Burnham, a logistics company; CSK Auto, a car parts company; and Carvel, an ice-cream manufacturer.
Investcorp is primarily a conduit of Middle Eastern money into Western deals. It has a roster of some 300 core investors, primarily Arab, who participate in its deals. Headquartered in Bahrain, but ...with most of the action coming from its London and New York offices, Investcorp is headed by Nemir Kirdar, a Fordham University MBA who was born in Iraq and learned deal-making at Chase Manhattan in the late 1970s. Kirdar looks for companies that are basically sound but need additional capital. After holding on to an investment, say for 5 years, but hopefully less, Investcorp takes the company public or sells it through a private placement. It then pays off its investors, keeps its share, and looks for another deal. Investcorp is owned 37.5% by management, 15% by the original investors, and the rest is traded on the Bahrain stock exchange. With his access to polls of Middle Eastern cash, Kirdar can easily swing big deals. He wrote a $1.6 billion check to buy Saks Fifth Avenue.
Les néoplasies endocriniennes multiples (NEM) sont des syndromes de prédisposition génétique aux tumeurs endocrines comprenant les NEM1, NEM2 et exceptionnellement les NEM4. Les NEM sont transmises ...par voie autosomique dominante avec une forte pénétrance. Une corrélation génotype/phénotype est classiquement retrouvée chez les patients ayant une NEM2 mais pas pour les NEM1. Les patients avec une NEM1, liée à une mutation inactivatrice du gène de la ménine, peuvent présenter : une hyperparathyroïdie primaire, un adénome hypophysaire, des tumeurs neuroendocrines (TNE) duodéno-pancréatiques et/ou bronchiques avec un surrisque de thymome, des tumeurs corticosurrénaliennes ; un sur-risque de cancer du sein et une atteinte cutanée caractéristique telle que les collagénomes, les lentiginomes et un sur-risque de cancer cutané. Ces patients nécessitent un suivi annuel au minimum. Le dépistage des enfants est proposé à partir de l’âge de 5 ans. Les patients avec une NEM2, liée à une mutation activatrice du proto-oncogène RET, présentent tous un carcinome médullaire thyroïdien (CMT) à un âge variable selon le génotype. Certains patients présentent un phéochromocytome (50 %) et une hyperparathyroïdie (20 %). Des formes pédiatriques avec un CMT agressif, une ganglioneuromatose et un syndrome marfanoïde existent (rare NEM2B). Certaines mutations sont associées à un risque de CMT agressif, justifiant une thyroïdectomie prophylactique avant l’âge de 6 mois. L’âge du dépistage génétique dépend du soustype de mutation chez le parent porteur de NEM2. Les NEM4, liées à une mutation du gène CDKN1B, sont rares, avec une pathogénie moins bien connue et leur suivi n’est pas bien codifié.
Multiple endocrine neoplasia (MEN) are genetic predisposition syndromes to endocrine tumors including MEN1, MEN2 and exceptionally MEN4. MEN are transmitted in an autosomal dominant fashion with a high penetrance. Classically, there is no genotype/phenotype correlation for NEM1 whereas this is the case for NEM2. Patients with NEM1, linked to an inactivating mutation of the menin gene, may present with: primary hyperparathyroidism, pituitary adenoma, duodeno-pancreatic neuroendocrine tumors (NETs), bronchial tumors with an increased risk of thymoma, adrenal cortical tumors, an increased risk of breast cancer and characteristic skin involvement such as collagenomas, lentiginomas and an increased risk of skin cancer. These patients require at least annual follow-up. Screening of children is proposed from the age of 5 years. Patients with NEM2, linked to an activating mutation of the RET proto-oncogene, all present with medullary thyroid carcinoma (MTC) at a variable age depending on the genotype. Some patients present a pheochromocytoma (50 %) and hyperparathyroidism (20 %). Pediatric forms with aggressive CMT, ganglioneuromatosis and marfanoid syndrome exist (rare NEM2B). Some mutations are associated with a risk of aggressive CMT, justifying prophylactic thyroidectomy before 6 months of age. The age of genetic testing depends on the mutation subtype in the NEM2 parent. NEM4, related to a mutation in the CDKN1B gene, are rare, with a less well-known pathogenesis and their follow-up is not well codified.
L’extrême sensibilité des résonateurs mécaniques (NEMS) aux variations physiques à l’échelle atomique a permis le développement d’un nouveau concept de spectrométrie de masse à base de NEMS capable ...de mesurer la taille d’une particule unique. L’utilisation de large réseau de capteurs doit permettre à terme de palier la faible surface de capture des résonateurs tout en ouvrant de nouvelles perspectives pour les applications qui nécessitent des informa- tions sur la répartions spatiale des particules au sein du faisceau de mesure. Pour réaliser un spectromètre de masse à base de NEMS viable pour des applications de mesures réelles, il est impératif de développer une technologie de co-intégration NEMS CMOS permettant de fortement densifier le niveau d’interconnexion entre le capteur et l’électronique de lecture. Dans ce travail, nous présentons les premiers résultats mettant en oeuvre une telle techno- logie au travers de mesures de laboratoire et de la conception de circuit intégré co-intégré avec les résonateurs mécaniques. L’électronique de lecture capable de suivre la fréquence de nombreux NEMS simultanément est encore un facteur limitant la forte intégration nécessaire à la lecture de grand réseau de NEMS (>1000), les travaux de cette thèse mettent l’accent sur les problématiques liées à la lecture d’un grand nombre de résonateurs en termes de surface de silicium, de consommation et de performances. Nous présentons dans ce manuscrit une nouvelle architecture d’oscillateur hétérodyne bimode qui doit permettre de répondre à la fois au besoin de compacité tout en assurant le suivi simultané des différents modes de résonances des capteurs. Les travaux présentent également l’effort de modélisation et de co-simulation électro mécanique mis en oeuvre pour la conception des trois circuits. Enfin, nous présentons les résultats de mesure physique obtenue avec l’un des circuits revenus de fabrication et testé au sein du banc de spectrométrie de masse mise en place par les équipes du CEA/LETI.
The extreme sensitivity of nano electro mechanical system (NEMS) to atomic scale physical variations has led to the breakthrough development of NEMS- based mass spectrometry sys- tems capable of measuring a single molecule. Parallel sensing using thousands of devices will help to circumvent the small effective sensing area while opening new perspectives for applica- tions which require spatial mapping. While the development of NEMS CMOS co-integration technology is of paramount importance to achieve high density sensor arrays (>1000 devices), the readout circuitry capable of tracking NEMS resonator frequency shifts is still the limiting factor for the very large scale integration of individually addressed sensors. Moreover, in order to resolve the mass and position of an adsorbed analyte, single particle mass sensing appli- cations require to track simultaneously and in real time at least two modes of the resonators. This requirement adds complexity to the design of the overall system. To respond to the size, power consumption and resolution constraints linked to NEMS array measurement, this work focuses on the development of a new readout architecture based upon a dual mode heterodyne oscillator. This work also emphasis the effort made on the modelization and co-simulation of the NEMS devices with their readout electronics. Then, the manuscript describe the first results of the CEA/LETI CMOS co-integraton process developed to tackle the sensor density challenge of mass spectrometry application. Finally, present the two integrated circuit that were designed during this thesis. The first one was a proof of concept for the aforementioned oscillator architecture while the second one combine the architecture with the co-integration processus developed.
Luisa Ricaldone présente une figure originale de femme écrivain antiféministe et catholique, Orsola Nemi, dont les convictions allèrent jusqu’à lui faire refuser un prix littéraire féminin qui lui ...était décerné. Après avoir présenté l’auteur et son œuvre, elle centre son propos sur un roman où s’exerce de façon caractéristique la veine polémique et sarcastique de l’écrivain. Il sarto stregato (1960) est en effet une féroce satire d’un certain type d’intellectuel, de la mode du roman réaliste et des critiques littéraires qui le soutiennent, et a pour but de discréditer la culture de gauche.
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