Osteoarthrosis of the knee is a degenerative disease with inflammatory episodes objectively shown by arthrosonography. Cartilage Oligomeric Matrix Protein - COMP is a useful biomarker for early ...cartilage destruction. The aim of this paper is a comparative analysis of the clinical, arthrosonographic findings and the COMP concentration in the sera of patients for the detection of joint inflammation. The analysis included 88 patients with knee OA. Clinical examination determined the outflow, arthrosonography the size of synovitis and effusion, and serum analysis the COMP concentration (ng/ml). Minimum outflow had 34.1% of patients, moderate 22.7%, and significant 4.5%. Sensitivity of the clinical diagnosis of outflow is 73%, and specificity 73% (p=0.000). Seventy five percent of patients had effusion; 28.4% of patients in the suprapatellar recessus (SR), 27.3% in the medial (MR), and 62.5% in the lateral (LR). In SR, effusion was 10.13±4.35 mm, MR 8.53±2.27 mm, LR 11.38±4.44 mm. Synovitis was found in 67% of patients, in SR the size of 4.84±3.57 mm, in MR 3.15±1.86 mm, in LR 6.09±2.80 mm. The average value of the size of effusion in patients with significant outflow in SR was 13.85 (10.36-17.43) mm (p=0.000), MR 4.9 (0-10.22) mm (p=0.008), LR 12.0 (11.34-14.50) mm (p=0.000), in LR with moderate outflow 6.94 (1.16-8.13) mm and minimum outflow 4.9 (0-7.25) mm. There is a significant correlation between the size of synovitis and effusion in the SR, MR and LR (p=0.000). The average value of the concentration of COMP in patients without effusion was 54 (44.5-58) ng/ml, with effusion 57 (48.75-64.25) ng/ml (p=0.030). Arthrosonography and the determination of the COMP concentration are sensitive methods for diagnosing joint effusion.
Osteoartroza (OA) kolena je degenerativna bolest sa inflamatornim epizodama koje artrosonografija objektivno prikazuje. Oligomerni protein matriksa hrskavice - COMP je korisan marker za ranu destrukciju hrskavice. Cilj rada je uporedna analiza kliničkog, artrosonografskog pregleda i koncentracije COMP u serumu bolesnika radi detekcije zglobne inflamacije. Analizom je obuhvaćeno 88 bolesnika sa OA kolena. Kliničkim pregledom je utvrđen izliv, artrosonografskim veličina sinovitisa i efuzije, analizom seruma koncentracija COMP (ng/ml). Minimalan izliv je imalo 34,1% bolesnika, umeren 22,7%, značajan 4,5%. Senzitivnost kliničke dijagnoze izliva je 73%, a specifičnost 73% (p=0,000). Efuziju je imalo 75% bolesnika, u suprapatelarnom recesusu (SR) efuziju je imalo 28,4% bolesnika, medijalnom (MR) 27,3%, lateralnom (LR) 62,5%. U SR efuzija je bila 10,13±4,35 mm, MR 8,53±2,27 mm, LR 11,38±4,44 mm. Sinovitis je nađen kod 67% bolesnika, u SR veličine 4,84±3,57 mm, MR 3,15±1,86 mm, LR 6,09±2,80 mm. Srednja vrednost veličine efuzije kod bolesnika sa značajnim izlivom u SR je bila 13,85 (10,36-17,43) mm (p=0,000), MR 4,9 (0-10,22) mm (p=0,008), LR 12,0 (11,34-14,50) mm (p=0,000), samo u LR sa umerenim izlivom 6,94 (1,16-8,13) mm i minimalnim izlivom 4,9 (0-7,25) mm. Postoji značajna povezanost veličine sinovitisa i efuzije u SR, MR i LR (p=0,000). Srednja vrednost koncentracije COMP kod bolesnika bez efuzije je bila 54 (44,5-58) ng/mL, sa efuzijom 57 (48,75-64,25) ng/mL (p=0,030). Artrosonografija i određivanje koncentracija COMP predstavljaju senzitivne metode u dijagnostikovanju zglobne efuzije.
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