The omics technologies have improved our understanding of the molecular events that underpin host-parasite interactions and the pathogenesis of parasitic diseases. In the last decade, proteomics and ...genomics in particular have been used to characterize the surface and secreted products of the carcinogenic liver fluke Opisthorchis viverrini and revealed important roles for proteins at the host-parasite interface to ensure that the flukes can migrate, feed and reproduce in a hostile environment. This review summarizes the advances made in this area, primarily focusing on discoveries enabled by the publication of the fluke secreted proteomes over the last decade. Protein families that will be covered include proteases, antioxidants, oncogenic proteins and the secretion of exosome-like extracellular vesicles. Roles of these proteins in host-parasite interactions and pathogenesis of fluke-induced hepatobiliary diseases, including cholangiocarcinogenesis, are discussed. Future directions for the application of this knowledge to control infection and disease will also be discussed.
A brief history and comparison of barrier methods of birth control are reviewed. The clinical trial of theOves
® cervical cap, a new barrier method for contraception, is reported. The aim of this ...study was to evaluate the safety and effectiveness of the Oves
® cervical cap. The Oves
® cervical cap is made of implantable grade silicone which fits snugly over the cervix. Women (N=17) included in the study were followed at 3-months, 6-months and annually during their participation in the study, for a total of 336 women-months. Clinical data consisted of Pap smear at the initial exam, at 3 months, and annually thereafter. Women completed a monthly diary of side effects and history of their use of the cap with sexual activity. Personal use diaries were tabulated for reported side effects. Data were analysed using standard life-expectancy table analysis to determine contraceptive effectiveness rates. Results showed that the contraceptive failure rate was low, the Oves
® cervical cap in this study had a contraceptive effectiveness rate of 100%. There were no serious or severe side effects. Reported side effects consisted of vaginal infection (11 cases in five women) and dislodgement (5 cases). Only one subject discontinued use of the Oves
® cervical cap because of discomfort. Overall, women and their partners reported satisfaction with use of the Oves
® cervical cap. The major limitation of this study was the small sample size. Current efforts are underway to undertake a larger clinical trial in attempt to win FDA approval to market the device in the US.
Inadvertent Knausgaard, Karl Ove; Burkey, Ingvild
09/2018
eBook
The second book in theWhy I Writeseries provides generous insight into the creative process of the award-winning Norwegian novelist Karl Ove Knausgaard"Why I Write" may prove to be the most difficult ...question Karl Ove Knausgaard has struggled to answer yet it is central to the project of one of the most influential writers working today. To write, for the Norwegian artist, is to resist easy thinking and preconceived notions that inhibit awareness of our lives. Knausgaard writes to "erode his own notions about the world. . . . It is one thing to know something, another to write about it." The key to enhanced living is the ability to hit upon something inadvertently, to regard it from a position of defenselessness and unknowing. A deeply personal meditation,Inadvertentis a cogent and accessible guide to the creative process of one of our most prolific and ingenious artists.
NORDIC BUSINESS REPORT-20 November 2000-CONTRACTS: Sweden (C)1998- 2000 M2 COMMUNICATIONS LTD http://www.m2.com Skanska Sverige AB has received a contract award for flatwork from the road maintenance ...office in Malmo (Gatukontoret Malmo), in Sweden. The contract has been valued at SEK19m. Agresso AB has received a contract award for financial information systems from the municipality of Vaxjo, Sweden. The contract has been valued at SEK21m. Scandinavian Terra Tec AB has received a framework contract for geotextiles from Sweden's National Road Administration. No further details have been provided.
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