Purpose:
Traumatic globe rupture can lead to aniridia with subsequent glare, light sensitivity and psychological discomfort. The authors report the results of a sulcus implantation of a new ...intraocular lens with artificial iris (Reper) in an eye affected by traumatic opening of a radial keratotomy incision with total iris extrusion and subluxated cataract.
Methods:
A case of 56-year-old female affected by aniridia and subluxated cataract in left eye secondary to a traumatic opening of one of 12 radial keratotomy underwent a Reper implantation with three-point transcleral fixation. The following parameters were collected at 1, 3 and 6 postoperative months: best-corrected visual acuity (BCVA), intraocular pressure (IOP), central corneal thickness (CCT), simulated keratometry (Sim K), endothelial cell count (ECC) and anterior chamber depth (ACD). Pupil spread function study was performed to evaluate the high-order aberrations and the quality of vision.
Results:
BCVA improved from light perception to 20/20 (Snellen fraction) at 6 postoperative months. No IOP postoperative peaks were detected. CCT was 520 μm at 6 postoperative months. Corneal topography showed regularization with symmetrical flattening of the central part and a residual peripheral curvature. No significant reduction of ECC was detected. ACD was stable, superior to 3 mm at each time point of follow-up. Pupil spread function study highlighted that the quality of vision was the same in both eyes at the end of follow-up.
Conclusion:
Reper is a promising functional and cosmetic solution for the treatment of aphakia and aniridia.
The incidence of kidney disease is rising, constituting a significant burden on the healthcare system and making identification of new therapeutic targets increasingly urgent. The heme oxygenase (HO) ...system performs an important function in the regulation of oxidative stress and inflammation and, via these mechanisms, is thought to play a role in the prevention of non-specific injuries following acute renal failure or resulting from chronic kidney disease. The expression of HO-1 is strongly inducible by a wide range of stimuli in the kidney, consequent to the kidney's filtration role which means HO-1 is exposed to a wide range of endogenous and exogenous molecules, and it has been shown to be protective in a variety of nephropathological animal models. Interestingly, the positive effect of HO-1 occurs in both hemolysis- and rhabdomyolysis-dominated diseases, where the kidney is extensively exposed to heme (a major HO-1 inducer), as well as in non-heme-dependent diseases such as hypertension, diabetic nephropathy or progression to end-stage renal disease. This highlights the complexity of HO-1's functions, which is also illustrated by the fact that, despite the abundance of preclinical data, no drug targeting HO-1 has so far been translated into clinical use. The objective of this review is to assess current knowledge relating HO-1's role in the kidney and its potential interest as a nephroprotection agent. The potential therapeutic openings will be presented, in particular through the identification of clinical trials targeting this enzyme or its products.
Acute mesenteric ishemia(AMI) is a rare but very serious disease with high rate of mortality and morbidity. About 1-2% of all gastrointestinal disease is AMI. Mortality is about 60-80% and depends of ...time between starting of symptoms and establishing of diagnosis, type AMI, comorbidities. AMI is often in older population with coronary syndrom and atrial fibrilation. AMI may be occlusive(embolisatio arteriae mesentericae superior(AMS), or thrombosis of AMS, mesenterial vein thrombosis) and nonoclusive form(NOMI). NOMI is rising in critical ill patients in shock or sepsis. Pathophysiology of AMI is very complex and significant role in this proces has ischemia and also reperfusion. Reperfusion injury including oxidative stres, inflamation, infection. The best diagnostic approach is CT angiography but after high clinical suspicion on AMI. Patients have sudden, catastrophic abdominal pain, vomitus, bloody diarrhoea. Therapy is multidisciplinary-basic treatment(resuscitation with cristaloids, antibiotic, anticoagulans...), surgical treatment-resection necrotic segments of intestinum without anastomosis or endovascular treatment. In early phases conservative treatment is possible( vasodilatation, thrombolysis). In some countries there are Intestinal Stroke Centers (ISC) in which patients with AMI have better prognosis. Because of progressive nature of AMI( rapide worsening) rare are clinical study,but there are many experimental study on animal models. Most of experimental study investigate protective effects of some supstances on damage on intestinum and remote organs during ishemia and reperfusion.
To present literature data of clinical and experimental study, describe experiments on animal models and mention supstances whit promising results in protective strategies during AMI.
We analysed Pubmed by using mesh terms such as acute mesenteric ischemia, intestinal injury, reperfusion, experimental study, clinical and therapeutic approach. Results: Sudden abdominal pain resists on opioids analgetics, high rate of CRP, hyperlactatemia, increase of D dimer is enough for suspicion of AMI. Often is delayed in establishing of diagnosis of AMI. CT angiography has sensitivity of 94%. Pneumatosis is sign of necrosis of intestinal wall. Classical surgical approach is dominant, more than 70%,. Endovascular treatment became often last few years. Experimental studies investigate occlusion of AMS with atraumatic clamp, with schemia and reperfusion in different intervals Most animals models are on wistar male rats.
AMI has still high rate of mortality. Better diagnostic and therapeutic principles (shorter interval between appearance of symptoms and starting of therapy, multidisciplinary approach, higher percent of endovascular procedures), could decrease mortality. Experimental studies on animal models may be succesfull in development of new clinical, conservative approaches in the early phases of AMI in the future.
Ischemia/reperfusion injury (IRI) remains an important problem in clinical transplantation. Following ischemia, phosphatidylserine (PS) translocates to surfaces of endothelial cells (ECs) and ...promotes the early attachment of leukocytes/platelets, impairing microvascular blood flow. Diannexin, a 73 KD homodimer of human annexin V, binds to PS, prevents attachment of leukocytes/platelets to EC, and maintains sinusoidal blood flow. This study analyzes whether Diannexin treatment can prevent cold IRI in liver transplantation. Rat livers were stored at 4°C in UW solution for 24 h, and then transplanted orthotopically (OLT) into syngeneic recipients. Diannexin (200 μg/kg) was infused into: (i) donor livers after recovering and before reperfusion, (ii) OLT recipients at reperfusion and day +2. Controls consisted of untreated OLTs. Both Diannexin regimens increased OLT survival from 40% to 100%, depressed sALT levels, and decreased hepatic histological injury. Diannexin treatment decreased TNF‐α, IL‐1β, IP‐10 expression, diminished expression of P‐selectin, endothelial ICAM‐1, and attenuated OLT infiltration by macrophages, CD4 cells and PMNs. Diannexin increased expression of HO‐1/Bcl‐2/Bcl‐xl, and reduced Caspase‐3/TUNEL+ apoptotic cells. Thus, by modulating leukocyte/platelet trafficking and EC activation in OLTs, Diannexin suppressed vascular inflammatory responses and decreased apoptosis. Diannexin deserves further exploration as a novel agent to attenuate IRI, and thereby improve OLT function/increase organ donor pool.
Diannexin, a recombinant homodimer of human annexin V, decreases vascular inflammation and ischemiareperfusion injury in cold‐stored rat livers orthotopically transplanted into syngeneic recipients.
Este estudio tuvo como propósito central documentar el conocimiento tecnológico y pedagógico del contenido de un profesor de química ejemplar cuando implementa el objeto de aprendizaje "cuando ...utilizamos diferentes unidades de concentración". Esta fue una investigación cualitativa mediante la modalidad de estudio de caso. Con el fin de dar confiabilidad a los resultados, los datos fueron recogidos a través de fuentes documentales como relatos, videos de las clases, observación no participante y trabajos de los estudiantes. Esta investigación produjo una gran cantidad de información que fue analizada desde la perspectiva de la teoría fundamentada, de lo cual se generaron cuatro categorías, a saber: 1) la pedagogía general, en conjunción con las habilidades lingüísticas y las relaciones cuantitativas median la comprensión de las unidades de concentración; 2) la enseñanza del tópico solubilidad, un medio para desarrollar las competencias que demanda la actual sociedad del conocimiento; 3) el principio de la intertextualidad, elemento fundamental para representar el tópico de los objetos de aprendizaje; y 4) la enseñanza de unidades de concentración en relación con la evaluación formativa y las pruebas de naturalezaestandarizada. El desarrollo teórico de estas categorías se tradujo en los relatos de experiencias profesionales y pedagógicas (PaP-eR), que representaron los procesos de razonamiento y acciones pedagógicas realizadas por el profesor ejemplar durante la implementación del objeto de aprendizaje.
Two choir formations are featured in connection with minority-majority relations, under socially and music related aspects. The focus lies on creative forms of self-help and on music cultural ...interactions as reflected in the music repertoire and elaborated through analyzing structure and building elements of single music pieces.
V prispevku je predstavljen predlog za novo oštevilčevanje nivelmanskih poligonov in reperjev. Obravnavana je tudi analiza natančnosti izmerjenih višinskih razlik, opravljena na podlagi odstopanj ...obojestransko merjenih višinskih razlik in odstopanj pri zapiranju nivelmanskih zank. Na podlagi izravnave nivelmanske mreže in nivelmanskih poligonov je analizirana tudi natančnost na podlagi popravkov merjenih višinskih razlik in izvedena ocena natančnosti določitve nadmorske višine reperjev ; This paper presents a proposal for a new numbering of levelling polygons and benchmarks. Furthermore, an accuracy analysis is done with regard to: measured height differences, residuals calculated from differences of the forward and backward runs, residuals from loop closures, and results from network adjustments.
Neutrophil plays an important role in hepatic ischemia-reperfusion injury. We investigated neutrophil infiltration in liver tissue, Kupffer cells' role in neutrophil accumulation, and apoptosis and ...regeneration of hepatocytes in liver ischemia-reperfusion injury.
Vascular microclamps were placed across the pedicles of the median and left lateral lobes for 90 minutes after 30% hepatectomy with the resection of caudate, right lateral and quadrate lobes and papillary process. Gadolinium chloride (GdCl(3)) was used to destroy Kupffer cells. Neutrophil activity was inhibited with Urge-8, a monoclonal antibody against neutrophil produced in our laboratory. GdCl(3) (10 mg/kg) and Urge-8 (50 mg/kg) were given intravenously in respective groups. Ischemia control, GdCl(3) and Urge-8 groups were compared.
Following hepatic reperfusion, serum interleukin-8 (IL-8) levels and hepatic neutrophil counts peaked at 3 hours, and peak concentrations of alanine aminotransferase (ALT) occurred at 6 hours. Animals of the control group showed increases in neutrophil infiltration in liver tissue, liver enzyme levels, and apoptosis index of hepatocytes and decreases in overall survival rate and proliferating cell nuclear antigen (PCNA) expression of hepatocytes. The survival rates and PCNA proportion of hepatocytes were higher and the levels of hepatic neutrophil infiltration, liver enzymes, and hepatocyte apoptosis after reperfusion were lower in the GdCl(3) and Urge-8 groups than those in the ischemia control group.
Blockades of Kupffer cells' activity and neutrophil infiltration by GdCl(3) and Urge-8 eliminate neutrophil-mediated hepatic injury and enhance subsequent hepatic regeneration during liver ischemia-reperfusion.
U ovom je radu dan prikaz geodetskoga određivanja pomaka objekta »Malančec«. Objašnjen je postupak mjerenja i naveden je instrumentarij primijenjen u ovom projektnom zadatku.
Na posljetku je izrađen ...izvještaj obavljenih mjerenja, u tabličnom obliku i u obliku dijagrama.
Ovaj je rad nastao kao rezultat suradnje geodetske i građevinske struke na objektu koji je zaštićeni spomenik kulture.
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