Researchers worldwide are taking advantage of novel, commercially available, technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and lipidomics applications in a variety of ...fields including life, biomedical, and food sciences. IM‐MS provides three main technical advantages over traditional LC‐MS workflows. Firstly, in addition to mass, IM‐MS allows collision cross‐section values to be measured for metabolites and lipids, a physicochemical identifier related to the chemical shape of an analyte that increases the confidence of identification. Second, IM‐MS increases peak capacity and the signal‐to‐noise, improving fingerprinting as well as quantification, and better defining the spatial localization of metabolites and lipids in biological and food samples. Third, IM‐MS can be coupled with various fragmentation modes, adding new tools to improve structural characterization and molecular annotation. Here, we review the state‐of‐the‐art in IM‐MS technologies and approaches utilized to support metabolomics and lipidomics applications and we assess the challenges and opportunities in this growing field.
The Left Behind series by Tim LaHaye and Jerry B. Jenkins has become a popular culture phenomenon, selling an astonishing 40 million copies to date. These novels, written by two well-known ...evangelical Christians, depict the experiences of those left behind in the aftermath of the Rapture, when Christ removes true believers, leaving everyone else to suffer seven years of Tribulation under Satan's proxy, Antichrist.
In Marks of the Beast , Shuck uncovers the reasons behind the books' unprecedented appeal, assessing why the novels have achieved a status within the evangelical community even greater than Hal Lindsey's 1970 blockbuster The Late Great Planet Earth . It also explores what we can learn from them about evangelical Christianity in America.
Shuck finds that, ironically, the series not only reflects contemporary trends within conservative evangelicalism but also encourages readers—especially evangelicals—to embrace solutions that enact, rather than engage, their fears. Most strikingly, he shows how the ultimate vision put forth by the series' authors inadvertently undermines itself as the series unfolds.
•Improving PV-TEG efficiency by tackling metal surface and air gap thermal challenges.•Proposing mathematical modeling for predictive performance evaluation of PV-TEG systems.•Investigating the ...effectiveness of PGS as a TIM in PV-TEG systems.•Assessment of three cooling approaches: natural air, forced air, and forced water.•Bent PGS configuration proves most effective in reducing PV panel temperature to enhance power generation.
PV-TEG systems utilize waste heat by using TEGs under PV panels. TEGs improve the efficiency of PV and generates more energy. However, rough metal surfaces at contact points reduce the system's thermal efficiency and create air gaps. This paper employs a mathematical model based on principles of thermal resistances and energy conservation. The proposed model is built using MATLAB R2020a. The paper assessed the effectiveness of a Pyrolytic Graphite Sheet (PGS) as a Thermal Interface Material (TIM) in PV-TEG systems and three cooling approaches. The investigation explores two configurations (parallel and bent) of PGS and five TIM materials. The results indicate that bent PGS is the most effective. It lowers the temperature of the PV panels to 18.99 ℃, 19.95 ℃, and 20.74 ℃. As a result, the power increased to 0.606 W, 0.639 W, and 0.667 W. Additionally, the efficiency improves to 1.66 %, 1.75 %, and 1.82 % with natural air, forced air, and forced water cooling, respectively. The results show that PGS can improve PV-TEG system performance and solve thermal issues with metal surfaces and air gaps.
Vietnam and Beyond: Tim O’Brien and the Power of Storytelling is a comprehensive, in-depth study of one of the most thought-provoking writers of the Vietnam war generation. This volume breaks away ...from previous readings of O’Brien’s development as a trauma artist and an outspoken chronicler of the American involvement in Vietnam: its thematic, rather than chronological, approach contextualizes O’Brien’s work beyond the confines of war literature. The necessary exploration of O’Brien’s recurrent engagement with the conflict in Vietnam leads to a thorough discussion of the writer’s revision of key American (and western) ideas and concerns: the association between courage, heroism and masculinity, the celebration of the pioneering spirit in the frontier narrative, the sense of superiority in the encounter with foreign civilizations, the fraught relationship between power and truth, or reality and imagination, and the attempt and the right to speak about unspeakable events. All these themes, as Ciocia illustrates, highlight O’Brien’s compelling preoccupation with the role and the ethical responsibility of the storyteller. With his clear privileging of ‘story-truth’ over ‘happening-truth’, O’Brien makes a bold, serious investment in the power of fiction, as testified by his formal experimentations, metanarrative reflections and sustained meditations on matters such as individual agency, moral accountability and authenticity. Approached from this fresh perspective, O’Brien emerges as a figure deserving to find a wider audience and demanding renewed scholarly attention for his remarkable achievements as a contemporary mythographer, an acute observer of the human condition and a sharp critic of American culture.
Hydrolytic enzymes are highly demanded in the industry. Thermostability is an important property of enzymes that affects the economic costs of the industrial processes. The rational design of GH10 ...xylanase E (XylE) Penicillium canescens for the thermostability improvement was directed by ΔΔG calculations and structure analysis. Amino acid substitutions with stabilizing values of ΔΔG and providing an increase in side-chain volume of buried residues were performed experimentally. From the six designed substitutions, four substitutions appeared to be stabilizing, one – destabilizing, and one – neutral. For the improved XylE variants, values of Tm were increased by 1.1–3.1 °C, and times of half-life at 70 °C were increased in 1.3–1.7-times. Three of the four stabilizing substitutions were located in the N- or the C-terminus region. This highlights the importance of N- and C-terminus for the thermostability of GH10 xylanases and also enzymes with (β/α)8 TIM barrel type of structure. The criteria of stabilizing values of ΔΔG and increased side-chain volume of buried residues for selection of substitutions may be applied in the rational design for thermostability improvement.
Display omitted
•Substitutions were selected due to stabilizing values of ΔΔG and structure changes.•Buried residues were substituted with residues with increased side-chain volume.•Substitutions in the N- and C-terminus region provided thermostabilization.•Tm was increased by 1.1–3.1 °C, t1/2 at 70 °C was increased in 1.3–1.7-times.
Jeannerat H. and Kebir L. Knowledge, resources and markets: what economic system of valuation?, Regional Studies. Exploring in ever more detail learning processes at the root of economic change, main ...territorial innovation models (TIMs) remain focused on production today. Thus consumption is most often assessed as an abstract demand expressed by exogenous market mechanisms. In a socio-institutional approach, this article conceptualizes an economic system in which knowledge is a constructed resource valued in a market through the co-evolution of a production and a consumption system. From a meta-synthesis of various case studies, the paper draws four ideal types of economic systems and their related territorial knowledge dynamics (TKDs): knowledge marketization, knowledge improvement, knowledge adaptation and knowledge co-development.
La web está tan presente en la sociedad actual que se identifica Web con Internet convirtiéndose sinónimos, pero en 1989 esto no era así. Durante los veinte años anteriores a 1989, cuando nació la ...Web, un grupo de científicos de varios países, fundamentalmente, Estados Unidos, había desarrollado las bases de Internet. En los años 70 y 80, Internet permitía la comunicación mediante correo electrónico, la descarga de ficheros (FTP) o incluso el control remoto de un ordenador a través del protocolo Telnet. Con el tiempo, la World Wide Web ha ido asumiendo todos estos servicios y otros más. Este artículo analiza el origen y los principios sobre los que se creó Web, cómo grandes empresas se han hecho con su dominio y los esfuerzos de su creador en estos últimos años de explicar al mundo que otra forma de generar y compartir conocimiento es no solo posible, sino deseable. Palabras clave: Información; Web; Tim Berners-Lee; conocimiento; Internet. The web is so present in today's society that the web is identified with the Internet and has become synonymous, but in 1989 this was not the case. During the twenty years prior to 1989, when the Web was born, a group of scientists from various countries, mainly the United States, had developed the foundations of the Internet. In the 1970s and 1980s, the Internet allowed communication by e-mail, downloading files (FTP) or even remote control of a computer via the Telnet protocol. Over time, the World Wide Web has taken over all these services and more. This article analyses the origin and principles on which the Web was created, how large companies have taken over its domain and the efforts of its creator in recent years to explain to the world that another way of generating and sharing knowledge is not only possible, but desirable. Keywords. Information; Web; Tim Berners-Lee; knowledge; Internet.
PDF
