In Feminist, Queer, Crip Alison Kafer imagines a different future for disability and disabled bodies. Challenging the ways in which ideas about the future and time have been deployed in the service ...of compulsory able-bodiedness and able-mindedness, Kafer rejects the idea of disability as a pre-determined limit. She juxtaposes theories, movements, and identities such as environmental justice, reproductive justice, cyborg theory, transgender politics, and disability that are typically discussed in isolation and envisions new possibilities for crip futures and feminist/queer/crip alliances. This bold book goes against the grain of normalization and promotes a political framework for a more just world.
The polyphenol trans‐resveratrol (t‐RES) is present as t‐RES‐3‐O‐β‐D‐glycoside, termed piceid, in several plant‐derived foods. Although data on the metabolism and on in vivo effects of t‐RES have ...been reported, quantitative data on the metabolites formed after dietary intake of t‐RES or piceid are still lacking. In this study, 85.5 mg of piceid per 70 kg of body weight (bw) were administered to healthy volunteers in a bolus dose. t‐RES metabolites formed in plasma and urine were identified and quantified by LC‐MS/MS, NMR, and HPLC‐DAD analysis using chemically synthesized t‐RES conjugate standards. In addition, the amount of t‐RES metabolites bound noncovalently to plasma proteins was determined for the first time in humans. The metabolites identified and quantified were t‐RES‐3‐sulfate, t‐RES‐3,4′‐disulfate, t‐RES‐3,5‐disulfate, t‐RES‐3‐glucuronide and t‐RES‐4′‐glucuronide, with t‐RES‐sulfates being the dominant conjugates in plasma and urine. Besides these metabolites, two novel t‐RES‐C/O‐conjugated diglucuronides have been identified and quantified in plasma and urine. Moreover, it could be shown that up to 50% of the plasma t‐RES‐3‐sulfate, t‐RES‐disulfates, and the novel t‐RES‐C/O‐diglucuronides were bound to proteins. Total recovery of the dietary administered piceid in urine ranged between 13.6 and 35.7%.
Transient receptor potential vanilloid 3 (TRPV3) is a Ca2+- and Na+-permeable channel with a unique expression pattern. TRPV3 is found in both neuronal and non-neuronal tissues, including dorsal root ...ganglia, spinal cord, and keratinocytes. Recent studies suggest that TRPV3 may play a role in inflammation, pain sensation, and skin disorders. TRPV3 studies have been challenging, in part due to a lack of research tools such as selective antagonists. Herein, we provide the first detailed report on the development of potent and selective TRPV3 antagonists featuring a pyridinyl methanol moiety. Systematic optimization of pharmacological, physicochemical, and ADME properties of original lead 5a resulted in identification of a novel and selective TRPV3 antagonist 74a, which demonstrated a favorable preclinical profile in two different models of neuropathic pain as well as in a reserpine model of central pain.
This study builds and evaluates a transgender privacy paradox impression management (TPPIM)' model to examine the influence of social networking site impression management (IM) on transgender users' ...sustained SNS involvement, contributing a new view to the field of information systems research. The study finds no direct relationship between privacy paradox and transgender individuals' online social media persona. However, transgender individuals, to enjoy an uninterrupted social media presence and protect their privacies, employ various impression management strategies on social media, which fully mediate the relationship between the privacy paradox and their social media personas. Transgender individuals use their social media presence to find resources required for their day-to-day survival, indicating that an active social media presence is not optional but mandatory. Users value privacy, however, they consciously or unconsciously implement privacy averseness for an active social media presence. The authors use a mixed methodology where qualitative analysis findings informed hypotheses and model development of a structural model that used 299 useable responses and PLS/SEM to test and confirm that trans impression management mediates the relationship between the trans privacy paradox and transgender persons' Facebook behavior. This study enhances model complexity relative to earlier work, mediating the investigation's hypothesized behavioral correlations. Complementing current SNS research, it highlights the complexity of social networking behavior, the suitability of impression management theory to describe dynamically evolving social structures, and how social capital drives impression management.
•Transgender privacy paradox impression management (TPPIM) model posited and tested.•Transgender-Privacy concerns, Privacy averseness, Privacy paradox, Impression Management and Facebook Persona examined.•Privacy paradox construct defined in transgender perspective.•Privacy paradox mediates transgender impression management and SNS behaviors•Impression management engagement allows enjoying social media presence in privacy.
Trans fats are desired by the edible oil industry as they impart firmness, plasticity, and oxidative stability to oil. However, clinical trials have demonstrated the adverse effects of trans fats in ...food on human health and nutrition. Regulatory actions have been taken up by government and non‐government bodies worldwide to eliminate the presence of trans fats in the food supply. The World Health Organization (WHO) has launched a “REPLACE” action plan to eliminate trans‐fat from the global food industry by 2023. A few enabling technologies are developed to mitigate trans fats namely, trait‐enhanced oils, modification in the hydrogenation process, interesterification, fractionation, blending, and oleogelation. Some of them have the drawback of replacing trans‐fat with saturated fats. Interesterification and oleogelation are in‐trend techniques with excellent potential in replacing trans fats without compromising the desired functionality and nutritional quality attributes. This review presents an overview of trans fatty acid for example, its dietary intake in food products, possible adverse health impact, regulations, and approaches to reduce the usage of trans fats for food application.
Practical Application
The requirement for the replacement of trans fatty acids (TFAs) in food supply globally has challenged the food industry to find a novel substitute for trans fats without compromising the desired functionality and nutritional property. This review presents detailed background on trans fats, their health impacts and current trends of reformulation of oils and fats to mitigate their presence in food supply chains. Information compiled in this paper will help food scientists and technologists, chemists, food processors, and retailers as there is an urgent need to find novel technologies and substitutes to replace trans fats in processed foods.
Drawing on unique research and rich data on cross-border practices, this book offers an empirically-based view on Europeans' interconnections in everyday life. It looks at the ways in which EU ...residents have been getting closer across national frontiers: in their everyday experiences of foreign countries - work, travel, personal networks - but also their knowledge, consumption of foreign products, and attitudes towards foreign culture.
These evolving European dimensions have been enabled by the EU-backed legal opening to transnational economic and cultural transactions, while also differing according to national contexts. The book considers how people reconcile their increasing cross-border interconnections and a politically separating Europe of nation states and national interests.
During the last ten years, transcatheter aortic valve implantation (TAVI) has become a reliable and valid alternative treatment for elderly patients with severe symptomatic aortic valve stenosis ...requiring valve replacement and being at high or intermediate surgical risk. While common femoral arteries are the access site of choice in the vast majority of TAVI patients, in up to 15-20% of TAVI candidates this route might be precluded due to the presence of diffuse atherosclerotic disease, tortuosity or small vessel diameter. Therefore, in order to achieve an antegrade or retrograde implant, several alterative access routes have been described, namely trans-axillary, trans-aortic, trans-apical, trans-carotid, trans-septal, and trans-caval. The aim of this paper is to give a concise overview on vascular access sites for TAVI, with a particular focus on patient's selection criteria, imaging, technical aspects, and clinical outcome.
This open access book is a groundbreaking volume that creates a new field within the intersection of “global health” and “LGBTQ health” delineating specific health challenges and resiliencies. There ...has been increasing awareness of the importance in recognizing LGBTQ health issues and disparities. However, there is a dearth of research and scholarship that examines LGBTQ health through global and comparative perspectives. This book addresses this gap. In the pursuit of scientific inquiry, the disciplines in public health have often emphasized reductionist perspectives that are particularized to a specific locale, municipality, or country. This book's provision of broader perspectives, cross-cutting disparities and issues, and socio-political-cultural contextualization inform the development of new research, policies, interventions, and programs. Students benefit by learning about LGBTQ health research, policies, and programs in various countries and regions. Public health researchers benefit by learning about research conducted in various countries and regions, along with understanding how research has been linked to and impacted by various policies and programs. Policymakers benefit from learning about overarching and comparative perspectives that could inform more effective policies, including those connected to multiple locations. Practitioners learn about various public health practices in multiple countries and regions that could contribute to novel and creative solutions and approaches within the respective contexts. The nine chapters of this volume facilitate greater socio-political-cultural awareness, sensitivity, and competence; undertake an in-depth literature review of health factors and outcomes; and provide recommendations for increasing health-related capacity through development and collaborations between agencies, organizations, and institutions across countries and/or regions. Global LGBTQ Health: Research, Policy, Practice, and Pathways is primarily intended for students and instructors in public health, medicine, nursing, other health professions, psychology, social work, LGBTQ or gender/sexuality studies, human rights, and the social sciences. The book is also a useful resource for public health researchers and practitioners, policymakers, and healthcare and social service providers.
Biological Implications of Lipid Oxidation Products Vieira, Samantha A.; Zhang, Guodong; Decker, Eric A.
JAOCS, Journal of the American Oil Chemists' Society,
March 2017, Letnik:
94, Številka:
3
Journal Article, Book Review
Recenzirano
Essentially all fat-containing foods have the potential to undergo lipid oxidation even where unsaturated fatty acid compositions are low. Therefore, consumption of lipid oxidation products is ...potentially common with risk of consuming lipid oxidation products increasing in foods with high amounts of unsaturation (e.g. foods with omega-3 fatty acids), foods subjected to extensive thermal processing (e.g. fried foods), or food high in pro-oxidants (e.g. meats). Lipid oxidation generates potentially toxic products that have shown correlation with inflammatory diseases, as well as cancer, atherosclerosis, aging, etc. These potentially toxic products can enter the body through the diet and can develop
in vivo
during the digestion of lipids. Oxidation products can be absorbed into the blood and in some cases transported to tissues. The aim of this manuscript is to review how potentially toxic lipid oxidation products are formed and evaluate their potential to impact health. While lipid oxidation produces literally hundreds of oxidation products, this review focused on acrolein, 4-hydroxy-
trans
-nonenal, 4-hydroxy-
trans
-hexanal, crotonaldehyde, malondialdehyde, and cholesterol as they are the most reactive oxidation products and also the most studied.
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