Propionic acid bacteria (PAB) are extremely important because of the metabolites they produce (vitamins, propionic acid, conjugated linoleic acid, and bioactive peptides). Nowadays, the increasing ...interest in healthy nutrition has led to the formation of the concepts of probiotics, postbiotics and functionality with studies. Vitamin B12 is one of the postbiotics produced by PAB and is known to be beneficial for human health. Due to its coenzyme feature, it plays a key role in the body process, as well as shows anti-inflammatory properties. The recommended dietary intake of vitamin B12 for adults is 4 μg/day. Although it is highly found in meat products, it is known that the bioavailability of B12 in dairy products is higher. Fermented dairy products, especially products that contain PAB in their natural microflora, are good tools for the production and intake of vitamin B12. In this study, the factors affecting the microbial production of vitamin B12 were examined.
Abstract
Objective
Certain cancer types have been shown to be associated with vitamin D deficiency. The aim of this study was to appraise the relationship between the vitamin D receptor (VDR) gene ...single nucleotide polymorphisms (SNPs) of VDR Fok1 and Bsm1 with serum vitamin D, calcium and phosphorus levels among patients of lung, colon, breast and pancreatic cancer patients.
Materials and methods
Groups; lung, colon, breast and pancreatic cancer patients (n=212) and 58 age-matched healthy controls. Serum levels of vitamin D were measured by immunochemiluminesence method and Fok1 and Bsm1 genotypes were assessed with Real-Time Polymerase Chain Reaction.
Results
VDR Fok1 and Bsm1 genetic polymorphisms have a significant difference between lung cancer and control group subjects (p=0.042, p=0.040, respectively). VDR Bsm1 genetic polymorphism has a significant association between breast cancer and control group according to the logistic regression model (p=0.038). Vitamin D levels were found significantly lower in all cancer groups (p<0.01). Phosphorus levels of lung cancer and calcium levels of pancreatic cancer patients were statistically significantly lower than control group (p<0.02, p<0.01).
Conclusion
This study indicates that VDR genetic polymorphisms, calcium, phosphorus and vitamin D status of individuals were associated with certain cancer species.
This study was carried out to determine the effects of irrigation levels on yield and quality of paprika pepper under Harranplain conditions of Turkey. Different water stress levels under drip ...irrigation system were created by applying 125% ofcumulative Class-A Pan evaporation (CAP125), 100% (CAP100), 75% (CAP75) and 50% (CAP50) of cumulative class-A-pan(CAP) evaporation in every 3 days. Besides, an irrigation treatment with IRSIS (Irrigation Scheduling Information System)computer program was created and applied as an alternative irrigation program. Three paprika pepper cultivars (Ace, Kingand Queens) were tested. Experiments were conducted in randomized blocks split plots design with 3 replications in 2005at Koruklu Station of GAP Regional Development Administration located in Harran Plain of Şarlıurfa, Turkey. Appliedirrigation water amount and ET (Evapotranspiration) values for IRSIS treatment were 874 mm and 908 mm, respectively.Applied irrigation amount and ET values of CAP125 and CAP50 were between 254-568 mm and 368-602 mm, respectively.The highest yield was obtained from IRSIS treatment with 25.63 t ha-1 and the lowest yield was obtained from CAP50 with11.72 t ha-1. The yield was significantly affected by cultivar, irrigation and cultivar × irrigation interactions. The averagemoisture, ASTA (American Spice Trade Association), capsaicin, vitamin C and beta-carotene contents were respectivelyvaried between 83.96 – 84.76%, between 225.76–286.22 mg kg-1, between 1404.11–2408.11 mg kg-1 and between 77.88–113.00 mg kg-1. Beta-carotene contents were not affected significantly by the cultivars, irrigations and interactions. Theeffects of irrigation and interactions on vitamin C and capsaicin were not also significant while the effects of cultivaron vitamin C and capsaicin were significant at P
D vitamini intoksikasyonu, hiperkalseminin nadir bir sebebidir. Genellikle iyatrojenik olup, uygunsuz dozda D vitamini alınmasına bağlıdır. 58 yaşında erkek hasta, iştahsızlık, kas ağrıları ve ...poliüri nedeni ile acil servise başvurdu. Ayrıntılı son anamnezinde, 1 ay içinde, 5 adet D vitamini kullanım hikâyesi vardı. D vitamini intoksikasyonu düşünülen hasta, hiperkalsemiye bağlı aritmi nedeniyle exitus olmuştur. Bu olgu sunumunda yanlış ve gereksiz olarak yüksek doz D vitamini kullanımı ve komplikasyonlarının değerlendi- rilmesi amaçlanmıştır
Amaç: Bu çalışma, annelerin D vitamini hakkındaki bilgileri ve D vitamini kullanma tutumlarının değerlendirilmek amacıyla yapılmıştır. Gereç ve Yöntem: Ankara Eğitim ve Araştırma hastanesi sağlam ...çocuk polikliniğine Mart 2013-Nisan 2014 tarihleri arasında başvuran ve 0-3 yaş arasında çocuğu olan 476 anne çalışmaya alınmıştır. Yüz yüze anket metodu yöntemi kullanarak anneye ait sosyodemografik özellikler, D vitamini hakkındaki bilgileri ve kullanma tutumlarına ait sorular sorularak veriler toplandı. Veriler; sayı, yüzde ve Ki-Kare analizleriyle değerlendirildi. Bulgular: Annelerin %31.7'si 25-33 yaş aralığında, %31.7'si ilkokul mezunu idi. İlk altı ay sadece anne sütü verenlerin oranı %18.4 idi. Annelerin tamamı günde üç damla D vitamini kullanmaları gerektiği bilgisine sahip idi. Çocuklarına düzenli D vitamini veren annelerin oranı %67.2 idi. Annelerin eğitim durumları ile D vitaminin düzenli kullanma tutumları arasında fark saptanmadı (p>0.05). Gebelik döneminde D vitamini kullandıklarını ifade eden annelerin oranı %56.0 idi. Annelerin %49.2'si ıspanağın D vitamininde zengin besin olduğunu, %61.12'i fazla D vitamini verilmesi halinde “bıngıldağın erken kapanacağını” düşünmekte idi. Annelerin tamamı güneş ışığının kemik gelişimine faydalı olduğu bilgisine sahipti. Sonuç: Annelerin D vitaminini kullanma tutumları olumludur. Annelerin gebelikleri ve emzirme döneminde D vitamini kullanma bilgileri ve tutumları eksiktir. D vitamini kullanma süresi, D vitamini kaynaklarına dair bilgileri yeterli değildir.
Objective: This study was conducted in order to evaluate the knowledge, attitude and practice of mothers about vitamin D supplementation. Materials and Methods: This study was conducted among 476 mothers with 0-3 years old children who attended the Ankara Training and Research Hospital Child Health Polyclinic between March 2013 and April 2014. Using the face to face questionnaire method, mothers were asked about their socio-demographic characteristics and their knowledge, attitude and practice about vitamin D supplementation. Results: 31.7% of the mothers were between the ages of 25-33 years, 31.7% them were primary school graduates. 18.4% of the mothers gave breast milk during the first six months. All mothers knew that they should use 3 drops of vitamin D every day. A total of 67.2% of the mothers regularly supplemented their children with vitamin D and 49.2% of them thought that spinach was vitamin D rich food. All mothers thought that sunlight was good for bone development and according to 61.12% of them, more vitamin D consumption would provide earlier closure of the anterior fontanel. Conclusion: The attitude of the mothers regarding vitamin D usage is favorable. But their knowledge and attitude about vitamin D usage during pregnancy and lactation period is inadequate. Their knowledge about the sources for vitamin D and the duration of vitamin D usage are also inadequate.
Abstract
Objective
Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme that regulates the metabolism of methionine and folate.
MTHFR
C677T polymorphism was reported to be associated ...with breast and ovarian cancer. The aim of this study was to evaluate the association between the
MTHFR
C677T (rs1801133) polymorphism and homocysteine, vitamin B12, and folate levels, and DNA fragmentation in patients with ovarian cancer and healthy controls.
Materials and methods
This case-control study was conducted in Istanbul University Cerrahpasa Medical Faculty. We studied 50 ovarian cancer patients and 54 healthy controls. The
MTHFR
C677T polymorphism was determined by PCR followed by restriction fragment length polymorphism (RFLP) and agarose gel electrophoresis. DNA fragmentation was assessed by the comet assay. Homocysteine levels were measured by ELISA, whereas vitamin B
12
and folate levels were measured by chemiluminescence methods.
Results
We found no correlation between the
MTHFR
C677T polymorphism and ovarian cancer. No significant difference was found in homocysteine, folate, and vitamin B
12
levels between patient and control groups. Increased DNA fragmentation was detected in patients with ovarian cancer.
Conclusion
Our findings suggest that
MTHFR
C677T polymorphism, as well as homocysteine, folic acid, and vitamin B12 levels, are not associated with an increased risk for ovarian cancer.
Vitamini skupine B u psihijatriji Bundalo, Daniela; Srkalović Imširagić, Azijada
Medicus (Zagreb, Croatia : 1992),
11/2013, Letnik:
22, Številka:
2_Respiratorni_Konti
Journal Article
Recenzirano
Odprti dostop
U ovome preglednom radu opisana su potencijalna djelovanja vitamina skupine B u ovim psihijatrijskim entitetima: depresiji, shizofreniji i alkoholizmu. Manjak vitamina B2 (ribofl avina) povezan je s ...razvojem depresije, a njegov nedostatak jedna od najčešćih hipovitaminoza u prehrani našeg stanovništva koja se povezuje s nedovoljnom potrošnjom mlijeka i mliječnih proizvoda. Uz nutritivni defi cit folata, malapsorpcija vitamina B12 česta je pojava i može biti povezana s patofi ziologijom shizofrenije. Zlouporaba alkohola i alkoholni sindrom sustezanja povezani su s više neuropsihijatrijskih sindroma od kojih su neki etiološki vezani za nedostatak vitamina B-grupe i stoga nadoknada tih vitamina ima važnu ulogu u profi laksi i liječenju ovih sindroma. Ovo je posebno važno za prevenciju Wernickeove encefalopatije. Zato se za prevenciju razvoja Wernickeove encefalopatije preporučuje pri prijmu u intenzivnu njegu svim osobama koje su pod rizikom od razvoja te bolesti prije primjene glukoze ili drugih ugljikohidratnih otopina dati parenteralno 200 mg tiamina. U nekim se zemljama kod svih pacijenata s epileptičkim statusom parenteralno daje tiamin prije bilo koje infuzije ugljikohidrata. Za primjenu u alkoholizmu peroralni pripravak vitamina B (Plibex) ima i registriranu indi kaciju koja glasi: liječenje hipovitaminoze i avitaminoze (beriberi, aribofl avinoza, pelagra); bolesti kože, neuritisa, neuralgija, polineuritisa i kardiomiopatije zbog nedostatka vitamina u kroničnih alkoholičara.
Homocistein je metabolit nastao u procesu demetilacije metionina. Ima proaterogeno, protrombotsko, prooksidativno, proapoptotsko, neurotoksično, neuroinflamatorno i neurodegenerativno djelovanje. ...Hiperhomocisteinemija je povezana s postojanjem mutacije C667T MTHFR, sniženjem razine folne kiseline i vitamina B-grupe, ali i s dugotrajnim uzimanjem nekih lijekova. Provedeno je istraživanje u Klinici za neurologiju Univerzitetskoga kliničkog centra u Tuzli. Mjerene su razine homocisteina u šezdeset ispitanika obaju spolova u akutnoj fazi ishemijskog cerebrovaskularnog inzulta, a potom su praćeni efekti medikamentnog pristupa (folna kiselina, vitamini B-grupe) šestomjesečno u sljedeće tri godine. Hiperhomocisteinemija je bila prisutna u 16,67% bolesnika, a prosječna razina bila je viša u pacijenata muškog spola (p=0,073). Svaki treći oboljeli muškarac (33,3%) imao je povišene razine (p < 0,001), dok u bolesnica nije uočena hiperhomocisteinemija. Prilikom unosa folne kiseline u dnevnoj dozi od 5 mg peroralnim putem razine homocisteina bile su normalizirane u svih, ali su nekima dodatno ordinirani i vitamini B-grupe.
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