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  • The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF- [alpha] levels and IMT-F [Elektronski vir]
    Gorenjak, Vesna, 1991- ...
    Triggering receptor expressed on myeloid cells 2 (TREM2) is known for its anti-infammatory properties during the immune response, and infuences negatively on TNF-[alpha] expression levels. Genetic ... epidemiology studies have identifed polymorphisms located in the TREM2 gene associated with neurodegenerative and chronic infammatory diseases. TREM2 levels have been observed to afect plasma levels of TNF-[alpha] and plaque stability in symptomatic and asymptomatic patients with carotid stenosis. In this study, we investigated polymorphisms located in the TREM2 gene region and association with TNF-[alpha] levels and the intima media thickness of the femoral artery. The discovery population from the STANISLAS Family Study comprised of 809 individuals, whereas the replication population utilized an independent cohort of French origin (n=916). Our results suggest that the minor allele (T) of SNP rs6918289 is positively associated with elevated plasma levels of TNF-[alpha] in discovery and replication populations (P=0.0026, SE=0.04 and P=0.023, SE=0.09, respectively), including femoral artery thickness in the discovery cohort (P=0.026, SE=0.009). Results indicate that rs6918289 may be considered as a risk factor for infammatory diseases and could be used in stratifed medicine with patients diagnosed with chronic infammatory-related conditions, such as atherosclerosis.
    Vir: Scientific reports [Elektronski vir]. - ISSN 2045-2322 (Vol. 8, art. no. 7160, May 2018, str. 1-8)
    Vrsta gradiva - e-članek
    Leto - 2018
    Jezik - angleški
    COBISS.SI-ID - 56735491

    Povezava(-e):

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940861/pdf/41598_2018_Article_25553.pdf
    DOI

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