NUK - logo
Univerzitetna knjižnica Maribor (UKM)
Knjižnica je med tednom odprta od 8. do 19. ure, ob sobotah od 9. do 13. ure. Čitalnica ČUK je odprta od ponedeljka do sobote od 9. do 24. ure, ob nedeljah od 16. do 24. ure. Informacije: 02 25 07 431, ukm@um.si
PDF
  • Genetic etiology of primary premature ovarian insuffiency
    Franic Ivanisevic, Maja ...
    Primary premature ovarian insufficiency (PPOI) is characterized by hypergonadotropic amenorrhea and hypoestrogenism in women under 40 years of age. PPOI incidence is 1:10,000 in women aged 18-25, ... 1:1000 in women aged 25-30 and 1:100 in women aged 35-40. In 10%-28% of cases, PPOI causes primary and in 4%-18% secondary amenorrhea. The process is a consequence of accelerated oocyte atresia, diminished number of germinated cells, and central nervous system aging. Specific genes are responsible for the control of oocyte number undergoing the ovulation process and the time to cessation of the reproductive function. A positive family history of PPOI is found in 15% of women with PPOI, indicating the existing genetic etiology. Primary POI comprises genetic aberrations linked to chromosome X (monosomy, trisomy, translocation, deletion) or to autosomal chromosome. Secondary POI implies surgical removal of ovaries, chemotherapy and radiotherapy, and infections. Diagnostic criteria include follicle stimulating hormone level >40 IU/L and estradiol level <50 pmol/L.
    Vir: Acta clinica Croatica. - ISSN 0353-9466 (Vol. 55, no. 4, 2016, str. 629-635)
    Vrsta gradiva - članek, sestavni del
    Leto - 2016
    Jezik - angleški
    COBISS.SI-ID - 91569409

    Povezava(-e):

    http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=262436
    Digitalna knjižnica Univerze v Mariboru – DKUM
    DOI

vir: Acta clinica Croatica. - ISSN 0353-9466 (Vol. 55, no. 4, 2016, str. 629-635)

loading ...
loading ...
loading ...

Vnos na polico