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  • Mathematical modeling of the myosin light chain kinase activation
    Fajmut, Aleš ; Jagodič, Marko, 1981- ; Brumen, Milan, 1951-
    The mathematical model presented here describes the interactions among ▫$Ca^{2+}$▫, calmodulin (CaM), and myosin light chain kinase (MLCK) and consists of a kinetic scheme taking into account 7 ... reactions instead of 12 as proposed previously. We derive a system of 5 nonlinear ordinary differential equations. Solving it yields the prediction of active MLCK as a function of ▫$[Ca^{2+}]$▫ whereby the active MLCK is defined to be proportional to the ▫$Ca_CaM \bullet MLCK$▫ complex concentration. The model predictions are compared with other theoretical and experimental predictions of active MLCK as well as with the results of our previously proposed complex model.
    Vir: Journal of chemical information and modeling. - ISSN 1549-9596 ([Vol.] 45, 2005, str. 1605-1609)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 14354184

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