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  • Beljakovine, ki uravnavajo dejavnost komplementnega sistema in rast tumorjev = Complement regulatory proteins in tumor growth
    Tedesco, Francesco ; Macor, Paolo
    Interest in the protective role of complement against tumor growth has been raised by the recent introduction of monoclonal antibodies to tumor antigens in the treatment of some tumors. The ability ... of the antibodies to activate thecomplement system depends on several factors, including the epitope densityof the target antigen, the antibody class and the efficiency of the complement system. Several inhibitors tightly regulate the latter by acting inthe fluid phase on the cell membrane. Tumor cells have developed efficient mechanisms to evade complement attack, one of which consists of the overexpression of complement regulators. These proteins have been documented in tumor tissue and on cell lines, and in several instances they have been found to be inversely correlated with the amount of complement components deposited on tumor tissue and with the susceptibility of tumor cells to complement-dependent cell cytoxicity. The availability of human phage display library has enabled our group to isolate scFvs that recognize CD59 and CD46 and neutralize the functional activity of these complement regulators. The results of in vitro studies have revealed that the complement dependent cytotoxicity of B lymphoma cell lines can be enhanced by the addition of thesescFvs.
    Vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 43, suppl. 5, 2004, str. 121-124)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2004
    Jezik - angleški
    COBISS.SI-ID - 18598105

vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 43, suppl. 5, 2004, str. 121-124)

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