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  • Učinkovitost kombiniranega zdravljenja hiperholesterolemije s statini in ezetimibom - prikaz rezultatov raziskave SI-SPECT = Effectiveness of combined statin plus ezetimibe treatment of hypercholesterolemia - presentation of SI-SPECT programme results
    Fras, Zlatko
    Background. Despite the established effectiveness of statins, still many patients with dyslipidemia do not achieve recommended LDL cholesterol (LDL-C) goals. Contributing factors may be inadequate ... dosing, as well as increased potential for intolerance and adverse effects with combinations of available agents. Ezetimibe, the first member of a new class of selective cholesterol absorption inhibitors, is an effective and safe agent for lowering LDL-C and non HDL-C and it was previously shown that ezetimibe and statin combination therapy increased the percentage of patients who achieved their LDL-C treatment goal. Objectives. Treatment monitoring programme SI-SPECT (Slovenia (SI) Statin Plus Ezetimibe in Cholesterol Treatment) was setup to evaluate thetotal as well as LDL blood cholesterol lowering in patients treated with ezetimibe co-administered to on-going statin therapy in daily clinical practice (S+E). It was also investigated whether and to what extent the targetlevels set by the participating doctors are achieved by the co-administration therapy. Subject and methods. 1,067 pts (52% males, age 60,2years, 42,9% with CHD, 32,0% diabetes mellitus, 96,5% with hypercholesterolemia, and 69,6% hypertension) were enrolled to initiate ezetimibe 10 mg plus continued their already prescribed statin. Baselin lipid levels were compared to those obtained at the 2nd visit (12 to 16 weeks after the initiation). Results. Significant positive changes were achieved in various lipid parameters due to "add-on" ezetimibe+statin combination therapy.Total and LDL cholesterol as well as triglycerides (TG) decreased significantly (by 25,3%, 31,4%, and 28,9% respectively, p=0.000 for all comparisons), while HDL increased by 1,0% (NS) during the study period. (Abstract truncated at 2000 characters(
    Vir: Slovenska kardiologija : znanstveno strokovna revija za področje srčno-žilne medicine. - ISSN 1581-8543 (Letn. 3, št. 1, 2006, str. 14-21)
    Vrsta gradiva - članek, sestavni del
    Leto - 2006
    Jezik - slovenski
    COBISS.SI-ID - 21311193

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