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  • Vpliv mikrocistinov na regeneracijo jetrnih celic podgane : magistrsko delo
    Milutinović Živin, Aleksandra, 1969-
    Microcystins are a family of over SO structurally similar cyanobacterial hepatotoxins. The toxins have been found in eutrophycated waters in all parts of Slovenia. The only exception are the mountain ... lakes at high altitude. In order to assess the presence of toxic cyanobacterial bloom in densely populated area a sample was taken from ĆKoseŠki bajerĆ in Ljubljana, and it was found that it contains microcystin YR, LR an RR. A cumulative toxicity of the toxins was assumed, and LD 50 was determinedČ for MC-YR 20.45 microgžkg for YR 55.76 microgžkg and for RR 11.15 microgžkg. The enlargement of liver mass was dose-dependent. Although acute toxic effects are highly lethal the chronic effects may be more important for human population due to the possiblechronic exposure to sublethal doses of the toxins. Chronic effects have been studied on male rats (Fischer) after partial hepatectomy. Liver regeneration as well as possible degenerative effects were studied using MRI, patohystological techniques and macroscopic pathoanatomical observation. Afterthe surgical liver resection one group of animals received a mixture of methanol and ethanol, and the other group received microcystin YR (5 microgžkg) dissolved in the mixture of methanol and ethanol. Weight gain and food consumption were also measured throughout the experiment. The weight gainwas reduced in the group treated with MC-YR, and liver regeneration was suppressed three fold as compared to the control group. Macroscopic pathoanatomical inspection also revealed impaired liver regeneration in the group of experimental animals treated with MC-YR. Pathohystological examination confirmed these findings. Additionally, degenerative changes of the liver left after the surgical resection were observed both in the control group treated with alcohol and in the group treated with microcystins, but thedegeneration was more pronounced in the latter. (Abstract truncated at 2000characters).
    Vrsta gradiva - magistrsko delo
    Založništvo in izdelava - Ljubljana : [A. Milutinović], 2000
    Jezik - slovenski
    COBISS.SI-ID - 2176532

Knjižnica Signatura – lokacija, inventarna št. ... Status izvoda
MF, Centralna medicinska knjižnica, Ljubljana magistrske naloge
MILUTINOVIĆ A. Vpliv
IN: 020000821 		prosto - na dom, čas izposoje: 1 mes.
Nacionalni inštitut za biologijo in BF, Oddelek za biologijo, Ljubljana BF oddelek za biologijo
mg 615 MILUTINOVIĆ A. Vpliv
IN: 0034989 		prosto - za čitalnico
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