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  • Vpliv elektroporacije na učinek kombiniranega zdravljenja eksperimentalnih tumorjev s cisplatinom in obsevanjem : [magistrsko delo]
    Kranjc Brezar, Simona
    One of the defects that obstructs a more effective reaction of chemotherapeutic drugs on tumor cells is their poor and slow transfer through the cell membrane of tumor cells in vitro and in vivo. The ... tumor cells were electroporated reversely with the application of short highvoltage electric pulses (electroporation). The molecules of the chernotherapeutic drugs can enter the tumor cells through the pores in the membrane. Cisplatin is the mostoften used chemotherapeutic drug with cytotoxic and radiosensitising effect. Cisplatin changes the structure of DNA molecule in the cell by crossbinding to the DNA molecule and chromosomal proteins. Its use in clinicalpractice is limited due to its slow efflux through the cell membrane, the resistance of certain tumor cells to cisplatin and its binding to specificproteins in the tissue (the liver, kidney, brain). Electroporation increases the tumor cell uptake of cisplatin as well as its effect on the tumor cells. In this Masterćs Thesis, we examined whether the electroporation with cisplatin increases the effect of irradiation on the two mouse tumor models, i. e. LPB fibrosarcoma tumor cells and Ehrlich ascites carcinoma (EAT)in vivo. (Abstract truncated at 2000 characters).
    Vrsta gradiva - magistrsko delo
    Založništvo in izdelava - Ljubljana : [S. Kranjc], 2001
    Jezik - slovenski
    COBISS.SI-ID - 2327316

Knjižnica Signatura – lokacija, inventarna št. ... Status izvoda
MF, Centralna medicinska knjižnica, Ljubljana magistrske naloge
KRANJC Simona Vpliv
IN: 020010901 		prosto - na dom, čas izposoje: 1 mes.
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