-
Association of cytokine gene polymorphisms with psoriasis in cases from the Nile delta of EgyptSettin, Ahmad ...Background: Psoriasis is a chronic inflammatory skin disease with an immunogenetic background. This study was planned to check for the association of polymorphisms related to cytokine genes TNF-alpha ... 308(G/A), IL-10.1082(G/A), IL-6-174(G/C), and IL-1Ra (VNTR) with psoriasis in cases fromEgypt. Methods: This study included 46 cases with psoriasis recruited fromthe Department of Dermatology, University Hospitals, Nile Delta region of Egypt. They included 14 males and 32 females with a mean age SD of 46.68 12.16 years and a range of 15 to 70 years. Their genotypes were compared to 98healthy controls of matched age and sex from the same locality. Genotyping was done through DNA amplification using PCR with sequence-specific primers for polymorphic alleles. Results: Compared to controls, cases showed a significantly higher frequency of certain genotypes including IL-6.174 CC (p <0.001, OR = 6.7), IL-10.1082 GG (p < 0.05, OR = 5.1), and TNF-alpha 308 GG (p< 0.05, OR = 3.7). Combined heterozygosity for IL-10 GA, IL-6 GC, and TNF GAshowed a significant low frequency among the cases studied. Conclusion: Genetic polymorphisms related to the IL6, IL10, and TNF-alpha genes showed a particular pattern of association with psoriasis that may have a potential impact on disease counseling and management.Vir: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Vol. 18, no. 3, 2009, str. 105-112)Vrsta gradiva - članek, sestavni delLeto - 2009Jezik - angleškiCOBISS.SI-ID - 26520281
Avtor
Settin, Ahmad |
Hassan, Hanaa |
El-Baz, Rizk |
Hassan, Tahia
Teme
Psoriasis |
Genetics |
Polymorphism (Genetics) |
Cytokines |
Polymerase Chain Reaction |
Alleles |
Tumor Necrosis Factor |
Interleukin-10 |
Interleukin-6 |
Interleukin-1 |
Egypt |
Polimerazna, verižna reakcija |
Polimorfizem (genetika) |
Citokini |
Psoriaza |
Aleli |
Tumor nekrotizirajoči faktor |
Interlevkin-6 |
Interlevkin-1 |
Egipt |
Interlevkin-10
vir: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Vol. 18, no. 3, 2009, str. 105-112)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Settin, Ahmad | |
Hassan, Hanaa | |
El-Baz, Rizk | |
Hassan, Tahia |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.