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Step-wise approach to developing a scale-independent design space for functional tablet coating processDebevec, Veronika ...The objective of this study is to present a practical example of a scale-independent design space development using a step-wise approach. A detailed description of the development process with a ... systematic outline of the main steps is provided. Design space is developed for film coating of tablets with moisture protective polyvinyl alcohol (PVA) based coating. The impact of scale-independent coating process parameters on the properties of film-coated tablets (FCT), i.e. water activity and film coating protection ability, and consequently on product long-term stability is explored. The main finding is that with model simplifications, a step-wise approach and rational development of scale-independent design space for the coating process, it is possible to efficiently predict, control, and optimize the long-term stability of a moisture sensitive product. However, the PVA moisture protective coating itself is recognized as having conflicting effects on product stability.Vir: Drug development and industrial pharmacy. - ISSN 0363-9045 (Vol. 46, iss. 4, 2020, str. 566-575)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2020Jezik - angleškiCOBISS.SI-ID - 28473859
Povezava(-e):
https://www.tandfonline.com/doi/full/10.1080/03639045.2020.1742140Dostop do polnega teksta z geslom
DOI
Avtor
Debevec, Veronika |
Stanić Ljubin, T. |
Jeraj, Žiga |
Rozman Peterka, Tanja |
Bratuž, Borut |
Gašperlin, Dušan |
Srčič, Stanko |
Horvat, Matej, 1979-
Teme
Farmacevtska tehnologija |
Zdravila |
Quality by design (QbD) |
coating process |
design of experiments (DoE) |
design space |
empirical modeling |
hybrid modeling |
mechanistic modeling |
scale-independent parameters
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vir: Drug development and industrial pharmacy. - ISSN 0363-9045 (Vol. 46, iss. 4, 2020, str. 566-575)
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Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Debevec, Veronika | 35859 |
Stanić Ljubin, T. | ![]() |
Jeraj, Žiga | ![]() |
Rozman Peterka, Tanja | 24895 |
Bratuž, Borut | ![]() |
Gašperlin, Dušan | ![]() |
Srčič, Stanko | 09031 |
Horvat, Matej, 1979- | 22306 |
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