NUK - logo
(UL)
  • Step-wise approach to developing a scale-independent design space for functional tablet coating process
    Debevec, Veronika ...
    The objective of this study is to present a practical example of a scale-independent design space development using a step-wise approach. A detailed description of the development process with a ... systematic outline of the main steps is provided. Design space is developed for film coating of tablets with moisture protective polyvinyl alcohol (PVA) based coating. The impact of scale-independent coating process parameters on the properties of film-coated tablets (FCT), i.e. water activity and film coating protection ability, and consequently on product long-term stability is explored. The main finding is that with model simplifications, a step-wise approach and rational development of scale-independent design space for the coating process, it is possible to efficiently predict, control, and optimize the long-term stability of a moisture sensitive product. However, the PVA moisture protective coating itself is recognized as having conflicting effects on product stability.
    Vir: Drug development and industrial pharmacy. - ISSN 0363-9045 (Vol. 46, iss. 4, 2020, str. 566-575)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2020
    Jezik - angleški
    COBISS.SI-ID - 28473859

    Povezava(-e):

    https://www.tandfonline.com/doi/full/10.1080/03639045.2020.1742140

    Dostop do polnega teksta z geslom


    DOI

vir: Drug development and industrial pharmacy. - ISSN 0363-9045 (Vol. 46, iss. 4, 2020, str. 566-575)

loading ...
loading ...
loading ...

Vnos na polico