(UL)
-
Targeting tumor cells and stimulus-induced delivery of drug with mesoporous silica nanoparticles-based system [Elektronski vir]Nadrah, Peter ...Drug delivery systems based on mesoporous silica nanoparticles (MSNs) have received much attention recently. Biocompatibility, chemical stability, ease of functionalization and porosity have ... attributed to the popularity of MSNs. Functional groups on surface allow stimulus-induced release of the cargo with zero premature release. In this regard glutathione is an important stimulus since the difference between intracellular and extracellular concentration allow drug release only inside cells. Moreover, the ability to deliver a significant amount of drug in a specific environment is an important prerequisite to prevent severe side effects. Selective targeting of delivery systems towards cancer cells is possible via their overexpressed folate receptors. Herein we present a novel type of functionalized MSNs able to incorporate targeting ability towards specific cells and release the drug upon endogenous stimulus with activation of the nanovalve. We synthesized fluorescent dye loaded MSNs (100 nm). Next, dendrimers were attached to the mesopore openings to act as a stopper and prevent leakage of the dye. The outer surface of particles was decorated with folic acid moieties providing affinity to folate receptors. Upon the addition of reducing agent the dendrimers detached and released the dye. In conclusion we have synthesized target selective MSNs with the ability to safely transport drug avoiding its premature release. Drug release is enabled only upon biological stimulus.Vrsta gradiva - prispevek na konferenciLeto - 2012Jezik - angleškiCOBISS.SI-ID - 36964101
Avtor
Nadrah, Peter |
Porta, Fabiola |
Planinšek, Odon |
Kros, Alexander |
Gaberšček, Miran
Teme
biokemija |
materiali |
struktura snovi
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Nadrah, Peter | 32104 |
Porta, Fabiola | ![]() |
Planinšek, Odon | 14935 |
Kros, Alexander | ![]() |
Gaberšček, Miran | 00582 |
Vir: Osebne bibliografije
in: SICRIS
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Naslov za dostavo:
Med podatki člana manjka naslov.
Storitev za pridobivanje naslova trenutno ni dostopna, prosimo, poskusite še enkrat.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in naslov za dostavo ter dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrani naslov za dostavo in dokončali postopek rezervacije.
Obvestilo
Trenutno je storitev za avtomatsko prijavo in rezervacijo nedostopna. Gradivo lahko rezervirate sami na portalu Biblos ali ponovno poskusite tukaj kasneje.
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Gradivo iz matične enote je brezplačno. Če je gradivo na mesto prevzema dostavljeno iz drugih enot, lahko knjižnica to storitev zaračuna.
Mesto prevzema | Status gradiva | Rezervacija |
---|
Rezervacija v teku
Prosimo, počakajte trenutek.
Rezervacija je uspela.
Rezervacija ni uspela.
Rezervacija...
Članska izkaznica:
Mesto prevzema: