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Urotelijske celice sečnega mehurja miši med eksperimentalno ishemijo : magistrsko deloKorošec, Peter, 1970-An ischemic in vivo model of urinary bladder was developed to study early molecular and ultrastructural changes of the mice urothelium. THe urothelium rnse to short-term experimental ischemia (30 to ... 120 minutes) was investigated by light, fluorescence and electron microscopy using immunocytochemistral and histochemistral methods as well as by flouremetric measurement of the (Ca2+)i.It was established that ischemic alterations are focally distributed and expressed by desquamation of all strata of the urothelium. Urothelium damages occur as funnels formed wounds extending to the basal cells. The damages are proportional to the duration of ischemia, contraction effect in vivo and in vivo induced reperfusion. Ischemia causes a disruption of the celljunctions and consequently the blood urine barrier. These changes are related to the increased (Ca2+)i and alternation of actin cytoskeleton. Exposal of desquamated live cells to the hypertonic and toxic urine gradually leads to irreversible changes.Vrsta gradiva - magistrsko deloZaložništvo in izdelava - Ljubljana : [P. Korošec], 1998Jezik - slovenskiCOBISS.SI-ID - 9348057
Avtor
Korošec, Peter, 1970-
Drugi avtorji
Jezernik, Kristijan
Teme
Bladder |
Blood supply |
Urothelium |
Ultrastructure |
Ischemia |
Mice |
Vasoconstriction |
Microscopy, electron |
Cytochrome-c oxidase |
Lanthanum |
Immunohistochemistry |
Cell membrane |
Cell membrane permeability |
Cytoskeleton |
Calcium |
Indigo carmine |
Trypan blue |
Succinate dehydrogenase |
Fluorometry |
Microscopy, fluorescence |
Reperfusion
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Knjižnica | Signatura – lokacija, inventarna št. ... | Status izvoda |
---|---|---|
Nacionalni inštitut za biologijo in BF, Oddelek za biologijo, Ljubljana | BF oddelek za biologijo mg 61 KOROŠEC P. Urotelijske IN: 0032115 |
prosto - za čitalnico |
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Korošec, Peter, 1970- | 22807 |
Jezernik, Kristijan | 05277 |
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