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Mbatchi, Litaty Céphanoée; Schmitt, Antonin; Thomas, Fabienne; Cazaubon, Yoann; Robert, Jacques; Lumbroso, Serge; Brouillet, Jean-Paul; Pourquier, Philippe; Chatelut, Etienne; Boyer, Jean-Christophe; Evrard, Alexandre
Pharmacogenomics, 08/2015, Letnik: 16, Številka: 13Journal Article
The goal of our study was to assess the impact of patients' genetic background on their sensitivity to carboplatin/paclitaxel hematotoxicity. Parameters describing sensitivity to neutropenia and to thrombocytopenia of 201 patients were extracted from a previous pharmacokinetic/pharmacodynamics analysis, in order to assess their association with 52 candidates SNPs in 18 genes. Carriers of a T allele of SLCO1B3-rs4149117 were 19% less sensitive to thrombocytopenia than the homozygotes for the G allele (p = 0.00279). Carriers of two copies of the ATG haplotypes of NR1I2-rs1523130, rs3814055 and rs1523127 were 19% less sensitive to thrombocytopenia than those harboring other haplotypes (p = 0.025). Our results revealed the importance of SLCO1B3 and NR1I2 in the sensitivity to carboplatin/paclitaxel thrombocytopenia.
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in: SICRIS
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