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Hinchliffe, Alice; Kogevinas, Manolis; Pérez-Gómez, Beatriz; Ardanaz, Eva; Amiano, Pilar; Marcos-Delgado, Alba; Castaño-Vinyals, Gemma; Llorca, Javier; Moreno, Víctor; Alguacil, Juan; Fernandez-Tardón, Guillermo; Salas, Dolores; Marcos-Gragera, Rafael; Aragonés, Nuria; Guevara, Marcela; Gil, Leire; Martin, Vicente; Benavente, Yolanda; Gomez-Acebo, Ines; Santibáñez, Miguel; Ángel Alba, Miguel; García, Ana M; Pollán, Marina; Turner, Michelle C
Cancer epidemiology, biomarkers & prevention, 02/2021, Letnik: 30, Številka: 2Journal Article
Mechanisms linking occupational heat exposure with chronic diseases have been proposed. However, evidence on occupational heat exposure and cancer risk is limited. We evaluated occupational heat exposure and female breast cancer risk in a large Spanish case-control study. We enrolled 1,738 breast cancer cases and 1,910 frequency-matched population controls. A Spanish job-exposure matrix, MatEmEsp, was used to assign estimates of the proportion of workers exposed ( ≥ 25% for at least 1 year) and work time with heat stress (wet bulb globe temperature ISO 7243) for each occupation. We used three exposure indices: ever versus never exposed, lifetime cumulative exposure, and duration of exposure (years). We estimated ORs and 95% confidence intervals (CI), applying a lag period of 5 years and adjusting for potential confounders. Ever occupational heat exposure was associated with a moderate but statistically significant higher risk of breast cancer (OR 1.22; 95% CI, 1.01-1.46), with significant trends across categories of lifetime cumulative exposure and duration ( = 0.01 and 0.03, respectively). Stronger associations were found for hormone receptor-positive disease (OR ever exposure = 1.38; 95% CI, 1.12-1.67). We found no confounding effects from multiple other common occupational exposures; however, results attenuated with adjustment for occupational detergent exposure. This study provides some evidence of an association between occupational heat exposure and female breast cancer risk. Our results contribute substantially to the scientific literature. Further investigations are needed considering multiple occupational exposures.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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