E-viri
Recenzirano
-
Cordeiro, Yraima; Silva, Jerson L
Protein and peptide letters 12, Številka: 3Journal Article
The main hypothesis for prion diseases proposes that the cellular protein (PrP(c)) can be altered into a misfolded, beta-sheet-rich isoform (PrP(Sc)). We describe here that host nucleic acid may catalyze the conversion between PrP(c) and PrP(Sc) isoforms, by reducing the protein mobility and by making the protein-protein interactions more likely. We summarize the findings, focusing in the biological relevance of the catalytic action of nucleic acid.
