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Ghilardi, Guido; Fraietta, Joseph A; Gerson, James N; Van Deerlin, Vivianna M; Morrissette, Jennifer J D; Caponetti, Gabriel C; Paruzzo, Luca; Harris, Jaryse C; Chong, Elise A; Susanibar Adaniya, Sandra P; Svoboda, Jakub; Nasta, Sunita D; Ugwuanyi, Ositadimma H; Landsburg, Daniel J; Fardella, Eugenio; Waxman, Adam J; Chong, Emeline R; Patel, Vrutti; Pajarillo, Raymone; Kulikovskaya, Irina; Lieberman, David B; Cohen, Adam D; Levine, Bruce L; Stadtmauer, Edward A; Frey, Noelle V; Vogl, Dan T; Hexner, Elizabeth O; Barta, Stefan K; Porter, David L; Garfall, Alfred L; Schuster, Stephen J; June, Carl H; Ruella, Marco
Nature medicine, 04/2024, Letnik: 30, Številka: 4Journal Article
We report a T cell lymphoma (TCL) occurring 3 months after anti-CD19 chimeric antigen receptor (CAR) T cell immunotherapy for non-Hodgkin B cell lymphoma. The TCL was diagnosed from a thoracic lymph node upon surgery for lung cancer. The TCL exhibited CD8 cytotoxic phenotype and a JAK3 variant, while the CAR transgene was very low. The T cell clone was identified at low levels in the blood before CAR T infusion and in lung cancer. To assess the overall risk of secondary primary malignancy after commercial CAR T (CD19, BCMA), we analyzed 449 patients treated at the University of Pennsylvania. At a median follow-up of 10.3 months, 16 patients (3.6%) had a secondary primary malignancy. The median onset time was 26.4 and 9.7 months for solid and hematological malignancies, respectively. The projected 5-year cumulative incidence is 15.2% for solid and 2.3% for hematological malignancies. Overall, one case of TCL was observed, suggesting a low risk of TCL after CAR T.
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in: SICRIS
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