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  • Sandhu, Punam; Andrews, Paul A; Baker, Maribeth P; Koeplinger, Kenneth A; Soli, Eric D; Miller, Thomas; Baillie, Thomas A

    Drug metabolism letters 1, Številka: 2
    Journal Article

    The disposition of vorinostat, an anticancer agent, was investigated in rats and dogs. Vorinostat possessed high serum clearance, a short elimination half-life and low oral bioavailability in both species. The renal route played an important role in the elimination of drug-related material and vorinostat was eliminated primarily by metabolic biotransformation.