E-viri
Recenzirano
-
Liu, Bingchun; Wei, Chunyan
Journal of environmental pathology, toxicology and oncology, 2021, Letnik: 40, Številka: 1Journal Article
Lung cancer is the world-leading causative factor of disease-related death. CD4+CD25+ regulatory T cells (CD4+CD25+ Treg), which are involved in immune escape of tumor cells, are highly related to tumor development and metastasis. Hypoxia induces the overexpression of chemokine (C-C motif) ligand 28 (CCL28), thus enhancing the angiogenesis and metastasis of lung adenocarcinoma. Our study revealed that most clinical lung adenocarcinoma samples showed positive expressions of HIF-lα, VEGF, FoxP3, and CCL28. More CD4+CD25+ Treg cells were detected in the cancerous samples. In addition, hypoxia increased the expression of HIF-1α and upregulated CCL28 to recruit CD4+CD25+ Treg cells; knockdown of HIF-1α could reverse this process. Treg cells also promoted invasion, migration, and angiogenesis in two human lung adenocarcinoma cell lines A549 and H1975. Our study suggested a novel potential molecular mechanism involved in the progression of lung adenocarcinoma could be a potential therapeutic target for the treatment of lung cancer.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.