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Sehgal, Lalit; Mukhopadhyay, Amitabha; Rajan, Anandi; Khapare, Nileema; Sawant, Mugdha; Vishal, Sonali S; Bhatt, Khyati; Ambatipudi, Srikant; Antao, Noelle; Alam, Hunain; Gurjar, Mansa; Basu, Srikanta; Mathur, Rohit; Borde, Lalit; Hosing, Amol S; Vaidya, Milind M; Thorat, Rahul; Samaniego, Felipe; Kolthur-Seetharam, Ullas; Dalal, Sorab N
Journal of cell science, 2014-May-15, Letnik: 127, Številka: Pt 10Journal Article
The regulation of cell-cell adhesion is important for the processes of tissue formation and morphogenesis. Here, we report that loss of 14-3-3γ leads to a decrease in cell-cell adhesion and a defect in the transport of plakoglobin and other desmosomal proteins to the cell border in HCT116 cells and cells of the mouse testis. 14-3-3γ binds to plakoglobin in a PKCμ-dependent fashion, resulting in microtubule-dependent transport of plakoglobin to cell borders. Transport of plakoglobin to the border is dependent on the KIF5B-KLC1 complex. Knockdown of KIF5B in HCT116 cells, or in the mouse testis, results in a phenotype similar to that observed upon 14-3-3γ knockdown. Our results suggest that loss of 14-3-3γ leads to decreased desmosome formation and a decrease in cell-cell adhesion in vitro, and in the mouse testis in vivo, leading to defects in testis organization and spermatogenesis.
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