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Hilton, Kira L F; Karamalegkos, Antonis A; Allen, Nyasha; Gwynne, Lauren; Streather, Bree; White, Lisa J; Baker, Karen B; Henry, Samantha A; Williams, George T; Shepherd, Helena J; Shepherd, Mark; Hind, Charlotte K; Sutton, Mark J; Jenkins, Toby A; Mulvihill, Daniel P; Tullet, Jennifer M A; Ezcurra, Marina; Hiscock, Jennifer R
Journal of materials chemistry. B, Materials for biology and medicine, 05/2023, Letnik: 11, Številka: 17Journal Article
Antimicrobial resistance is one of the greatest threats to human health. Gram-positive methicillin resistant (MRSA), in both its planktonic and biofilm form, is of particular concern. Herein we identify the hydrogelation properties for a series of intrinsically fluorescent, structurally related supramolecular self-associating amphiphiles and determine their efficacy against both planktonic and biofilm forms of MRSA. To further explore the potential translation of this hydrogel technology for real-world applications, the toxicity of the amphiphiles was determined against the eukaryotic multicellular model organism, . Due to the intrinsic fluorescent nature of these supramolecular amphiphiles, material characterisation of their molecular self-associating properties included; comparative optical density plate reader assays, rheometry and widefield fluorescence microscopy. This enabled determination of amphiphile structure and hydrogel sol dependence on resultant fibre formation.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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