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Woodruff, Matthew C; Ramonell, Richard P; Nguyen, Doan C; Cashman, Kevin S; Saini, Ankur Singh; Haddad, Natalie S; Ley, Ariel M; Kyu, Shuya; Howell, J Christina; Ozturk, Tugba; Lee, Saeyun; Suryadevara, Naveenchandra; Case, James Brett; Bugrovsky, Regina; Chen, Weirong; Estrada, Jacob; Morrison-Porter, Andrea; Derrico, Andrew; Anam, Fabliha A; Sharma, Monika; Wu, Henry M; Le, Sang N; Jenks, Scott A; Tipton, Christopher M; Staitieh, Bashar; Daiss, John L; Ghosn, Eliver; Diamond, Michael S; Carnahan, Robert H; Crowe, Jr, James E; Hu, William T; Lee, F Eun-Hyung; Sanz, Ignacio
Nature immunology, 12/2020, Letnik: 21, Številka: 12Journal Article
A wide spectrum of clinical manifestations has become a hallmark of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic, although the immunological underpinnings of diverse disease outcomes remain to be defined. We performed detailed characterization of B cell responses through high-dimensional flow cytometry to reveal substantial heterogeneity in both effector and immature populations. More notably, critically ill patients displayed hallmarks of extrafollicular B cell activation and shared B cell repertoire features previously described in autoimmune settings. Extrafollicular activation correlated strongly with large antibody-secreting cell expansion and early production of high concentrations of SARS-CoV-2-specific neutralizing antibodies. Yet, these patients had severe disease with elevated inflammatory biomarkers, multiorgan failure and death. Overall, these findings strongly suggest a pathogenic role for immune activation in subsets of patients with COVID-19. Our study provides further evidence that targeted immunomodulatory therapy may be beneficial in specific patient subpopulations and can be informed by careful immune profiling.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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