E-viri
Recenzirano
Odprti dostop
-
Klein, Marieke; Singgih, Euginia L; van Rens, Anne; Demontis, Ditte; Børglum, Anders D; Mota, Nina Roth; Castells-Nobau, Anna; Kiemeney, Lambertus A; Brunner, Han G; Arias-Vasquez, Alejandro; Schenck, Annette; van der Voet, Monique; Franke, Barbara
The American journal of psychiatry, 06/2020, Letnik: 177, Številka: 6Journal Article
Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable neuropsychiatric disorder. ADHD often co-occurs with intellectual disability, and shared overlapping genetics have been suggested. The aim of this study was to identify novel ADHD genes by investigating whether genes carrying rare mutations linked to intellectual disability contribute to ADHD risk through common genetic variants. Validation and characterization of candidates were performed using . Common genetic variants in a diagnostic gene panel of 396 autosomal intellectual disability genes were tested for association with ADHD risk through gene set and gene-wide analyses, using ADHD meta-analytic data from the Psychiatric Genomics Consortium for discovery (N=19,210) and ADHD data from the Lundbeck Foundation Initiative for Integrative Psychiatric Research for replication (N=37,076). The significant genes were functionally validated and characterized in by assessing locomotor activity and sleep upon knockdown of those genes in brain circuits. The intellectual disability gene set was significantly associated with ADHD risk in the discovery and replication data sets. The three genes most consistently associated were , , and . Performing functional characterization of the two evolutionarily conserved genes in , the authors found that their knockdown in dopaminergic ( ) and circadian neurons ( ) resulted in increased locomotor activity and reduced sleep, concordant with the human phenotype. This study reveals that a large set of intellectual disability-related genes contribute to ADHD risk through effects of common alleles. Utilizing this continuity, the authors identified , , and as novel ADHD candidate genes. Characterization in suggests that and contribute to ADHD-related behavior through distinct neural substrates.
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.