E-viri
Recenzirano
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Crowe, J. Scott; Gewert, Dirk R.; Barber, Karen A.; Lewis, Alan P.; Sims, Martin J.; Davies, Sara L.; Salom, Caroline L.; Wood, John; Thomas, Howard C.; Thursz, Mark; Lok, Anna S.
The Journal of infectious diseases, 04/1994, Letnik: 169, Številka: 4Journal Article
Sixteen Chinese chronic hepatitis B virus (HBV)-infected patients were treated with recombinant interferon-α2a (rIFN-α2a). Of these, 8 made a response to IFN, with titers of neutralizing antibody of 141-4525 as determined by an antiviral neutralization bioassay. To determine whether the immunogenicity of the IFN was directly linked to the patients' genotype, their genomic DNA was analyzed for the presence of the human IFN-α2a gene. None of the patients possessed the gene for IFN-α2a, but only 50% developed neutralizing antibodies. The hypothesis, therefore, of a direct link between antibody formation and genotype cannot be sustained. Alternative explanations of the immunogenicity of IFN-α2a must be sought.
