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Smith, Toby O; Mansfield, Michael; Hawker, Gillian A; Hunter, David J; March, Lyn M; Boers, Maarten; Shea, Beverley J; Christensen, Robin; Guillemin, Francis; Terwee, Caroline B; Williamson, Paula R; Roos, Ewa M; Loeser, Richard F; Schnitzer, Thomas J; Kloppenburg, Margreet; Neogi, Tuhina; Ladel, Christoph H; Kalsi, Gurdyal; Kaiser, Ulrike; Buttel, Thomas W; Ashford, Anne E; Mobasheri, Ali; Arden, Nigel K; Tennant, Alan; Hochberg, Marc C; de Wit, Maarten; Tugwell, Peter; Conaghan, Philip G
Journal of rheumatology, 08/2019, Letnik: 46, Številka: 8Journal Article
To assess the uptake of the OMERACT-OARSI (Outcome Measures in Rheumatology- Osteoarthritis Research Society International) core outcome set (COS) domains in hip and/or knee osteoarthritis (OA) trials. There were 382 trials of hip and/or knee OA identified from the ClinicalTrial.gov registry from 1997 to 2017. Frequency of COS adoption was assessed by year and per 5-yearly phases. COS adoption decreased from 61% between 1997 and 2001 to 38% between 2012 and 2016. Pain (95%) and physical function (86%) were most consistently adopted. Patient's global assessment (48%) was the principal missing domain. Limited adoption of the COS domains indicates that further consideration to improve uptake is required.
