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Liu, Meng; Zhang, Chao; Gong, Ximing; Zhang, Tian; Lian, Michelle Mulan; Chew, Elaine Guo Yan; Cardilla, Angelysia; Suzuki, Keiichiro; Wang, Huamin; Yuan, Yuan; Li, Yan; Naik, Mihir Yogesh; Wang, Yixuan; Zhou, Bingrui; Soon, Wei Ze; Aizawa, Emi; Li, Pin; Low, Jian Hui; Tandiono, Moses; Montagud, Enrique; Moya-Rull, Daniel; Rodriguez Esteban, Concepcion; Luque, Yosu; Fang, Mingliang; Khor, Chiea Chuen; Montserrat, Nuria; Campistol, Josep M; Izpisua Belmonte, Juan Carlos; Foo, Jia Nee; Xia, Yun
Cell stem cell, 01/2024, Letnik: 31, Številka: 1Journal Article
Human pluripotent stem cell-derived kidney organoids offer unprecedented opportunities for studying polycystic kidney disease (PKD), which still has no effective cure. Here, we developed both in vitro and in vivo organoid models of PKD that manifested tubular injury and aberrant upregulation of renin-angiotensin aldosterone system. Single-cell analysis revealed that a myriad of metabolic changes occurred during cystogenesis, including defective autophagy. Experimental activation of autophagy via ATG5 overexpression or primary cilia ablation significantly inhibited cystogenesis in PKD kidney organoids. Employing the organoid xenograft model of PKD, which spontaneously developed tubular cysts, we demonstrate that minoxidil, a potent autophagy activator and an FDA-approved drug, effectively attenuated cyst formation in vivo. This in vivo organoid model of PKD will enhance our capability to discover novel disease mechanisms and validate candidate drugs for clinical translation.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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