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Ortiz, Alexandra M; Flynn, Jacob K; DiNapoli, Sarah R; Vujkovic-Cvijin, Ivan; Starke, Carly E; Lai, Stephen H; Long, MacKenzie E; Sortino, Ornella; Vinton, Carol L; Mudd, Joseph C; Johnston, Leslie; Busman-Sahay, Kathleen; Belkaid, Yasmine; Estes, Jacob D; Brenchley, Jason M
Nature medicine, 09/2018, Letnik: 24, Številka: 9Journal Article
Intestinal microbial dysbiosis has been described in individuals with an HIV-1 infection and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques (Macaca mulatta) with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis similar to that observed in individuals with HIV is not sufficient to accelerate untreated lentiviral disease progression.
