A 63-year-old man was under observation after the resection of a stomach cancer. Abdominal computed tomography showed a low-density region, 8 mm in diameter, at segment 7 of the liver. Qualitative diagnosis was difficult, and the patient's clinical course was monitored. Six months later, the size of the low-density region increased to 25 mm. Malignant tumor was suspected, and partial resection of the liver (S7) was performed. Hepatic angiosarcoma was diagnosed on the basis of postoperative pathological examination. Because the surgical margin of the tumor was positive, right lobectomy of the liver was performed after 3 weeks. Two months later, recurrence was detected in the remnant liver ; diffuse small metastatic lesions appeared 5 months after the operation. Continuous arterial infusion of recombinant interleukin-2 was administered, and a partial response was obtained temporarily. However, the tumor recurred immediately, and the best supportive care was given. Although the tumor gradually increased in size, the patient's general condition was good for a long period. Around 1 year 9 months after the operation, the tumor began to grow rapidly, and liver dysfunction occurred. Two years 8 months after the onset, the patient died of hepatic failure.